MAPK Signaling Pathway (Bos taurus)

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Scaffold1-5, 8-1176LegendCalcium channelsActivating mutationCalcium channelsHeteromeric G-proteinProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTRAF6MEF2CPSRFRPS6KA3PMAP2K3PELK4PRAP1APCRKIL1APDGFBAKT3ECSITMAP3K13RASGRP4MAP3K7PMAPK9PGRB2MKNK1PDUSP1STMN1PELK1PPPEGFRPPP3CBPPP3CCMAP4K1NFATC1PARRB2MAPTPRASGRP1RAP1BPCD14IKBKGBDNFDAXXMAPK10PTNFMOSSTK4MAPK14PIKBKBPPARRB1LRRK2CASP3FLNAPRKACAMAPKAPK2PTNFRSF1AMAP3K14HSPB1PMAP3K20GNA12TGFB1MAP3K1PMAP3K2PMAXPDUSP10RASGRF2MAP4K4PDGFRBMAP3K7IP1MAP3K4GADD45AWnt signaling pathwayMAP2K5CDC25BPIL1R1RAC2PRKCDPPP5CMAP2K1PPRAC1PTPN7IL1R2TAB2TGFBR1MAPK1PPPTPRRPTPN5PLA2G4DPBRAFNTRK1ATF2PMAP2K4PLPSFOSPRKCGMYCSOS2TGFB2ELK1PMAPK7PDUSP4CACNG3ApoptosisHSPA8MAPK12PMAPK8IP1IP3PPM1ACa2+IL1BELK4PTRAF2MAPK13PTAOK1MAP2K6PDUSP8AKT2MAPKAPK5PRASA2DUSP7PPP3R2FGFR1TGFB3PPP3CAEGFDDIT3PMAP3K6MAP3K8NGFCRKLTAOK2cAMPMAPK3PPMAPK8PNR4A1PCell cyclePRKCAATF4PNTF4PDGFAATF4PNTRK2FASLGPDGFRBPPM1BFGFR2CDC42FGFR3LAMTOR3FGFR4JUNPPJUNDSOS1PRRASHRASPPRPS6KA5PMAP3K12TP53PRRAS2PNFKB1GNG12PLA2G4CPNF1RASGRP2AKT1p53 signaling pathwayRASGRP3RASGRP4RASA1RASGRF1HSPA6Ca2+NTF3RAPGEF2Phosphatidylinositolsignaling systemPRKACBHSPA1APRKACGSTK3DUSP3MAP4K3CHUKPTGFBR2NFKB2MAP4K2RELAMAP2K7PRELBPPP3R1DUSP9NLKPDUSP2DAGDUSP16FASMKNK2PPLA2G4APNFATC3PMAP3K5PMAP3K11PTAOK3DUSP6MAP2K2PPPPP5D1MAPK11PRPS6KA4PMAPKAPK3PRAC3MAPK8IP2MAPK8IP3FLNBFLNCHSPA1AHSPA1LHSPA2MRASPNRASPKRASPRAF1PPLA2G4FPLA2G4BPPPLA2G4EPCACNG2CACNG5CACNG4CACNA2D3CACNG8CACNG7CACNG6CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1SCACNA2D1CACNB1CACNB2CACNB3CACNB4CACNG1CACNA1ICACNA1HCACNA1GCACNA2D2CACNA2D4FGF4FGF1FGF2FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGF10FGF11FGF12FGF13FGF14FGF20FGF21FGF22FGF23FGF18FGF17FGF16FGF19Fibroblast growth factorsFibroblast growthfactorsPAK2PAK1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  2. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  3. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  4. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  5. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  6. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC
  7. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  8. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  9. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  10. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  11. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107080view14:16, 17 September 2019MaintBotChEBI identifier normalization
105986view11:51, 16 August 2019MaintBotHMDB identifier normalization
105687view20:57, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96305view18:29, 7 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95777view14:31, 19 January 2018MkutmonHomology conversion update
80676view15:21, 30 June 2015Mkutmonhomology conversion
72096view21:37, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
67448view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
63314view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
48136view05:54, 9 May 2012MaintBotUpdating from human to fix xref duplication
40495view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35662view22:24, 12 February 2010KhanspersAdded description and lit refs
33739view23:55, 8 December 2009MaintBotAutomatic update of empty xrefs
33639view10:06, 1 December 2009MaintBotRemoved group label
31644view22:27, 13 August 2009MaintBotFixed text labels
30567view22:05, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:207
AKT2GeneProductENSBTAG00000001400 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:208
AKT3GeneProductENSBTAG00000017788 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10000
ARRB1GeneProductENSBTAG00000020485 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:408
ARRB2GeneProductENSBTAG00000035587 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:409
ATF2GeneProductENSBTAG00000002295 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1386
ATF4GeneProductENSBTAG00000017462 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:468
ApoptosisPathwayWP254 (WikiPathways)
BDNFGeneProductENSBTAG00000008134 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:627
BRAFGeneProductENSBTAG00000021761 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:673
CACNA1AGeneProductENSBTAG00000014828 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000141837
CACNA1BGeneProductENSBTAG00000007882 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000148408
CACNA1CGeneProductENSBTAG00000010660 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000151067
CACNA1DGeneProductENSBTAG00000010026 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000157388
CACNA1EGeneProductENSBTAG00000020887 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000198216
CACNA1FGeneProductENSBTAG00000016097 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000102001
CACNA1GGeneProductENSBTAG00000009835 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000006283
CACNA1HGeneProductENSBTAG00000026461 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000196557
CACNA1IGeneProductENSBTAG00000045610 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000100346
CACNA1SGeneProductENSBTAG00000047491 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000081248
CACNA2D1GeneProductENSBTAG00000020569 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000153956
CACNA2D2GeneProductENSBTAG00000009489 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000007402
CACNA2D3GeneProductENSBTAG00000013117 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000157445
CACNA2D4GeneProductENSBTAG00000021994 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000151062
CACNB1GeneProductENSBTAG00000002036 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000067191
CACNB2GeneProductENSBTAG00000022000 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000165995
CACNB3GeneProductENSBTAG00000021808 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000167535
CACNB4GeneProductENSBTAG00000002297 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000182389
CACNG1GeneProductENSBTAG00000007547 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000108878
CACNG2GeneProductENSBTAG00000010865 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000166862
CACNG3GeneProductENSBTAG00000001404 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = H:CACNG3
CACNG4GeneProductENSBTAG00000000589 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000075461
CACNG5GeneProductENSBTAG00000012311 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000075429
CACNG6GeneProductENSBTAG00000021657 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000130433
CACNG7GeneProductENSBTAG00000007506 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000105605
CACNG8GeneProductENSBTAG00000007509 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000142408
CASP3GeneProductENSBTAG00000015874 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:836
CD14GeneProductENSBTAG00000015032 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:929
CDC25BGeneProductENSBTAG00000008436 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:994
CDC42GeneProductNo homologues found for original id L:998
CHUKGeneProductENSBTAG00000007591 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341
CRKGeneProductENSBTAG00000005665 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1398
CRKLGeneProductENSBTAG00000045548 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1399
Ca2+MetaboliteHMDB0000464 (HMDB)
Cell cyclePathwayWP179 (WikiPathways)
DAGMetaboliteCHEBI:18035 (ChEBI)
DAXXGeneProductENSBTAG00000016830 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1616
DDIT3GeneProductENSBTAG00000031544 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1649
DUSP10GeneProductENSBTAG00000001729 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11221
DUSP16GeneProductENSBTAG00000010763 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000111266
DUSP1GeneProductENSBTAG00000013863 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1843
DUSP2GeneProductENSBTAG00000020350 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000158050
DUSP3GeneProductENSBTAG00000003966 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000108861
DUSP4GeneProductENSBTAG00000044208 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1846
DUSP6GeneProductENSBTAG00000004587 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1848
DUSP7GeneProductENSBTAG00000021912 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1849
DUSP8GeneProductENSBTAG00000030999 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000184545
DUSP9GeneProductENSBTAG00000008319 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000130829
ECSITGeneProductENSBTAG00000015049 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51295
EGFGeneProductNo homologues found for original id L:1950
EGFRGeneProductENSBTAG00000011628 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1956
ELK1GeneProductENSBTAG00000015817 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000158711
FASGeneProductENSBTAG00000010785 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:355
FASLGGeneProductENSBTAG00000032808 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:356
FGF10GeneProductNo homologues found for original id En:ENSG00000070193
FGF11GeneProductENSBTAG00000019241 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000161958
FGF12GeneProductENSBTAG00000012413 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000114279
FGF13GeneProductENSBTAG00000020194 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000129682
FGF14GeneProductNo homologues found for original id En:ENSG00000102466
FGF16GeneProductENSBTAG00000006722 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000196468
FGF17GeneProductENSBTAG00000046951 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000158815
FGF18GeneProductENSBTAG00000000128 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000156427
FGF19GeneProductENSBTAG00000017285 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000162344
FGF1GeneProductENSBTAG00000005198 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000113578
FGF20GeneProductENSBTAG00000044043 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000078579
FGF21GeneProductENSBTAG00000011624 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000105550
FGF22GeneProductENSBTAG00000027357 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000070388
FGF23GeneProductENSBTAG00000030343 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000118972
FGF2GeneProductENSBTAG00000005691 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
FGF3GeneProductENSBTAG00000008623 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000186895
FGF4GeneProductENSBTAG00000012563 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388
FGF5GeneProductENSBTAG00000017348 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000138675
FGF6GeneProductENSBTAG00000006800 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000111241
FGF7GeneProductENSBTAG00000004013 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000140285
FGF8GeneProductENSBTAG00000001530 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
FGF9GeneProductENSBTAG00000048237 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000102678
FGFR1GeneProductENSBTAG00000015457 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2260
FGFR2GeneProductENSBTAG00000014064 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000066468
FGFR3GeneProductENSBTAG00000007164 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000068078
FGFR4GeneProductENSBTAG00000010543 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000160867
FLNAGeneProductENSBTAG00000011190 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2316
FLNBGeneProductENSBTAG00000022004 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000136068
FLNCGeneProductENSBTAG00000006253 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000128591
FOSGeneProductENSBTAG00000004322 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2353
GADD45AGeneProductENSBTAG00000013860 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1647
GNA12GeneProductENSBTAG00000017871 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2768
GNG12GeneProductENSBTAG00000035697 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000172380
GRB2GeneProductENSBTAG00000004736 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2885
HRASGeneProductENSBTAG00000046644 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000174775
HSPA1AGeneProductENSBTAG00000025441 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000204388
HSPA1LGeneProductENSBTAG00000025442 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000204390
HSPA2GeneProductNo homologues found for original id En:ENSG00000126803
HSPA6GeneProductNo homologues found for original id En:ENSG00000173110
HSPA8GeneProductENSBTAG00000013162 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3312
HSPB1GeneProductENSBTAG00000011969 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3315
IKBKBGeneProductENSBTAG00000007599 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3551
IKBKGGeneProductENSBTAG00000006268 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8517
IL1AGeneProductENSBTAG00000010349 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3552
IL1BGeneProductENSBTAG00000001321 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1GeneProductENSBTAG00000005273 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3554
IL1R2GeneProductENSBTAG00000006343 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7850
IP3MetaboliteCHEBI:16595 (ChEBI)
JUNDGeneProductNo homologues found for original id L:3727
JUNGeneProductENSBTAG00000004037 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3725
KRASGeneProductENSBTAG00000009778 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3845
LAMTOR3GeneProductENSBTAG00000007923 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8649
LPSMetaboliteCHEBI:16412 (ChEBI)
LRRK2GeneProductENSBTAG00000016260 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000188906
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6416
MAP2K5GeneProductENSBTAG00000000218 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6GeneProductENSBTAG00000001609 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5608
MAP2K7GeneProductENSBTAG00000010639 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5609
MAP3K11GeneProductENSBTAG00000004114 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4296
MAP3K12GeneProductENSBTAG00000020758 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7786
MAP3K13GeneProductENSBTAG00000017103 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9175
MAP3K14GeneProductENSBTAG00000007084 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K20GeneProductENSBTAG00000001083 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51776
MAP3K2GeneProductENSBTAG00000004216 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10746
MAP3K4GeneProductENSBTAG00000020079 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4216
MAP3K5GeneProductENSBTAG00000009065 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4217
MAP3K6GeneProductENSBTAG00000010254 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9064
MAP3K7GeneProductENSBTAG00000002625 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6885
MAP3K7IP1GeneProductENSBTAG00000019828 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10454
MAP3K8GeneProductENSBTAG00000011600 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1326
MAP4K1GeneProductENSBTAG00000021145 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11184
MAP4K2GeneProductENSBTAG00000001037 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000168067
MAP4K3GeneProductENSBTAG00000016442 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8491
MAP4K4GeneProductENSBTAG00000013023 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9448
MAPK10GeneProductENSBTAG00000020048 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5602
MAPK11GeneProductENSBTAG00000030182 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000185386
MAPK12GeneProductENSBTAG00000019574 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6300
MAPK13GeneProductENSBTAG00000010007 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5603
MAPK14GeneProductENSBTAG00000020783 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5595
MAPK7GeneProductENSBTAG00000001014 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5598
MAPK8GeneProductENSBTAG00000007876 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5599
MAPK8IP1GeneProductENSBTAG00000000317 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000121653
MAPK8IP2GeneProductENSBTAG00000030179 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000008735
MAPK8IP3GeneProductENSBTAG00000002211 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000138834
MAPK9GeneProductENSBTAG00000004709 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5601
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9261
MAPKAPK3GeneProductENSBTAG00000016532 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000114738
MAPKAPK5GeneProductENSBTAG00000009346 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8550
MAPTGeneProductENSBTAG00000017512 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4137
MAXGeneProductENSBTAG00000017994 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4149
MEF2CGeneProductENSBTAG00000020701 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4208
MKNK1GeneProductENSBTAG00000019933 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8569
MKNK2GeneProductENSBTAG00000018049 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000099875
MOSGeneProductENSBTAG00000019145 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4342
MRASGeneProductENSBTAG00000001497 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22808
MYCGeneProductENSBTAG00000008409 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609
NF1GeneProductENSBTAG00000011829 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000196712
NFATC1GeneProductENSBTAG00000000656 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4772
NFATC3GeneProductENSBTAG00000004368 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000072736
NFKB1GeneProductENSBTAG00000020270 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2GeneProductENSBTAG00000006017 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000077150
NGFGeneProductENSBTAG00000007446 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000134259
NLKGeneProductENSBTAG00000014825 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51701
NR4A1GeneProductENSBTAG00000000507 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3164
NRASGeneProductENSBTAG00000046797 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4893
NTF3GeneProductENSBTAG00000010223 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000185652
NTF4GeneProductENSBTAG00000047078 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950
NTRK1GeneProductENSBTAG00000003060 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4914
NTRK2GeneProductENSBTAG00000010647 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000148053
PAK1GeneProductENSBTAG00000010191 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5058
PAK2GeneProductENSBTAG00000047856 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5062
PDGFAGeneProductENSBTAG00000014541 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000197461
PDGFBGeneProductENSBTAG00000021697 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5155
PDGFRBGeneProductENSBTAG00000002804 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721
PLA2G4AGeneProductENSBTAG00000013298 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000116711
PLA2G4BGeneProductENSBTAG00000006784 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000243708
PLA2G4CGeneProductNo homologues found for original id En:ENSG00000105499
PLA2G4DGeneProductENSBTAG00000005268 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000159337
PLA2G4EGeneProductENSBTAG00000021924 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000188089
PLA2G4FGeneProductENSBTAG00000032068 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000168907
PPM1AGeneProductENSBTAG00000031088 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5494
PPM1BGeneProductENSBTAG00000000223 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5495
PPP3CAGeneProductENSBTAG00000016005 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5530
PPP3CBGeneProductENSBTAG00000046024 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5532
PPP3CCGeneProductENSBTAG00000020133 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5533
PPP3R1GeneProductENSBTAG00000010619 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5534
PPP3R2GeneProductNo homologues found for original id L:5535
PPP5CGeneProductENSBTAG00000008014 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5536
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKACAGeneProductENSBTAG00000006642 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5566
PRKACBGeneProductENSBTAG00000011953 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000142875
PRKACGGeneProductNo homologues found for original id En:ENSG00000165059
PRKCAGeneProductENSBTAG00000001061 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PRKCDGeneProductENSBTAG00000008719 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5580
PRKCGGeneProductENSBTAG00000013550 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5582
PTPN5GeneProductENSBTAG00000020257 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84867
PTPN7GeneProductENSBTAG00000003016 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5778
PTPRRGeneProductENSBTAG00000015311 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5801
Phosphatidylinositol signaling systemPathway
RAC1GeneProductENSBTAG00000009233 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5879
RAC2GeneProductENSBTAG00000011043 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5880
RAC3GeneProductNo homologues found for original id En:ENSG00000169750
RAF1GeneProductENSBTAG00000004514 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5894
RAP1AGeneProductENSBTAG00000014710 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5908
RAPGEF2GeneProductENSBTAG00000012450 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000109756
RASA1GeneProductENSBTAG00000009565 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5921
RASA2GeneProductENSBTAG00000015413 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5922
RASGRF1GeneProductENSBTAG00000019940 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000058335
RASGRF2GeneProductENSBTAG00000030259 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5924
RASGRP1GeneProductENSBTAG00000021872 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10125
RASGRP2GeneProductENSBTAG00000001029 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000068831
RASGRP3GeneProductENSBTAG00000008006 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000152689
RASGRP4GeneProductENSBTAG00000006998 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000171777
RELAGeneProductENSBTAG00000013895 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
RELBGeneProductENSBTAG00000038428 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000104856
RPS6KA3GeneProductENSBTAG00000017639 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6197
RPS6KA4GeneProductENSBTAG00000039153 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000162302
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9252
RRAS2GeneProductENSBTAG00000011905 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000133818
RRASGeneProductENSBTAG00000020983 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000126458
SOS1GeneProductENSBTAG00000011643 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000115904
SOS2GeneProductENSBTAG00000005550 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6655
SRFGeneProductENSBTAG00000012777 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6722
STK3GeneProductENSBTAG00000026234 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6788
STK4GeneProductENSBTAG00000003257 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000101109
STMN1GeneProductENSBTAG00000013761 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3925
TAB2GeneProductENSBTAG00000013454 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23118
TAOK1GeneProductENSBTAG00000000827 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57551
TAOK2GeneProductENSBTAG00000017422 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9344
TAOK3GeneProductENSBTAG00000012550 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000135090
TGFB1GeneProductENSBTAG00000020457 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7040
TGFB2GeneProductENSBTAG00000005359 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7042
TGFB3GeneProductENSBTAG00000012004 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7043
TGFBR1GeneProductENSBTAG00000018035 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR2GeneProductENSBTAG00000019832 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7048
TNFGeneProductENSBTAG00000025471 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
TNFRSF1AGeneProductENSBTAG00000004211 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = En:ENSG00000067182
TP53GeneProductENSBTAG00000001069 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157
TRAF2GeneProductENSBTAG00000010497 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7186
TRAF6GeneProductENSBTAG00000036009 (Ensembl) Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7189
Wnt signaling pathwayPathwayWP428 (WikiPathways)
cAMPMetaboliteHMDB0000058 (HMDB)
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions
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