Integrin-mediated cell adhesion (Pan troglodytes)

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 70% conversion rate.

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Ontology Terms



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia


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71672view19:41, 17 October 2013MaintBotAutomated update of data sources
69265view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67405view10:57, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62740view03:34, 2 May 2013MaintBotUpdated UniProt data source
41573view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35602view15:46, 12 February 2010ThomasModified description
35595view15:43, 12 February 2010Thomasadded literature
34301view22:05, 9 December 2009MaintBotAutomatic update of empty xrefs
33600view09:56, 1 December 2009MaintBotRemoved group label
30520view21:49, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2GeneProduct456035 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
AKT3GeneProduct735718 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ARAFGeneProductARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7GeneProduct452673 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1GeneProduct454246 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BRAFGeneProduct463781 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProductCAPN10; calpain 10 [EC:
CAPN11GeneProduct462727 (Entrez Gene) CAPN11; calpain 11 [EC:]
CAPN1GeneProduct451317 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
CAPN2GeneProductCAPN2; calpain 2 (m/II) large subunit [EC:]
CAPN3GeneProduct453363 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
CAPN5GeneProduct451438 (Entrez Gene) CAPN5; calpain
CAPN6GeneProduct465810 (Entrez Gene) CAPN6; calpain 6 [EC:]
CAPN7GeneProduct460202 (Entrez Gene) CAPN7; calpain 7 [EC:
CAPN9GeneProduct457812 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
CAPNS1GeneProductCAPNS1; calpain small subunit 1 [EC:]
CAV1GeneProduct463670 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct494183 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct738786 (Entrez Gene) CAV3; caveolin 3
CDC42GeneProduct456609 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRKGeneProduct747142 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSKGeneProduct453745 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
DOCK1GeneProduct739420 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FYNGeneProduct462944 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
GIT2GeneProduct452227 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
GRB2GeneProduct737245 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
HRASGeneProduct466302 (Entrez Gene)
ILKGeneProduct748941 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct457982 (Entrez Gene)
ITGA11GeneProduct453537 (Entrez Gene)
ITGA1GeneProduct461880 (Entrez Gene)
ITGA2GeneProduct471550 (Entrez Gene)
ITGA2BGeneProduct454730 (Entrez Gene)
ITGA3GeneProduct455111 (Entrez Gene)
ITGA4GeneProduct470596 (Entrez Gene)
ITGA5GeneProduct451958 (Entrez Gene)
ITGA6GeneProduct459742 (Entrez Gene)
ITGA7GeneProduct451967 (Entrez Gene)
ITGA8GeneProduct450323 (Entrez Gene)
ITGA9GeneProduct470789 (Entrez Gene)
ITGADGeneProduct468103 (Entrez Gene)
ITGALGeneProduct454045 (Entrez Gene)
ITGAMGeneProduct454069 (Entrez Gene)
ITGAVGeneProduct459807 (Entrez Gene)
ITGAXGeneProduct454070 (Entrez Gene)
ITGB1GeneProduct450396 (Entrez Gene)
ITGB2GeneProduct458607 (Entrez Gene)
ITGB3GeneProduct468295 (Entrez Gene)
ITGB4GeneProduct454887 (Entrez Gene)
ITGB5GeneProduct460646 (Entrez Gene)
ITGB6GeneProduct459683 (Entrez Gene)
ITGB7GeneProduct451934 (Entrez Gene)
ITGB8GeneProduct463282 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2GeneProduct456390 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3GeneProduct454515 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5GeneProduct453532 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6GeneProduct468310 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10GeneProduct461358 (Entrez Gene)
MAPK12GeneProductMAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1GeneProduct458680 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4GeneProductMAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6GeneProduct453439 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7GeneProduct454499 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2GeneProduct742591 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
PAK1GeneProduct451439 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2GeneProduct460965 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3GeneProduct450118 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4GeneProductPAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6GeneProductPAK6; p21(CDKN1A)-activated kinase
PDPK1GeneProductPDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
PIK3R2GeneProduct455855 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2GeneProduct464422 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
PXNGeneProduct452303 (Entrez Gene) PXN; paxillin
RAC1GeneProductRAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2GeneProduct742575 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3GeneProductRAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1GeneProduct460182 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct469408 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct452065 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct464812 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHOGeneProduct460685 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1GeneProduct455326 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2GeneProduct470307 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1GeneProduct461897 (Entrez Gene) SEPP1; selenoprotein P plasma
SHC1GeneProduct457351 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct450176 (Entrez Gene) SHC3; neuronal Sh
SORBS1GeneProduct450628 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
SOS1GeneProduct459171 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SRCGeneProduct458229 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
TLN1GeneProductTLN1; talin 1
TNS1GeneProduct459934 (Entrez Gene) TNS; tensi
VASPGeneProduct468919 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV2GeneProductVAV2; vav 2 oncogene
VAV3GeneProduct457076 (Entrez Gene) VAV3; vav 3 oncogene
VCLGeneProduct450531 (Entrez Gene) VCL; vinculin
ZYXGeneProductZYX; zyxin

Annotated Interactions

No annotated interactions
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