De Novo Biosynthesis of Pyrimidine Ribonucleotides (Saccharomyces cerevisiae)

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1H+acceptorH2Ocarbamoyl-phosphateUMPcarbamoyl-L-aspartateorotidine-5'-phosphateUTPH2OorotateCTPH2OL-aspartatereduced acceptorHCO3-dihydroorotateCO2UDPCDPURA10L-glutamineADPURA7ADPURA6URA1URA3YNK1URA5L-glutaminePRPP2 ATPURA8ATPURA2ATPphosphatephosphateATPURA2L-glutamateL-glutamateADPphosphateATPADPURA4pyrophosphate2 ADP


The ergosterol biosynthesis pathway is required for generation of a major constituent of the fungal plasma membrane, ergosterol (CITS: [Paltauf])(CITS: [8561481]). This pathway is fungal-specific; plasma membranes of other organisms are composed predominantly of other types of sterol. However, the pathway is not universally present in fungi; for example, Pneumocystis carinii plasma membranes lack ergosterol (CITS: [12531182]). In S. cerevisiae, some steps in the pathway are dispensible while others are essential for viability (CITS: [8277826]). The ergosterol biosynthesis pathway has been the subject of intensive investigation as a target of antifungal drugs (CITS: [11815273]). The major target of azole antifungal drugs is lanosterol 14-alpha demethylase, a member of the cytochrome P450 family known as Erg11 protein in many fungal species. Squalene epoxidase (Erg1p in S. cerevisiae) is the specific target of allylamine drugs such as terbinafine (CITS: [14638499]). Mutations in the genes encoding these enzymes and others in the pathway, as well as alterations in the expression levels of the pathway constituents, can lead to antifungal drug resistance (CITS: [11815273]). SOURCE: SGD pathways,


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  1. Wagner R, de Montigny J, de Wergifosse P, Souciet JL, Potier S; ''The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease.''; FEMS Microbiol Lett, 1998 PubMed


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102792view13:45, 24 January 2019EgonwBetter PubChem ID.
87230view14:47, 19 July 2016SusanOntology Term : 'de novo pyrimidine biosynthetic pathway' added !
87229view14:47, 19 July 2016SusanOntology Term : 'PW:0000861' removed !
87226view14:44, 19 July 2016SusanOntology Term : 'pyrimidine biosynthetic pathway' added !
71184view15:09, 11 October 2013EgonwFixed a metabolite label and added its identifier.
71183view15:01, 11 October 2013EgonwAdded missing metabolite identifiers.
71182view14:48, 11 October 2013EgonwPeriodical save, work in progress
70996view15:30, 22 September 2013EgonwAdded metabolite identifiers.
70248view21:36, 15 July 2013MaintBotupdated to 2013 schema
70053view06:01, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69729view08:03, 11 July 2013EgonwGive water HMDB ids.
54773view07:18, 9 December 2012EgonwReplaced multiple general nodes by Metabolite DataNode's.
54772view07:14, 9 December 2012EgonwConnecting dots
41915view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
36648view22:38, 9 April 2010MaintBotDescription and bibliography added from SGD
20875view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo Biosynthesis of Pyrimidine Ribonucleotides]] moved to [[Pathway:WP92]]: Moved to stable identifier
12686view07:58, 17 May 2008MaintBotautomated metabolite conversion
8690view14:06, 7 January 2008MaintBotAdded to category $category
8688view14:06, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
2 ADPMetabolite58-64-0 (CAS)
2 ATPMetabolite1927-31-7 (CAS)
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
CDPMetabolite63-38-7 (CAS)
CO2Metabolite274 (Chemspider)
CTPMetabolite6176 (PubChem-compound)
H+Metabolite1010 (Chemspider)
H2OMetaboliteHMDB02111 (HMDB)
HCO3-Metabolite749 (Chemspider)
L-aspartateMetaboliteCHEBI:29991 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
PRPPMetabolite97-55-2 (CAS)
UDPMetabolite1158 (PubChem-compound)
UMPMetabolite6030 (PubChem-compound)
URA10GeneProductS000004884 (SGD)
URA1GeneProductS000001699 (SGD)
URA2GeneProductS000003666 (SGD)
URA3GeneProductS000000747 (SGD)
URA4GeneProductS000004412 (SGD)
URA5GeneProductS000004574 (SGD)
URA6GeneProductS000001507 (SGD)
URA7GeneProductS000000135 (SGD)
URA8GeneProductS000003864 (SGD)
UTPMetabolite6133 (PubChem-compound)
YNK1GeneProductS000001550 (SGD)
carbamoyl-L-aspartateMetabolite279 (PubChem-compound)
carbamoyl-phosphateMetabolite3423467 (PubChem-compound)
dihydroorotateMetabolite1232048 (Chemspider)
orotateMetabolite942 (Chemspider)
orotidine-5'-phosphateMetabolite160617 (PubChem-compound)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions
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