Portal:COVID-19/FeaturedPathways

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SARS-CoV-2 Pathways

SARS-CoV-2 and COVID-19 Pathway

Collaborative project for curation of biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

Hijack of Ubiquitination by SARS-CoV-2

SARS-CoV-2 includes a novel Orf10 that interacts with multiple members of the Cullin 2 ubiquitin ligase complex.

Type I Interferon Induction and Signaling During SARS-CoV-2 Infection

The induction and signaling of type I interferon with specific SARS-CoV-2 protein and relevant drug.

COVID-19, thrombosis and anticoagulation
Activation of NLRP3 Inflammasome by SARS-CoV-2

Orf3a from SARS-CoV has been shown to bind TRAF3 and activate the NLRP3 inflammasome.

SARS-CoV-2 and Angiotensin-converting enzyme 2 (ACE2) receptor : Molecular mechanisms and potential therapeutic target
COVID-19 AOP

Experimental pathway to investigate overlap of virus-host interaction and adverse outcome pathways

nsp9/nsp10-mediated SARS-CoV-2 pathogenesis

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

LDLRAD4 pathway in COVID-19
Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)
STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)

Other coronaviruses: MERS, SARS-CoV, etc

Coronavirus lipid metabolism

Lipid metabolism alternations that are related to infection by the corona virus.

Host-pathogen interaction of human corona viruses - autophagy
Host-pathogen interaction of human corona viruses - apoptosis
SARS coronavirus and innate immunity
ER stress response in Coronavirus infection
Downregulation of ACE2 expression by SARS-CoV infection and SARS-CoV Spike protein
Host-pathogen interaction of human corona viruses - MAPK signaling
Host-pathogen interaction of human corona viruses - Interferon induction
Deregulation of the Renin Angiotensin system by Sars-CoV infection

More about ACE2

ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins (Reactome)

List of featured pathways:

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