Hepatocyte growth factor receptor signaling (Pan troglodytes)

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1ActinExtracellularAP-1TranscriptionRAC1pathwayAnoikisTrancriptionCDC42pathwayRHOpathwayTranscriptionof Cox2AKT PathwayCytoplasmChanges in Cytoskeletonand Cell mobilityGAB1SRCPIK3CAMAP4K1CRKLITGA1PTK2MAPK1PAK1MetMAPK8MAP2K2PXNRAP1ARAF1SRCPTPN11ELK1STAT3FOSPTENITGB1PTK2BPTK2BPTK2CRKMAP2K1HGFHRASRASA1RAPGEF1MAPK3JUNPXNDOCK1GRB2RAP1BSOS1PPP


Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.


GenMAPP remarks 
Converted to human by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 86% conversion rate.

Quality Tags

Ontology Terms



  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia


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118823view08:55, 2 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118821view08:06, 2 June 2021DeSlOntology Term : 'hepatocyte' added !
118820view08:05, 2 June 2021DeSlConverted "P" to States
118819view08:04, 2 June 2021DeSlConverted ReceptorSquare to MIM binding with lit ref
118818view08:02, 2 June 2021DeSlConverted unconnected lines to Graphical lines
118817view08:02, 2 June 2021DeSlDeleted textLabel
118816view08:01, 2 June 2021DeSlAdded description from WP313
118037view11:49, 23 May 2021EweitzModified title
87670view08:55, 25 July 2016LindarieswijkOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
69306view18:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
41616view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
34344view22:19, 9 December 2009MaintBotAutomatic update of empty xrefs
33580view09:49, 1 December 2009MaintBotRemoved group label
31604view22:10, 13 August 2009MaintBotFixed text labels
30496view21:40, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
DOCK1GeneProduct739420 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
FOSGeneProduct453047 (Entrez Gene)
GAB1GeneProduct461516 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
HGFGeneProduct463503 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
ITGA1GeneProduct461880 (Entrez Gene)
ITGB1GeneProduct450396 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAP4K1GeneProduct748652 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MetGeneProduct463671 (Entrez Gene)
PAK1GeneProduct451439 (Entrez Gene)
PIK3CAGeneProduct460858 (Entrez Gene)
PTENGeneProduct466142 (Entrez Gene)
PTK2GeneProduct464422 (Entrez Gene)
PTK2BGeneProduct464073 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
PXNGeneProduct452303 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RAP1AGeneProduct469408 (Entrez Gene)
RAP1BGeneProduct452065 (Entrez Gene)
RAPGEF1GeneProduct464812 (Entrez Gene)
RASA1GeneProduct461762 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SRCGeneProduct458229 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)

Annotated Interactions

No annotated interactions
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