Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

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Cancer Hallmark Categories

Sustaining proliferative signaling

Ras Signaling (Homo sapiens)

Ras Signaling
Ras Signaling
Evading growth suppressors

Tumor suppressor activity of SMARCB1 (Homo sapiens)

Tumor suppressor activity of SMARCB1
Tumor suppressor activity of SMARCB1
Activating invasion and metastasis

Integrin-mediated Cell Adhesion (Homo sapiens)

Integrin-mediated Cell Adhesion
Integrin-mediated Cell Adhesion
Enabling replicative immortality

Wnt Signaling Pathway (Homo sapiens)

Wnt Signaling Pathway
Wnt Signaling Pathway
Inducing angiogenesis

PDGF Pathway (Homo sapiens)

PDGF Pathway
PDGF Pathway
Resisting cell death

TP53 Network (Homo sapiens)

TP53 Network
TP53 Network
Deregulating cellular energetics

Target Of Rapamycin (TOR) Signaling (Homo sapiens)

Target Of Rapamycin (TOR) Signaling
Target Of Rapamycin (TOR) Signaling
Genome instability and mutation

ATM Signaling Network in Development and Disease (Homo sapiens)

ATM Signaling Network in Development and Disease
ATM Signaling Network in Development and Disease
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Type II interferon signaling (IFNG) (Homo sapiens)

Type II interferon signaling (IFNG)
Type II interferon signaling (IFNG)
Therapeutics

Fluoropyrimidine Activity (Homo sapiens)

Fluoropyrimidine Activity
Fluoropyrimidine Activity

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools