G Protein Signaling Pathways (Pan troglodytes)

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1, 2CellResponseGiTranscriptionPhosphatase 2BProtein Kinase AG betacAMPPhosphodiesterasesG12/13AKAPsGsCytoskeletalChangesTranscriptionCellResponseG gammaGqProtein Kinase CAdenylate CyclasesPRKD3PRKCQGNAZRHOAADCY5PDE8BGNGT2DAGPRKCB1NRASCALM1ITPR1GNG13PRKCIPRKCHADCY3PRKAR1AGNAI1GNAO1GNAI3AKAP5GNA14AKAP2PDE7AAKAP9PRKAR2AIP3AKAP1PRKCEPDE1ASLC9A1AKAP8AKAP6ADCY8PLCB3GNB5GNASGNB2HRASGNG10ADCY6PDE1CGNA11PRKACGAKAP11PPP3CCADCY9GNG8PDE7BGNA12Ca2+PPP3CAGNALGNA15PRKAR1BPRKCGKCNJ3PPP3CCGNG11PDE4CGNAQAKAP7PDE4BGNG5PRKACAPDE4AGNGT1PDE1BPRKD1ADCY2AKAP13PDE8AGNAO1AKAP4PRKACBGNB3ADCY7AKAP12AKAP3GNG7GNG3PRKCDPDE4DAKAP10PRKAR2BGNAI2KRASPRKCZADCY1ADCY4GNAI1ARHGEF1GNG12PRKCAGNG4GNA13RRAScAMPGNB1


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC
  2. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106939view13:40, 17 September 2019MaintBotHMDB identifier normalization
71690view19:42, 17 October 2013MaintBotAutomated update of data sources
69302view18:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
67264view10:28, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
41612view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
35319view08:20, 12 February 2010ThomasModified description
35318view08:19, 12 February 2010Thomasadded literature
34341view22:18, 9 December 2009MaintBotAutomatic update of empty xrefs
33583view09:50, 1 December 2009MaintBotRemoved group label
31606view22:11, 13 August 2009MaintBotFixed text labels
30500view21:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY1GeneProduct463392 (Entrez Gene)
ADCY2GeneProduct461715 (Entrez Gene)
ADCY3GeneProduct459070 (Entrez Gene)
ADCY4GeneProduct452819 (Entrez Gene)
ADCY5GeneProduct470905 (Entrez Gene)
ADCY6GeneProduct451866 (Entrez Gene)
ADCY7GeneProduct473278 (Entrez Gene)
ADCY8GeneProduct464400 (Entrez Gene)
ADCY9GeneProduct453869 (Entrez Gene)
AKAP10GeneProduct468376 (Entrez Gene)
AKAP11GeneProduct740874 (Entrez Gene)
AKAP12GeneProduct
AKAP13GeneProduct743772 (Entrez Gene)
AKAP1GeneProduct455150 (Entrez Gene)
AKAP2GeneProduct
AKAP3GeneProduct466927 (Entrez Gene)
AKAP4GeneProduct465971 (Entrez Gene)
AKAP5GeneProduct467480 (Entrez Gene)
AKAP6GeneProduct452846 (Entrez Gene)
AKAP7GeneProduct462998 (Entrez Gene)
AKAP8GeneProduct748028 (Entrez Gene)
AKAP9GeneProduct472440 (Entrez Gene)
ARHGEF1GeneProduct
CALM1GeneProduct738819 (Entrez Gene)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteC00165 (KEGG Compound)
GNA11GeneProduct
GNA12GeneProduct463234 (Entrez Gene)
GNA13GeneProduct454827 (Entrez Gene)
GNA14GeneProduct472961 (Entrez Gene)
GNA15GeneProduct744860 (Entrez Gene)
GNAI1GeneProduct472425 (Entrez Gene)
GNAI2GeneProduct744773 (Entrez Gene)
GNAI3GeneProduct457093 (Entrez Gene)
GNALGeneProduct455285 (Entrez Gene)
GNAO1GeneProduct450173 (Entrez Gene)
GNAQGeneProduct
GNASGeneProduct469986 (Entrez Gene)
GNAZGeneProduct458693 (Entrez Gene)
GNB1GeneProduct469458 (Entrez Gene)
GNB2GeneProduct739897 (Entrez Gene)
GNB3GeneProduct
GNB5GeneProduct
GNG10GeneProduct746978 (Entrez Gene)
GNG11GeneProduct747185 (Entrez Gene)
GNG12GeneProduct
GNG13GeneProduct749882 (Entrez Gene)
GNG3GeneProduct740869 (Entrez Gene)
GNG4GeneProduct743331 (Entrez Gene)
GNG5GeneProduct740817 (Entrez Gene)
GNG7GeneProduct744391 (Entrez Gene)
GNG8GeneProduct745587 (Entrez Gene)
GNGT1GeneProduct747170 (Entrez Gene)
GNGT2GeneProduct749133 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
ITPR1GeneProduct460134 (Entrez Gene)
KCNJ3GeneProduct737029 (Entrez Gene)
KRASGeneProduct473387 (Entrez Gene)
NRASGeneProduct742713 (Entrez Gene)
PDE1AGeneProduct459797 (Entrez Gene)
PDE1BGeneProduct451962 (Entrez Gene)
PDE1CGeneProduct
PDE4AGeneProduct747380 (Entrez Gene)
PDE4BGeneProduct456921 (Entrez Gene)
PDE4CGeneProduct748644 (Entrez Gene)
PDE4DGeneProduct461860 (Entrez Gene)
PDE7AGeneProduct464213 (Entrez Gene)
PDE7BGeneProduct747541 (Entrez Gene)
PDE8AGeneProduct453612 (Entrez Gene)
PDE8BGeneProduct461796 (Entrez Gene)
PLCB3GeneProduct
PPP3CAGeneProduct461403 (Entrez Gene)
PPP3CCGeneProduct742406 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
PRKACBGeneProduct469367 (Entrez Gene)
PRKACGGeneProduct472944 (Entrez Gene)
PRKAR1AGeneProduct454845 (Entrez Gene)
PRKAR1BGeneProduct
PRKAR2AGeneProduct
PRKAR2BGeneProduct744011 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCEGeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCIGeneProduct450143 (Entrez Gene)
PRKCQGeneProduct450288 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene)
PRKD3GeneProduct459158 (Entrez Gene)
RHOAGeneProduct461014 (Entrez Gene)
RRASGeneProduct468955 (Entrez Gene)
SLC9A1GeneProduct456669 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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