Wnt Signaling Pathway (Drosophila melanogaster)

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1WntMicrotubleGSK3B-cateninTCF/LEFHedghogPP2cCipanFuCiSu(fu)SggHhDppPP2ADkkSlmbPtcDshHhBTrCPPKAAPCFRPCos2CBPNklWif-1Su(fu)WgSmogbpCos2AmWgCK1,2PtcFuFz2HhAxinCerDally


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

GenMAPP notes 
http://www.genome.ad.jp/kegg/pathway/dme/dme04310.html
GenMAPP remarks 
Adapted from KEGG (see notes)

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
95440view06:11, 15 December 2017MaintBotfixed xref
95439view06:02, 15 December 2017MaintBotfixed xref
95438view05:55, 15 December 2017MaintBotfixed xref
79653view11:50, 1 April 2015EgonwRemoved database names when no identifier was given (Flybase).
79497view15:28, 23 March 2015EgonwRemoved database source when no identifier was given.
79432view02:43, 22 March 2015Khanspersupdating datasources
79371view19:41, 21 March 2015Khanspersupdate schema
79370view19:40, 21 March 2015KhanspersReverted to version '11:59, 26 June 2013' by Khanspers
71519view19:22, 17 October 2013MaintBotAutomated update of data sources
68726view22:00, 6 July 2013MaintBotUpdated to 2013 gpml schema
67755view11:59, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
62827view04:33, 3 May 2013MaintBotUpdated UniProt data source
40902view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
35117view13:22, 11 February 2010Thomasadded literature
35113view13:18, 11 February 2010ThomasModified description
34159view21:09, 9 December 2009MaintBotAutomatic update of empty xrefs
20885view11:30, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:Wnt-signaling pathway KEGG]] moved to [[Pathway:WP97]]: Moved to stable identifier
8531view14:02, 7 January 2008MaintBotAdded to category $category
8529view14:02, 7 January 2008A.J.CaroloUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProductQ9Y1T2 (Uniprot-TrEMBL)
AmGeneProductP18824 (Uniprot-TrEMBL)
AxinGeneProductQ9V407 (Uniprot-TrEMBL)
BTrCPGeneProduct
CBPGeneProductO96676 (Uniprot-TrEMBL)
CK1,2GeneProductQ9V462 (Uniprot-TrEMBL)
CerGeneProduct37229 (Entrez Gene)
CiGeneProductP19538 (Uniprot-TrEMBL)
Cos2GeneProductQ9V4K0 (Uniprot-TrEMBL)
DallyGeneProductQ24114 (Uniprot-TrEMBL)
DkkGeneProduct
DppGeneProductQ9VQC6 (Uniprot-TrEMBL)
DshGeneProductP51140 (Uniprot-TrEMBL)
FRPGeneProduct
FuGeneProductP23647 (Uniprot-TrEMBL)
Fz2GeneProductQ9VVX2 (Uniprot-TrEMBL)
HhGeneProductQ02936 (Uniprot-TrEMBL)
NklGeneProduct
PKAGeneProductFBgn0000273 (FlyBase)
PP2AGeneProductFBgn0042693 (FlyBase)
PP2cGeneProductFBgn0022768 (FlyBase)
PtcGeneProductP18502 (Uniprot-TrEMBL)
SggGeneProductP18431 (Uniprot-TrEMBL)
SlmbGeneProductQ9VDE3 (Uniprot-TrEMBL)
SmoGeneProductP91682 (Uniprot-TrEMBL)
Su(fu)GeneProductQ9VG38 (Uniprot-TrEMBL)
WgGeneProductP09615 (Uniprot-TrEMBL)
Wif-1GeneProduct
gbpGeneProductQ24055 (Uniprot-TrEMBL)
panGeneProductFBgn0085432 (FlyBase)

Annotated Interactions

No annotated interactions
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