Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MAPK Signaling Pathway (Homo sapiens)

MAPK Signaling Pathway
MAPK Signaling Pathway
Evading growth suppressors

G1 to S cell cycle control (Homo sapiens)

G1 to S cell cycle control
G1 to S cell cycle control
Activating invasion and metastasis

H19 action Rb-E2F1 signaling and CDK-β-catenin activity (Homo sapiens)

H19 action Rb-E2F1 signaling and CDK-β-catenin activity
H19 action Rb-E2F1 signaling and CDK-β-catenin activity
Enabling replicative immortality

Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds (Homo sapiens)

Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
Inducing angiogenesis

Angiogenesis (Homo sapiens)

Angiogenesis
Angiogenesis
Resisting cell death

miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)

miRNA regulation of p53 pathway in prostate cancer
miRNA regulation of p53 pathway in prostate cancer
Deregulating cellular energetics

Fatty Acid Beta Oxidation (Homo sapiens)

Fatty Acid Beta Oxidation
Fatty Acid Beta Oxidation
Genome instability and mutation

ATR Signaling (Homo sapiens)

ATR Signaling
ATR Signaling
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

Photodynamic therapy-induced NF-kB survival signaling (Homo sapiens)

Photodynamic therapy-induced NF-kB survival signaling
Photodynamic therapy-induced NF-kB survival signaling

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools