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Welcome to the COVID-19 Pathway Collection

This special subset of disease pathways is being highlighted during the current COVID-19 crisis. This content is released under a CC0 waiver to be freely used, reused and distributed. Let us know if you add a new pathway or want to recommend one for this collection.

Call to Action: COVID-19

We are helping to coordinate an international effort to build and curate pathway models relevant to the COVID-19 pandemic. Review the resources below to see how you can get involved.

SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with muliple members of the Cullin 2 ubiquitin ligase complex.

Autophagy during CoV infection
Integrative stress response in SARS-CoV-2 infection
Host-pathogen interaction of human corona viruses - autophagy
Host-pathogen interaction of human corona viruses - apoptosis
Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

Host-pathogen interaction of human corona viruses - ER stress
Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

Host-pathogen interaction of human corona viruses - MAPK signaling

More about ACE2

ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins (Reactome)
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