EPO Receptor Signaling (Bos taurus)

From WikiPathways

Jump to: navigation, search
EPORJAK2SRCEPOR1, 2PBox-1PPPPPPPPPPY343Y479Box-2DNACell membraneY343Y460PPBox-2Box-1PY431GRB2EPOPDK1PIK3CGSTAT1MAP2K1SHC1AKT1MAPK3MAPK1MAP2K2EPOSOCS1STAT5BCISHSTAT5ASTAT3STAT3STAT1PTPRCPTPRUPPPGRB2RAF1SOS1IRS2JAK2IRS1RASA1RAF1SOS1RASA1


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia This pathway is based on ScienceSlides.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP581(67199) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed
  2. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed

History

View all...
CompareRevisionActionTimeUserComment
80789view15:26, 30 June 2015Mkutmonhomology conversion
67202view10:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63457view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40592view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35095view12:58, 11 February 2010Thomasadded literature
33637view10:06, 1 December 2009MaintBotRemoved group label
30565view22:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
CISHGeneProductENSBTAG00000022622 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
EPOGeneProductENSBTAG00000003430 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056
EPORGeneProductENSBTAG00000008197 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057
GRB2GeneProductENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
IRS1GeneProductENSBTAG00000021308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
IRS2GeneProductENSBTAG00000012019 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
JAK2GeneProductENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
PDK1GeneProductENSBTAG00000016836 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
PIK3CGGeneProductENSBTAG00000020848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PTPRCGeneProductENSBTAG00000023144 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788
PTPRUGeneProductENSBTAG00000012848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASA1GeneProductENSBTAG00000009565 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
SHC1GeneProductENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SOCS1GeneProductENSBTAG00000004386 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOS1GeneProductENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1GeneProductENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AGeneProductENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BGeneProductENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777

Annotated Interactions

No annotated interactions
Personal tools