Pathway Talk:WP619

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Pathway Incorrect (2)

I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b).  

I've looked at the paper this pathway is based on and I think they made a mistake. STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade. I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.

Hi Shamith,

Thank you for reviewing the pathway. You are correct that in this particular case, interactions are not annotated. WikiPathways supports two different ways of adding supporting information to interactions: As an annotated interaction from an interaction database, and by adding a literature reference directly to the interaction.

Since you have expert knowledge in the area of interferon signaling, I would highly recommend that you edit the pathway to correct any incorrect content. After logging in to WikiPathways, simply click "launch editor" under the pathway diagram.

Regards,

Kristina

Hi Shamith,

Thank you for reviewing the pathway. You are correct that in this particular case, interactions are not annotated. WikiPathways supports two different ways of adding supporting information to interactions: As an annotated interaction from an interaction database, and by adding a literature reference directly to the interaction.

Since you have expert knowledge in the area of interferon signaling, I would highly recommend that you edit the pathway to correct any incorrect content. After logging in to WikiPathways, simply click "launch editor" under the pathway diagram.

Regards,

Kristina

Pathway Incorrect (1)

I've worked on immune and interferon signaling for years and STAT2 isn't activated by IFNg signaling. STAT2 and ISGF3 complex (STAT1:STAT2:IRF9) formation is unique to type I IFN signaling IFNa/b).  I've looked at the paper this pathway is based on and  I think they made a mistake.  STAT2 can be a transcriptional target of IFNG but is never a part of the signaling cascade.

I guess one of the biggest weaknesses of community derived pathway resources is that lack of evidence/provenance for each link between molecules in the signaling cascade.

Is this pathway complete? (9)

There have been no changes to this discussion for at least 30 days. If it is concluded, you may want to write a summary.

Hi Thomas, looks like this pathway is complete. If so, I will include it in the next GenMAPP archive. Please confirm.

Thanks,

Kristina

Hi Kristina,

Yes, it's complete and matches the pathway in the article, so please go ahead and include it in GenMAPP.

Thomas

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