Statin Pathway PharmGKB (Pan troglodytes)

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1Liver cellLegendPlasmaRepressesCell MembraneTissuesActivatesTriglycerideFatty acidLRP1HMGCRLCATCholesterolCholesterol esterVLDLCholesterolAPOC3APOC1APOC2SOAT1LPLAPOEPLTPCYP7A1StatinCholic AcidCETPAPOA4Acetyl-CoAABCA1HDLLIPCIDLTRNPAPOA1PhospholipidDGAT1LDLRLDLSCARB1


Description

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP430(r29996) with a 78% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106936view13:40, 17 September 2019MaintBotHMDB identifier normalization
71660view19:40, 17 October 2013MaintBotAutomated update of data sources
69229view18:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67660view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
41532view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
35547view14:21, 12 February 2010Thomasadded literature, cosmetic change
34268view21:53, 9 December 2009MaintBotAutomatic update of empty xrefs
33576view09:48, 1 December 2009MaintBotRemoved group label
30490view21:38, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProduct464630 (Entrez Gene)
APOA1GeneProduct451564 (Entrez Gene)
APOA4GeneProduct466792 (Entrez Gene)
APOC1GeneProduct743864 (Entrez Gene)
APOC2GeneProduct744578 (Entrez Gene)
APOC3GeneProduct451563 (Entrez Gene)
APOEGeneProduct449586 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
CETPGeneProduct467982 (Entrez Gene)
CYP7A1GeneProduct464191 (Entrez Gene)
CholesterolMetabolite
Cholesterol esterMetaboliteC02530 (KEGG Compound)
Cholic AcidMetabolite
DGAT1GeneProduct464460 (Entrez Gene)
Fatty acidMetaboliteC00162 (KEGG Compound)
HDLMetaboliteC01834 (KEGG Compound)
HMGCRGeneProduct471516 (Entrez Gene)
IDLMetaboliteC01834 (KEGG Compound)
LCATGeneProduct743056 (Entrez Gene)
LDLMetaboliteC01834 (KEGG Compound)
LDLRGeneProduct455722 (Entrez Gene)
LIPCGeneProduct746925 (Entrez Gene)
LPLGeneProduct464031 (Entrez Gene)
LRP1GeneProduct452006 (Entrez Gene)
PLTPGeneProduct458291 (Entrez Gene)
PhospholipidMetaboliteC00865 (KEGG Compound)
SCARB1GeneProduct452359 (Entrez Gene)
SOAT1GeneProduct457553 (Entrez Gene)
StatinMetabolite
TRNPGeneProduct
TriglycerideMetaboliteC00422 (KEGG Compound)
VLDLMetaboliteC01834 (KEGG Compound)

Annotated Interactions

No annotated interactions
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