Prostaglandin Synthesis and Regulation (Bos taurus)

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1CytoplasmprolactinreleaseInactive MetabolitesPG SynthasesCortisoneHSD11B2TBXAS1PTGER4PTGER3PTGDRPGF2aCortisolPGHS-2EDN1ANXA3HPGDPGF2aPRLANXA1EP1ANXA4FPProgesteronePTGIRPTGISTXA2SCGB1A1S100A6ANXA2ANXA5Gq signalingpathwayPTGER2PGE2CalciumPGI2CalciumPTGS1ANXA6PTGDSProstaglandin H2Cell MembranePhospholipidsPLA2G4AEDNRAHSD11B1CortisolEDNRBArachidonic AcidS100A10ANXA8CYP11A1


Description

A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue.[1] Prostaglandins are not hormones, but autocrine or paracrine, which are locally acting messenger molecules. They differ from hormones in that they are not produced at a discrete site but in many places throughout the human body. Also, their target cells are present in the immediate vicinity of the site of their secretion (of which there are many).

The prostaglandins, together with the thromboxanes and prostacyclins, form the prostanoid class of fatty acid derivatives, a subclass of eicosanoids.

Source: Wikipedia (wikipedia:Prostaglandin)

Comments

GenMAPP notes 
Adapted from Gross, G et al. 2000, Society for Gynecologic Investigation; 7:88-95
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP98(72088) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Gross G, Imamura T, Muglia LJ; ''Gene knockout mice in the study of parturition.''; J Soc Gynecol Investig, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
105989view11:51, 16 August 2019MaintBotHMDB identifier normalization
80872view15:29, 30 June 2015Mkutmonhomology conversion
71430view19:03, 17 October 2013MaintBotAutomated update of data sources
63464view17:19, 10 May 2013MaintBotUpdated to 2013 gpml schema
40599view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33836view00:30, 9 December 2009MaintBotAutomatic update of empty xrefs
33636view10:06, 1 December 2009MaintBotRemoved group label
31642view22:27, 13 August 2009MaintBotFixed text labels
30564view22:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ANXA1GeneProductENSBTAG00000015978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:301
ANXA2GeneProductENSBTAG00000009615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:302
ANXA3GeneProductENSBTAG00000010153 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:306
ANXA4GeneProductENSBTAG00000001105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:307
ANXA5GeneProductENSBTAG00000021746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:308
ANXA6GeneProductENSBTAG00000014809 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:309
ANXA8GeneProductENSBTAG00000018499 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:244
Arachidonic AcidMetabolite506-32-1 (CAS)
CYP11A1GeneProductENSBTAG00000006934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1583
CalciumMetaboliteHMDB0000464 (HMDB)
Cell Membrane PhospholipidsMetabolite
CortisolMetabolite50-23-7 (CAS)
EDN1GeneProductENSBTAG00000008096 (Ensembl)
  • PMID: 1474344
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1906
EDNRAGeneProductENSBTAG00000013674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1909
EDNRBGeneProductENSBTAG00000005299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1910
EP1GeneProductENSBTAG00000017041 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5731
FPGeneProductENSBTAG00000015902 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5737
Gq signaling pathwayPathwayWP35 (WikiPathways)
HPGDGeneProductENSBTAG00000025942 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3248
HSD11B1GeneProductENSBTAG00000015086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3290
HSD11B2GeneProductENSBTAG00000005685 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3291
PGE2MetaboliteHMDB0003175 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
PGI2MetaboliteHMDB0001335 (HMDB)
PLA2G4AGeneProductENSBTAG00000013298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5321
PRLGeneProductENSBTAG00000015274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5617
PTGDRGeneProductENSBTAG00000006703 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5729
PTGDSGeneProductENSBTAG00000015074 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5730
PTGER2GeneProductENSBTAG00000002163 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5732
PTGER3GeneProductENSBTAG00000019230 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5733
PTGER4GeneProductENSBTAG00000014972 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5734
PTGIRGeneProductENSBTAG00000014585 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5739
PTGISGeneProductENSBTAG00000017537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5740
PTGS1GeneProductENSBTAG00000006716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5742
ProgesteroneMetabolite57-83-0 (CAS)
Prostaglandin H2Metabolite745-65-3 (CAS)
S100A10GeneProductENSBTAG00000015147 (Ensembl)
  • PMID: 12962548 relationship with Annexin 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6281
S100A6GeneProduct
SCGB1A1GeneProductENSBTAG00000032918 (Ensembl)
  • PMID: 7615804, PMID: 3292559
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7356
TBXAS1GeneProductENSBTAG00000020225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6916
TXA2MetaboliteHMDB0001452 (HMDB)

Annotated Interactions

No annotated interactions
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