Portal:IEM
From WikiPathways
This portal is set up to give an overview of all Inborn Errors of Metabolism (IEM) pathways.
IMPORTANT: the current list of pathways is based on the currently published (2014) 4th edition of the book (ISBN 3642403360 (978-3642403361)). There is a new edition(5) upcoming and the pathways in the new edition are being digitized in a collaboration with the chapter authors, but these have no been made public yet, and therefore do not show up here yet.
Covered Pathways
| Chapter ed. 5 | Title | Links WP | Chapter ed. 4 | Status |
|---|---|---|---|---|
| 13 | Disorders of pyrimidine and purine metabolism | WP4225 and WP4224 | 41 | Approved |
| 16 | Disorders of glutathione metabolism | WP4518 | 42 | Approved |
| 19 | Disorders of monoamine metabolism | WP4220 | 31 | Approved |
| 20 | Disorders of phenylalanine and tetrahydrobiopterin metabolism | WP4156 | 1 | Approved |
| 21 | Disorders of tyrosine metabolism | WP4506 | 2 | Approved |
| 22 | Disorders of sulfur amino acid and sulfide metabolism | WP4292 | 3 | Approved |
| 23 | Disorders of branched-chain amino acid metabolism | WP4686 | 7 | In Progress |
| 26 | Disorders of glycine metabolism | WP4688 | 5 | In Progress |
| 28 | Disorders of cobalamin metabolism | WP4271 | 13 | Approved |
| 29 | Disorders of folate metabolism | WP4259 and WP4288 | 10 | Approved |
| 31 | Disorders of thiamine metabolism | WP4297 | 15 | Approved |
| 34 | Vitamin B6 -Dependent and Responsive Disorders | WP4228 | 11 | Approved |
| 35 | Disorders of molybdenum metabolism | WP4507 and WP4504 | 12 | Approved |
| 42 | Disorders of pyruvate and Krebs cycle metabolism | WP4236 | 20 | Approved |
| 53 | Disorders of lipoprotein metabolism | WP4522 | 43 | Approved |
| 55 | Disorders of steroid metabolism | WP4523 and WP4524 | 37 | Approved |
| 60 | Lysosomal storage disorders | WP4153 | 25 | Approved |
| 66 | Congenital disorders of N-linked and O-linked glycosylation | WP4521 | 30 | Approved |
| 69 | Cerebral organic acidurias | WP4519 | 8 | Approved |
Information on Pathway Curation:
This Table provides an overview of which chapters have been covered by WikiPathways. Approved pathways are coloured blue; pathways which still need work (however are a part of the database) are coloured orange.
Tip:
Click on the arrows behind the Table headers to sort this table based on Chapter number (edition 4 and 5 available), title, WikiPathways reference and Curation Status.
Pathway Visualisations
View all digitized Pathways from the Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases by Blau et al. (see it on Scholia.)
How to add a pathway to the portal
The list of Featured Pathways is not static and can be updated at any time. If you know of a pathway that should be added, please contact Denise Slenter.
Data Analysis
With the pathways from the Blau book (as well as with other pathways on WikiPathways), various data analysis approaches can be performed.
For example scripts (in R), please visit PathwayAnalysisBlauBook.
The Figure on the left shows an example of network analysis with Cytoscape, where known drug-target interactions from DrugBank using the CyTargetLinker app have been added to the purine metabolism pathway.
Featured Pathway
|
Disorders of Folate Metabolism and Transport (Homo sapiens)  Disorders of Folate Metabolism and Transport |
| View all Featured Pathways for this Portal |
News
- Summer 2020: An overview of all covered chapter has been created on the main page
- Spring 2020: The Portal has been created
- Autumn 2019: Several chapters of the new book have already been digitized (but are embargoed)
