TNF-alpha NF-kB Signaling Pathway (Pan troglodytes)

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NucleusMitochondrionENPlasma membraneEndosomeDephosphorylationAccession Number: NetPath 9; cellmap:9LigandProteins in a complex interactionDeubiquitinationCY ->NUER(Protein-protein interaction)NUPhosphorylationDemethylationCY ->NUCYControlAcetylationRecruitmentReceptorDesumoylationMethylationEnzyme complexDeacetylationCY ->NUExtracellularTranslocationActivationAutophosphorylationCY ->NUReaction through unknown mechanisms/moleculesGolgi apparatusCytoplasmSumoylationGlycosylationPMEndoplasmic reticulumDECGOInhibitionMolecular associationPalmitoylationMTUbiquitinationMolecule in the pathwayCY ->NUProteolytic cleavageYWHAHTRAF6PPP2CANLRP4FKBP5KCNQ1GAB1TRAF4NR2C2MAP3K3IKBKAPUSP11TANKGeneUBE2D3PRELBAZI2PTK2RASAL2PEG3RELBIRC2POLR2LGeneCASP8AP2YWHAZKTN1TRAF1NSMAFBIRC2RIPK3DPF2YWHAQTRAF2PSMC1TNFRSF1BPEBP1POLR1ACYLDMCCRIPK1TNFRSF11APAPOLAUSP2CDC37CAPN3SMARCC1TRAIPCOMMD1POLR1ENFKBIERPL30YWHAGHSPB1PSMD12TRAF3RNF25PSMC2LOC737497RELAFBLCDC34MAP3K1KPNA3SKP1CSNK2A1PPP1R13LTIFAUNC5CLNR2C2HIST3H3POLR1BCSNK2A2CASP3RELPRKCZPRKACANFKB1TRAF4GTF2ITNFRSF1BRPS6KB1MAP3K8CSNK2BEIF4A3CHUKCAV1CFLARTRADDDDX3GeneTNFRSF1BCASP2MAP3K2PIAS3COPS3MAP3K14PSMB5TRAF5TNFRELAMAP2K5BCL3CASP7RIPK2POLR1CMTIF2NFKB1NFKBIARIPK1NKIRAS1TNFAIP3ACTL6ASMARCE1FANCD2PSMD6TNFAKT1TNFTRAF2TRADDZFAND5LOC464047GeneAKAP8NFKBIBBIRC3IKBKECD3EAPMAP3K7IP2LOC464259GSK3BTRAF1KPNA6SMARCA4CASP10TNFPSMD3RPL6TRPC4APPKN1DAPSUMO1G3BP2RELATNIP1TNFBIRC3PSMC3POLR2HPFDN2BAG4WDR68FAF1MARK2YWHABRPS13TNFRSF1APOLR1DRPL4MCM5KPNA2MAP3K7IP1IKBKGBTRCTNFRSF1AFADDTNFRSF1AHSP90AA1TRAF2ALPLPSMD7CASP8RNF216TNIP2AKT2IKBKBSMARCB1STAT1RPS11PMLHDAC6TBK1IKBKGPSMD1YWHAELOC462950NFKBIARELATBK1TNFRPL8TNFRSF8Gene SymbolMAP3K3PDCD2CUL1RELBCRADDNFKBIZMCM7TAB3CHUKGNB2L1CREBBPGLG1RPS6KA5BCL7APSMD13FBXW11NFKBIAIQGAP2SMARCC2FLNAPTPN11UBE2IUBE2D2TXLNALRPPRCSRCNFKB1NKIRAS2NFKB2


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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 81% conversion rate.

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History

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CompareRevisionActionTimeUserComment
87790view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87789view11:14, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69230view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
41534view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
34270view21:54, 9 December 2009MaintBotAutomatic update of empty xrefs
33581view09:49, 1 December 2009MaintBotRemoved group label
31605view22:10, 13 August 2009MaintBotFixed text labels
30498view21:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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