Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MET in type 1 papillary renal cell carcinoma (Homo sapiens)

MET in type 1 papillary renal cell carcinoma
MET in type 1 papillary renal cell carcinoma
Evading growth suppressors

Senescence and Autophagy in Cancer (Homo sapiens)

Senescence and Autophagy in Cancer
Senescence and Autophagy in Cancer
Activating invasion and metastasis

MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

MFAP5-mediated ovarian cancer cell motility and invasiveness
MFAP5-mediated ovarian cancer cell motility and invasiveness
Enabling replicative immortality

Notch Signaling Pathway Netpath (Homo sapiens)

Notch Signaling Pathway Netpath
Notch Signaling Pathway Netpath
Inducing angiogenesis

Hedgehog Signaling Pathway (Homo sapiens)

Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Resisting cell death

Apoptosis (Homo sapiens)

Apoptosis
Apoptosis
Deregulating cellular energetics

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (Homo sapiens)

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Genome instability and mutation

DNA Damage Response (only ATM dependent) (Homo sapiens)

DNA Damage Response (only ATM dependent)
DNA Damage Response (only ATM dependent)
Tumor promoting inflammation

Chemokine signaling pathway (Homo sapiens)

Chemokine signaling pathway
Chemokine signaling pathway
Avoiding immune destruction

Role of Altered Glycolysation of MUC1 in Tumour Microenvironment (Homo sapiens)

Role of Altered Glycolysation of MUC1 in Tumour Microenvironment
Role of Altered Glycolysation of MUC1 in Tumour Microenvironment
Therapeutics

Interactions between immune cells and microRNAs in tumor microenvironment (Homo sapiens)

Interactions between immune cells and microRNAs in tumor microenvironment
Interactions between immune cells and microRNAs in tumor microenvironment

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools