EGF/EGFR Signaling Pathway (Bos taurus)

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SHC1DAGIP3Internalization, degradation and recycling of EGFRPIP2PIP3PIP2NUCYCYCa2+EGF/EGFR Signaling PathwayNURegulation of actin polymerizationERK1/2, ERK5, p38MAPK, JNK and NFKB mediated gene expressionCYReleaseNUNFKB pathwayNUCYNURPS6KA1PTPRRCDC42PCNAPRKCIVAV2MAP3K4MAP3K2NEDD4JAK1LIMK2RASA1REPS2SHC1SH3GL2INPPL1NEDD8PDPK1GJA1MYBL2FOSSTAT3STMN1PRKCBIQGAP1RPS6KA3HRASSTAM2JUNDCSKMAP2K5ERBB2CRKLRPS6KA5MAPK8GRIM19SP1PTPN12RAB5APLSCR2RAF1CREB1PLSCR2EPN1PIK3R2TWIST1DOK2ROCK1ITCHEGFARHGEF1RALABCAR1PTK2BNCK1PEBP1NOS3IQSEC1PTENUSP8MAP2K2PIK3C2BRIN1RALBP1PRKCAMTORCRKSH3GL3TNK2EGFRPTPN5SOS1PIK3R1NCOA3ELK1KRASRICTORJAK2PRKCZSTAT1EPS8MAP2K1RALGDSFOSBVAV3SOS2RPS6KB1AKT1USP6NLCAV2PLD2GRB10RAP1AARF6MAPK1PRKCSHCAMK2ASPRY2PTPN11BRAFMAP3K1DNM1MAPK14PTK6NCK2VAV1STAMSH3KBP1EPS15AP2S1RPS6KA2AP2B1PLCE1E2F1GRB2RALBSH2D2ASTAT5AAP2A1EGFRSRCMAPK4RAC1ATF1CAV1MAPK9MEF2DGAB1ERRFI1FOXO4STAMBPEGFRCOIIPLCG1MAP4K1EPS15L1MAP3K3INPP5DAURKASYNJ1ABL1STXBP1ELK4GAB2HGSMAPK7JUNSTAT5BPIAS3EIF4EBP1ABI1PRKCDATXN2FOXO1ASAP1PPPPUbPPPPGTPPPPPGTPPPPPUbpPPPPPPPPPPPPPPPPPPPGTPPGTPPPPPPPGTPGTPPPPGTPPPGTPPPEGFREGFRCBLBCBLCBLCSRCPGRB2PSOS1RALBP1CBLBCBLPCBLCPRKCSHPAK1PSTAT3PSTAT1STAT5BPSTAT5APPCFL1PTK2PEGFAP2M1PIAS3MEF2ASRCPXNEndosome/Multivesicular bodies/LysozomeHRASGTPVAV2PSP1PEPS8MEF2CRPS6KA3MAPK4MAPK1MAPK9MAPK8PPMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYProtein - protein dissociationReceptorProteinEnzyme ComplexmRNAProteinProteinLigandSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule


Description

Epidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases

which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Several ligands such as epidermal growth factor, transforming growth factor-alpha, epigen, amphiregulin, betacellulin, heparin-binding EGF and epiregulin are known to specifically bind to EGFR. Epidermal growth factor (EGF) is one of the high affinity ligands of EGFR. EGF/EGFR system induces growth, differentiation, migration, adhesion and cell survival through various inter-acting signaling pathways. The binding of EGF to the extracellular domain of EGFR induces the dimerization, activation of intrinsic kinase activity and subsequent autophosphorylation of EGFR at multiple residues in the cytoplasmic region such as Tyr 1092, Tyr 1172, Tyr 1197, Tyr 1110, Tyr 1016). Activated EGFR recruits various cytoplasmic proteins which transduce and regulate the EGFR function. The proteins recruited to active EGFR include many Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain containing proteins which binds to the tyrosine phosphorylated residues in EGFR, enzymes which act on EGFR and also various EGFR substrates. One of the adapter proteins, GRB2, binds to the phosphotyrosine residue at 1068 and recruits SOS to the membrane. SOS activates GDP/GTP exchange which recruits RAF to the membrane. RAF phosphorylates MEKs, which then activates the extracellular signal regulated kinase (ERK). ERK activates a number of transcriptional regulators to induce cell growth and proliferation. GRB2 or other adaptor proteins such as GABs recruits PI3Ks, another major mediator of EGFR signaling. PI3Ks convert Phosphatidylinositol-4,5-bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 binds to PH domain of AKT and recruits it to plasma membrane. PDK1 phosphorylates AKT which in turn regulate the activity of various proteins that mediate cell survival. EGFR also activate phospholipase C which hydrolyses PIP2 to generate Inositol trisphosphate (IP3) and 1,2-Diacylglycerol (DAG). IP3 induces the release of Ca2+ from endoplasmic reticulum to activate calcium regulated pathways. DAG activates protein kinase C pathway. One of the signaling modules regulated by PKC in EGFR pathway is the NFKB module. The protein SRC is a key player in the activation of various pathways such as RAS, PLC and also the STAT proteins in various cells. Other signaling modules activated by EGFR include the FAK, JNK, p38MAPK and ERK5 modules. EGFR induces the JNK pathway through the activation of G proteins such as RAC and CDC42 which recruits JNK kinases as well as regulate the actin polymerization. EGFR also translocates from the plasma membrane to other cellular compartments including nucleus where it directly regulate the expression of several genes in cooperation with other transcriptional regulators such as STATs, PCNA and E2F family of proteins. Being a growth, differentiation and cell survival factor; mutations and overexpression of EGFR and also the defective regulation of its signal transduction pathways has been established to be associated with oncogenesis. Thus, EGFR and its signaling components are promising targets for effective therapy for various cancers. There are several proteins which have been reported to regulate the EGFR signaling such as CBL, CSK, PKC and PTEN which promotes endocytosis or reduction in the EGFR activity or its signaling mediators. The major endocytic pathway of EGFR is established to be the clathrin coated pits which delivers them to endosomes. The endosomal pathway recycles the membraneous form of EGFR or form multivesicular bodies (MVB) and fuse with lysosomes for to the degradation pathway.


Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(79266) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
80732view15:23, 30 June 2015Mkutmonhomology conversion
67181view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63391view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
40564view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35721view23:29, 12 February 2010AlexanderPico
35435view11:32, 12 February 2010MichielAdded ref
33802view00:17, 9 December 2009MaintBotAutomatic update of empty xrefs
30547view21:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI1ProteinENSBTAG00000005136 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10006
ABL1ProteinENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AP2A1ProteinENSBTAG00000019180 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:160
AP2B1ProteinENSBTAG00000020316 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:163
AP2M1ProteinENSBTAG00000020106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1173
AP2S1ProteinENSBTAG00000010584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1175
ARF6ProteinENSBTAG00000045980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:382
ARHGEF1ProteinENSBTAG00000018912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138
ASAP1ProteinENSBTAG00000003185 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50807
ATF1ProteinENSBTAG00000018131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
ATXN2ProteinENSBTAG00000022069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6311
AURKARnaENSBTAG00000013009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6790
BCAR1ProteinENSBTAG00000012002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
BRAFProteinENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CAMK2AProteinENSBTAG00000020087 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
CAV1ProteinENSBTAG00000017869 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
CAV2ProteinENSBTAG00000045584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
CBLBProteinENSBTAG00000013057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:868
CBLCProteinENSBTAG00000009494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23624
CBLProteinENSBTAG00000006817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867
CDC42ProteinENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CFL1ProteinENSBTAG00000021455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1072
COIIGeneProductENSBTAG00000043556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513
CREB1ProteinENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CRKProteinENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CRKLProteinENSBTAG00000045548 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
CSKProteinENSBTAG00000021424 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1445
DNM1ProteinENSBTAG00000011307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1759
DOK2ProteinENSBTAG00000003341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9046
E2F1ProteinENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
EGFProtein
EGFRProteinENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
EIF4EBP1ProteinENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
ELK1ProteinENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4ProteinENSBTAG00000004953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
EPN1ProteinENSBTAG00000046996 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29924
EPS15ProteinENSBTAG00000005542 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2060
EPS15L1ProteinENSBTAG00000009990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58513
EPS8ProteinENSBTAG00000000369 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2059
ERBB2ProteinENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
ERRFI1ProteinENSBTAG00000006609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54206
FOSBProteinENSBTAG00000008182 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2354
FOSProteinENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
FOXO1ProteinENSBTAG00000044105 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2308
FOXO4ProteinENSBTAG00000004879 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4303
GAB1ProteinENSBTAG00000002813 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549
GAB2Protein
GJA1ProteinENSBTAG00000001835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2697
GRB10ProteinENSBTAG00000017086 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2887
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
GRIM19Protein
HGSProteinENSBTAG00000000411 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9146
HRASProteinENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
INPP5DProteinENSBTAG00000020173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3635
INPPL1ProteinENSBTAG00000019167 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3636
IQGAP1ProteinENSBTAG00000013060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8826
IQSEC1ProteinENSBTAG00000003237 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9922
ITCHProteinENSBTAG00000000308 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83737
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK2ProteinENSBTAG00000012047 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JUNDProtein
JUNProteinENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KRASProtein
LIMK2ProteinENSBTAG00000010662 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3985
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K5ProteinENSBTAG00000000218 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP3K1ProteinENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAP3K2ProteinENSBTAG00000004216 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10746
MAP3K3ProteinENSBTAG00000008151 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4215
MAP3K4ProteinENSBTAG00000020079 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4216
MAP4K1ProteinENSBTAG00000021145 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK4ProteinENSBTAG00000009907 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK7ProteinENSBTAG00000001014 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9ProteinENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MEF2AProteinENSBTAG00000010649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
MEF2CProteinENSBTAG00000020701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
MEF2DProteinENSBTAG00000046545 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4209
MTORProteinENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MYBL2RnaENSBTAG00000007783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4605
NCK1ProteinENSBTAG00000018427 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
NCK2ProteinENSBTAG00000015205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8440
NCOA3ProteinENSBTAG00000007489 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8202
NEDD4ProteinENSBTAG00000013793 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4734
NEDD8ProteinENSBTAG00000021446 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4738
NOS3GeneProductENSBTAG00000017680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
PAK1ProteinENSBTAG00000010191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PCNAProteinENSBTAG00000006065 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
PDPK1ProteinENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PEBP1ProteinENSBTAG00000018115 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5037
PIAS3ProteinENSBTAG00000021634 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401
PIK3C2BProteinENSBTAG00000024633 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5287
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PLCE1ProteinENSBTAG00000018966 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51196
PLCG1ProteinENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
PLD2ProteinENSBTAG00000013392 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5338
PLSCR2ProteinENSBTAG00000022227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5359
PRKCAProteinENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBProteinENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCDProteinENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCIProteinENSBTAG00000001403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCSHProteinENSBTAG00000017490 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5337
PRKCZProteinENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PTENProteinENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
PTK2BProteinENSBTAG00000005958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
PTK2ProteinENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
PTK6ProteinENSBTAG00000044091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5753
PTPN11ProteinENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
PTPN12ProteinENSBTAG00000003825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5782
PTPN5ProteinENSBTAG00000020257 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84867
PTPRRProteinENSBTAG00000015311 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5801
PXNProtein
RAB5AProteinENSBTAG00000046385 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5868
RAC1ProteinENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RALAProteinENSBTAG00000006661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5898
RALBProteinENSBTAG00000032021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5899
RALBP1ProteinENSBTAG00000021250 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10928
RALGDSProteinENSBTAG00000004194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5900
RAP1AProteinENSBTAG00000014710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RASA1ProteinENSBTAG00000009565 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
REPS2ProteinENSBTAG00000031261 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9185
RICTORProteinENSBTAG00000006697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:253260
RIN1ProteinENSBTAG00000017681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9610
ROCK1ProteinENSBTAG00000008403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
RPS6KA1ProteinENSBTAG00000014447 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
RPS6KA2ProteinENSBTAG00000021741 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6196
RPS6KA3ProteinENSBTAG00000017639 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6197
RPS6KA5ProteinENSBTAG00000010906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
RPS6KB1ProteinENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
SH2D2AProteinENSBTAG00000024470 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9047
SH3GL2ProteinENSBTAG00000014103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6456
SH3GL3ProteinENSBTAG00000018004 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6457
SH3KBP1ProteinENSBTAG00000003727 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:30011
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SOS2ProteinENSBTAG00000005550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6655
SP1ProteinENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
SPRY2ProteinENSBTAG00000001774 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10253
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAM2ProteinENSBTAG00000001887 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10254
STAMBPProteinENSBTAG00000009600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10617
STAMProteinENSBTAG00000002658 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8027
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BProteinENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
STMN1ProteinENSBTAG00000026505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3925
STXBP1ProteinENSBTAG00000003525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6812
SYNJ1ProteinENSBTAG00000003063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8867
TNK2ProteinENSBTAG00000021364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10188
TWIST1RnaENSBTAG00000046922 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7291
USP6NLProteinENSBTAG00000019488 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9712
USP8ProteinENSBTAG00000011916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9101
VAV1ProteinENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409
VAV2ProteinENSBTAG00000004511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7410
VAV3ProteinENSBTAG00000031575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10451

Annotated Interactions

No annotated interactions
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