Transforming Growth Factor (TGF) Beta Signaling Pathway (Pan troglodytes)

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1, 2Co-smadsRepressorsRsmadsAccessory receptors:Co-SmadsTGFbR-SmadsCofactorCofactorsligands:SMAD5SERPINE1INHBATGFBR1SMAD7FSTSTAT3TFE3EP300NFKB1ZEB2LIFSMAD1ZNF423SKILMAPK3CREBBPSTAT1TGFBR3IFNGSKISMAD4WNT1TGIF1SMAD2TGFBR2RUNX3TGFBR1JUNFOXH1MAPK9BMP4BMP4RUNX2SMAD6SPP1LTBP1EGFITGB6TNFLEF1SMAD1HRASENGCTNNB1TGFB1TGFBR2TGFB1SMAD3SMAD9BAMBITHBS1NOGSMAD2ZFYVE9FKBP1ATNFFOSJAK1


Description

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

Comments

GenMAPP remarks 
edited by: Nathan Salomonis
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 96% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC
  2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
87743view09:46, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87742view09:45, 25 July 2016MirellaKalafatiModified title
69239view18:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
41544view01:58, 2 March 2011MaintBotRemoved redundant pathway information and comments
34276view21:57, 9 December 2009MaintBotAutomatic update of empty xrefs
33582view09:50, 1 December 2009MaintBotRemoved group label
30499view21:42, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAMBIGeneProduct745034 (Entrez Gene)
BMP4GeneProduct452912 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
EGFGeneProduct461435 (Entrez Gene)
ENGGeneProduct741046 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
FKBP1AGeneProduct749347 (Entrez Gene)
FOSGeneProduct453047 (Entrez Gene)
FOXH1GeneProduct464468 (Entrez Gene)
FSTGeneProduct461879 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
IFNGGeneProduct449517 (Entrez Gene)
INHBAGeneProduct463371 (Entrez Gene)
ITGB6GeneProduct459683 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LEF1GeneProduct461425 (Entrez Gene)
LIFGeneProduct736309 (Entrez Gene)
LTBP1GeneProduct459143 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NOGGeneProduct468413 (Entrez Gene)
RUNX2GeneProduct472017 (Entrez Gene)
RUNX3GeneProduct456633 (Entrez Gene)
SERPINE1GeneProduct472467 (Entrez Gene)
SKIGeneProduct
SKILGeneProduct460844 (Entrez Gene)
SMAD1GeneProduct450142 (Entrez Gene)
SMAD2GeneProduct455407 (Entrez Gene)
SMAD3GeneProduct748161 (Entrez Gene)
SMAD4GeneProduct468537 (Entrez Gene)
SMAD5GeneProduct745633 (Entrez Gene)
SMAD6GeneProduct467711 (Entrez Gene)
SMAD7GeneProduct455411 (Entrez Gene)
SMAD9GeneProduct452539 (Entrez Gene)
SPP1GeneProduct461366 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
TFE3GeneProduct473871 (Entrez Gene)
TGFB1GeneProduct456060 (Entrez Gene)
TGFBR1GeneProduct472992 (Entrez Gene)
TGFBR2GeneProduct460243 (Entrez Gene)
TGFBR3GeneProduct457016 (Entrez Gene)
TGIF1GeneProduct455312 (Entrez Gene)
THBS1GeneProduct453319 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct744399 (Entrez Gene)
WNT1GeneProduct742674 (Entrez Gene)
ZEB2GeneProduct459644 (Entrez Gene)
ZFYVE9GeneProduct456855 (Entrez Gene)
ZNF423GeneProduct465158 (Entrez Gene)

Annotated Interactions

No annotated interactions
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