Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MAPK Signaling Pathway (Homo sapiens)

MAPK Signaling Pathway
MAPK Signaling Pathway
Evading growth suppressors

Retinoblastoma (RB) in Cancer (Homo sapiens)

Retinoblastoma (RB) in Cancer
Retinoblastoma (RB) in Cancer
Activating invasion and metastasis

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway (Homo sapiens)

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Enabling replicative immortality

Wnt Signaling Pathway (Homo sapiens)

Wnt Signaling Pathway
Wnt Signaling Pathway
Inducing angiogenesis

PDGF Pathway (Homo sapiens)

PDGF Pathway
PDGF Pathway
Resisting cell death

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (Homo sapiens)

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Deregulating cellular energetics

Glycolysis and Gluconeogenesis (Homo sapiens)

Glycolysis and Gluconeogenesis
Glycolysis and Gluconeogenesis
Genome instability and mutation

Methylation Pathways (Homo sapiens)

Methylation Pathways
Methylation Pathways
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

Photodynamic therapy-induced NF-kB survival signaling (Homo sapiens)

Photodynamic therapy-induced NF-kB survival signaling
Photodynamic therapy-induced NF-kB survival signaling

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools