Id Signaling Pathway (Pan troglodytes)

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PhosphorylationRecruitmentActivationProteolytic cleavageID Gene RegulationGlycosylationDDPNUEnzyme complexNucleusCytoplasmENDTranslocationAcetylationDephosphorylationProteins in a complex interactionAutophosphorylationGolgi apparatusMitochondriaMolecule in the PathwayControlMethylationPMExtracellularDDeubiquitinationLigandUbiquitinationERMolecular associationEndosomeDSumoylationPalmitoylationInhibitionGOReceptorDesumoylationPCY(Protein-protein interaction)Reaction through unknown mechanisms/moleculesPAccession Number: NetPath 5; cellmap:5DeacetylationMTECCY -> NUDemethylationEndoplasmic reticulumPlasma membraneMYF5TERTATF3PAX8CD40LGSMAD4SMAD3ID2SMAD5NFKB1ELK4BMPR2ID1ELK3PI3KRB1MYOD1ID2ID4VEGFEGFCCNE1RASMYF6MYOGCTNNB1SMAD4IRS1PSMD4RBL2MSCKDRBMP6PAX5SMAD1IFI16SMAD1IGF1MAPKTGIF1IGF1RID3TCF12BMP2PAX2ERKCCNA2SMAD5ATF3ACVRL1TCRSREBF1TCF7L2ELK1NGFSMAD3LCKCDK2RBL1TCF3HES1Gene SymbolFLT1RELA


Description

Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_5

Comments

GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 71% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69296view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67362view10:42, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
41606view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
35750view23:58, 12 February 2010AlexanderPico
34335view22:16, 9 December 2009MaintBotAutomatic update of empty xrefs
31608view22:12, 13 August 2009MaintBotFixed text labels
30503view21:43, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVRL1GeneProduct451910 (Entrez Gene)
ATF3GeneProduct469143 (Entrez Gene)
BMP2GeneProduct458090 (Entrez Gene)
BMP6GeneProduct471851 (Entrez Gene)
BMPR2GeneProduct459885 (Entrez Gene)
CCNA2GeneProduct461467 (Entrez Gene)
CCNE1GeneProduct455914 (Entrez Gene)
CD40LGGeneProduct473802 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
EGFGeneProduct461435 (Entrez Gene)
ELK1GeneProduct
ELK3GeneProduct467100 (Entrez Gene)
ELK4GeneProduct742304 (Entrez Gene)
ERKGeneProduct
FLT1GeneProduct452512 (Entrez Gene)
Gene SymbolGeneProduct
HES1GeneProduct460942 (Entrez Gene)
ID1GeneProduct469912 (Entrez Gene)
ID2GeneProduct
ID3GeneProduct745532 (Entrez Gene)
ID4GeneProduct747716 (Entrez Gene)
IFI16GeneProduct457424 (Entrez Gene)
IGF1GeneProduct741055 (Entrez Gene)
IGF1RGeneProduct453676 (Entrez Gene)
IRS1GeneProduct459985 (Entrez Gene)
KDRGeneProduct461315 (Entrez Gene)
LCKGeneProduct
MAPKGeneProduct
MSCGeneProduct472790 (Entrez Gene)
MYF5GeneProduct467081 (Entrez Gene)
MYF6GeneProduct745321 (Entrez Gene)
MYOD1GeneProduct451057 (Entrez Gene)
MYOGGeneProduct
NFKB1GeneProduct461406 (Entrez Gene)
NGFGeneProduct469423 (Entrez Gene)
PAX2GeneProduct744540 (Entrez Gene)
PAX5GeneProduct747452 (Entrez Gene)
PAX8GeneProduct459503 (Entrez Gene)
PI3KGeneProduct
PSMD4GeneProduct100192399 (Entrez Gene)
RASGeneProduct
RB1GeneProduct452715 (Entrez Gene)
RBL1GeneProduct735916 (Entrez Gene)
RBL2GeneProduct467978 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
SMAD1GeneProduct450142 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SMAD4GeneProduct468537 (Entrez Gene)
SMAD5GeneProduct745633 (Entrez Gene)
SREBF1GeneProduct454480 (Entrez Gene)
TCF12GeneProduct453466 (Entrez Gene)
TCF3GeneProduct
TCF7L2GeneProduct455432 (Entrez Gene)
TCRGeneProduct
TERTGeneProduct471443 (Entrez Gene)
TGIF1GeneProduct455312 (Entrez Gene)
VEGFGeneProduct

Annotated Interactions

No annotated interactions
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