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To fuel uncontrolled cell proliferation, cancer cells adjust energy metabolism. First observed by Otto Warburg, even in the presence of oxygen, cancer cells can reprogram their glucose metabolism, and thus their energy production, by limiting their energy metabolism largely to glycolysis, leading to a state that has been termed “aerobic glycolysis.” To compensate for the lower efficiency of ATP production by glycolysis, as compared to oxidative phosphorylation, cancer cells compensate, for example by up-reglating glucose transporters. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)

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