Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

Translation inhibitors in chronically activated PDGFRA cells (Homo sapiens)

Translation inhibitors in chronically activated PDGFRA cells
Translation inhibitors in chronically activated PDGFRA cells
Evading growth suppressors

TGF-beta Receptor Signaling (Homo sapiens)

TGF-beta Receptor Signaling
TGF-beta Receptor Signaling
Activating invasion and metastasis

Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

Epithelial to mesenchymal transition in colorectal cancer
Epithelial to mesenchymal transition in colorectal cancer
Enabling replicative immortality

Notch Signaling Pathway Netpath (Homo sapiens)

Notch Signaling Pathway Netpath
Notch Signaling Pathway Netpath
Inducing angiogenesis

Angiogenesis (Homo sapiens)

Angiogenesis
Angiogenesis
Resisting cell death

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (Homo sapiens)

PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Deregulating cellular energetics

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (Homo sapiens)

TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Genome instability and mutation

Non-homologous end joining (Homo sapiens)

Non-homologous end joining
Non-homologous end joining
Tumor promoting inflammation

IL-1 signaling pathway (Homo sapiens)

IL-1 signaling pathway
IL-1 signaling pathway
Avoiding immune destruction

Type II interferon signaling (IFNG) (Homo sapiens)

Type II interferon signaling (IFNG)
Type II interferon signaling (IFNG)
Therapeutics

Photodynamic therapy-induced HIF-1 survival signaling (Homo sapiens)

Photodynamic therapy-induced HIF-1 survival signaling
Photodynamic therapy-induced HIF-1 survival signaling

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools