IL-9 Signaling Pathway (Bos taurus)

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STAT1STAT5BMAPK3ProteinIL-9 Signaling PathwayCYCYCYNUNUNUGRB2STAT3PIK3R2PSTAT1STAT5ASTAT1PSTAT1PSTAT5BPCDK9MAPK1IL9PJAK3STAT1PSTAT5BIL2RGMAP2K2PIK3R1JAK1STAT3PSTAT5BPIL9RPMAP2K1PSTAT1STAT1PmRNALigandProteinEnzyme complexReceptorInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


Description

IL-9 is a multifunctional cytokine, belong to a family of cytokines. IL-9 was initially reported as a T cell growth factor in mice. It is now known to target multiple cell types. It plays an important role in the expansion and recruitment of mast cells in response to intestinal nematode infection or during autoimmune encephalomyelitis. It is also known to act on various cell types known to be involved in asthma including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells. IL 9 can promote the expression of TGF-beta in lipopolysaccharide induced monocytes and macrophages. IL-9 is also known to play important roles in conditions including airway inflammation, EAE and parasitic infections. Mitogen-activated protein kinase pathway is activated transiently by IL-9, which in turn leads to the growth stimulation of hematopoietic cell lines. IL-9 signals through the heterodimeric receptor composed of a specific chain (IL-9R) and a gamma chain (IL2RG), which is shared between IL-2, IL-4, IL-7, IL15 and IL-21. The IL-9R and IL-2RG associates with JAK1 and JAK3 respectively. Receptor engagement results in JAK1- JAK3 cross phosphorylation and activation of the JAK proteins which leads to the activation of Signal transducer and activator of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in the activation of MEK/ERK signaling cascade.

Please access this pathway at NetSlim database.

If you use this pathway, you must cite following paper:

Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP22(79264) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
80917view15:31, 30 June 2015Mkutmonhomology conversion
63449view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40583view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
33821view00:24, 9 December 2009MaintBotAutomatic update of empty xrefs
31633view22:23, 13 August 2009MaintBotFixed text labels
30543view21:57, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CDK9ProteinENSBTAG00000004695 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1025
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
IL2RGProteinENSBTAG00000007626 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3561
IL9ProteinENSBTAG00000018290 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3578
IL9RProteinENSBTAG00000007558 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3581
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
JAK3ProteinENSBTAG00000020904 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3718
MAP2K1ProteinENSBTAG00000033983 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3ProteinENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2ProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AProteinENSBTAG00000009496 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BProteinENSBTAG00000010125 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777

Annotated Interactions

No annotated interactions
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