DNA Replication (Bos taurus)

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5. Leading/lagging strand synthesisOrc2Cdt1Orc complexMcm10Ubiquitinated Orc1Mcm5Cdc6Orc5Mcm7RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerMcm71. Assembly of the pre-replicative complexOrc23. DNA replication initiationDNAPolymerase AMcm6RFC38RFC140Mcm 4,6,7 trimer forms andassociates with the replication forkUbiquitinated Cdc6RNA PrimerMcm4Orc complexOrc2Mcm3Mcm2Orc4UbiquitinOrc complexPhosphorylated Orc1Orc1Mcm4Degraded by proteasome in cytosolDNA polymerase alpha:primase: origin complexOrc3Processive complexCdt1Orc5Mcm6Phosphorylated Cdc6p49RNA primer-DNA primerRFC37RFC Heteropentamer:RNA primer-DNA primerCdc62. Activation of the pre-replicative complexPrimasePre-replicative complexOrc34. Switching of origins to post-replicative stateOrc4Cdc6Gemininp70Orc5UbiquitinOrc complexOrc3Orc2Cdt1DNA polymerase alpha:primase: origin complexRFC40Mcm2p180Orc3Cdt1Orc complexRNA primer-DNA primerCdt1Pre-replicative complexRNA primer-DNA primer:origin duplex:PCNADegraded byproteasomein cytosolCdc6Originp58Mcm3Phosphorylation ofMcm 2-7 complexMcm5Mcm10RFC36GMNNRPA3ADPCDK2POLA1ORC4ORC3CTPPRIM1ATPdUTPADPORC2PCNAPOLD4GTPRFC1dATPUTPdGTPMCM2UBCATPMCM3CDC45LRPA4MCM10ORC5LCDT1PRIM2POLD2ORC1MCM7ATPCDC7L1ORC6RFC5DBF4MCM5POLD1POLERPA2RPA1RFC3ATPCDC6dCTPMCM4MCM6POLE2POLA2RFC2RFC4UBA52POLD3


Description

Studies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyces cerevisiae (budding yeast), is well understood, and has served as a model for studies of DNA replication initiation in multicellular eukaryotes, including humans. In general terms, the first step of initiation is the binding of the replication initiator to the origin of replication. The replicative helicase is then assembled onto the origin, usually by a helicase assembly factor. Either shortly before or shortly after helicase assembly, some local unwinding of the origin of replication occurs in a region rich in adenine and thymine bases (often termed a DNA unwinding element, DUE). The unwound region provides the substrate for primer synthesis and initiation of DNA replication. The best-defined eukaryotic origins are those of S. cerevisiae, which have well-conserved sequence elements for initiator binding, DNA unwinding and binding of accessory proteins. In multicellular eukaryotes, unlike S. cerevisiae, these loci appear not to be defined by the presence of a DNA sequence motif. Indeed, choice of replication origins in a multicellular eukaryote may vary with developmental stage and tissue type. In cell-free models of metazoan DNA replication, such as the one provided by Xenopus egg extracts, there are only limited DNA sequence specificity requirements for replication initiation. Source description: http://www.reactome.org/content/detail/69306.

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(79981) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
107078view14:16, 17 September 2019MaintBotChEBI identifier normalization
96303view18:26, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
89896view13:12, 6 October 2016MkutmonModified description
89894view13:10, 6 October 2016MkutmonModified description
89892view13:08, 6 October 2016MkutmonReverted to version '15:28, 30 June 2015' by Mkutmon
89890view13:08, 6 October 2016MkutmonModified description
80850view15:28, 30 June 2015Mkutmonhomology conversion
71396view19:00, 17 October 2013MaintBotAutomated update of data sources
67167view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
63318view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
40499view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35220view15:52, 11 February 2010Thomasadded literature
35208view15:43, 11 February 2010ThomasModified description
35206view15:42, 11 February 2010ThomasModified description
33743view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33627view10:04, 1 December 2009MaintBotRemoved group label
31638view22:25, 13 August 2009MaintBotFixed text labels
30552view22:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDC45LGeneProductENSBTAG00000004286 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC6GeneProductENSBTAG00000010384 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990
CDC7L1GeneProductENSBTAG00000016307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDT1GeneProductENSBTAG00000000638 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81620
CTPMetabolite65-47-4 (CAS)
DBF4GeneProductENSBTAG00000014711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926
GMNNGeneProductENSBTAG00000017329 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51053
GTPMetabolite2564-35-4 (CAS)
MCM10GeneProductENSBTAG00000016406 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388
MCM2GeneProductENSBTAG00000014380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171
MCM3GeneProductENSBTAG00000010721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000017021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM5GeneProductENSBTAG00000015595 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174
MCM6GeneProductENSBTAG00000015172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
ORC1GeneProductENSBTAG00000002719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
ORC2GeneProductENSBTAG00000031473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999
ORC3GeneProductENSBTAG00000016969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595
ORC4GeneProductENSBTAG00000015291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000
ORC5LGeneProductENSBTAG00000040058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001
ORC6GeneProductENSBTAG00000001872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594
PCNAGeneProductENSBTAG00000006065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
POLA1GeneProductENSBTAG00000008170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5422
POLA2GeneProductENSBTAG00000011455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23649
POLD1GeneProductENSBTAG00000011083 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5424
POLD2GeneProductENSBTAG00000012241 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5425
POLD3GeneProductENSBTAG00000016869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10714
POLD4GeneProductENSBTAG00000017951 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57804
POLE2GeneProductENSBTAG00000004931 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5427
POLEGeneProductENSBTAG00000000590 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5426
PRIM1GeneProductENSBTAG00000044000 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5557
PRIM2GeneProductENSBTAG00000007937 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146143
RFC1GeneProductENSBTAG00000014515 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5981
RFC2GeneProductENSBTAG00000018589 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5982
RFC3GeneProductENSBTAG00000010787 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5983
RFC4GeneProductENSBTAG00000014727 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5984
RFC5GeneProductENSBTAG00000007137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5985
RPA1GeneProductENSBTAG00000009711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6117
RPA2GeneProductENSBTAG00000006225 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6118
RPA3GeneProductENSBTAG00000013168 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6119
RPA4GeneProduct
UBA52GeneProductENSBTAG00000007737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7311
UBCGeneProduct
UTPMetaboliteCHEBI:15713 (ChEBI)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)
dUTPMetaboliteCHEBI:17625 (ChEBI)

Annotated Interactions

No annotated interactions
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