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Welcome to the COVID-19 Pathway Collection

This special subset of disease pathways is being highlighted during the current COVID-19 crisis. This content is released under a CC0 waiver to be freely used, reused and distributed. Let us know if you add a new pathway or want to recommend one for this collection.

The current list of authors and contributors of content of this portal: Friederike Ehrhart, Alex Pico, Kristina Hanspers, Amber Koning, Rex D A B, Penny Nymark, Denise Slenter, Caroline Thorn, the Reactome project, Chris Evelo, Lauren Dupuis, Matthew Conroy, Martina Kutmon, Marvin Martens, and many more.

We also thank the authors of all the cited articles (recursively).

Call to Action: COVID-19

We are helping to coordinate an international effort to build and curate pathway models relevant to the COVID-19 pandemic. Review the resources below to see how you can get involved.

IMPORTANT: WikiPathways is dedicated to FAIR standards. All content at WikiPathways is freely available for use and reuse by a CC0 waiver.

SARS-CoV-2 Pathways

SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.

Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

COVID-19, thrombosis and anticoagulation
Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

LDLRAD4 pathway in COVID-19
Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

Other coronaviruses: MERS, SARS-CoV, etc

Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

Host-pathogen interaction of human corona viruses - autophagy
Host-pathogen interaction of human corona viruses - apoptosis
SARS coronavirus and innate immunity
ER stress response in Coronavirus infection
Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
Host-pathogen interaction of human corona viruses - MAPK signaling
Host-pathogen interaction of human corona viruses - Interferon induction

More about ACE2

ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins (Reactome)
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