Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

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Cancer Hallmark Categories

Sustaining proliferative signaling

MAPK Signaling Pathway (Homo sapiens)

MAPK Signaling Pathway
MAPK Signaling Pathway
Evading growth suppressors

TGF-beta Receptor Signaling (Homo sapiens)

TGF-beta Receptor Signaling
TGF-beta Receptor Signaling
Activating invasion and metastasis

Integrin-mediated Cell Adhesion (Homo sapiens)

Integrin-mediated Cell Adhesion
Integrin-mediated Cell Adhesion
Enabling replicative immortality

Wnt Signaling (Homo sapiens)

Wnt Signaling
Wnt Signaling
Inducing angiogenesis

PDGF Pathway (Homo sapiens)

PDGF Pathway
PDGF Pathway
Resisting cell death

Target Of Rapamycin (TOR) Signaling (Homo sapiens)

Target Of Rapamycin (TOR) Signaling
Target Of Rapamycin (TOR) Signaling
Deregulating cellular energetics

Fatty Acid Beta Oxidation (Homo sapiens)

Fatty Acid Beta Oxidation
Fatty Acid Beta Oxidation
Genome instability and mutation

DNA IR-damage and cellular response via ATR (Homo sapiens)

DNA IR-damage and cellular response via ATR
DNA IR-damage and cellular response via ATR
Tumor promoting inflammation

Cytokines and Inflammatory Response (Homo sapiens)

Cytokines and Inflammatory Response
Cytokines and Inflammatory Response
Avoiding immune destruction

Interferon type I signaling pathways (Homo sapiens)

Interferon type I signaling pathways
Interferon type I signaling pathways
Therapeutics

LncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

LncRNA-mediated mechanisms of therapeutic resistance
LncRNA-mediated mechanisms of therapeutic resistance

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Featured Pathways

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Assay Portal

CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data

Resources

Learn how they incorpated WikiPathways images with custom links on their site.

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links

Personal tools