IL-3 Signaling Pathway (Pan troglodytes)

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DMALigandMTActivationMAMAEndosomeDDesumoylationERPMDMACY->PMCytoplasmGlycosylationDAcetylationAccession Number: NetPath 15DemethylationPhosphorylationPalmitoylationGolgi apparatusDMitochondrionMethylation(Protein-protein interaction)InhibitionDGOTranslocationReaction through unknown mechanisms/moleculesDeacetylationDeubiquitinationDExtracellularDCY->NUCY->PMCY->NUAutophosphorylationControlProteolytic cleavageENNUMolecular AssociationMT->CYNucleusDDDDDDProteins in a complex interactionReceptorRecruitmentDDephosphorylationMolecule in the pathwaySumoylationMAEndoplasmic reticulumCYECCY->PMDDPlasma membraneUbiquitinationDDEnzyme complexMAKCNIP3VAV1ID1CISHCBLYWHAQPAK1GAB2PRKCARAP1AYWHABIL3BADGATA1GRB2PIK3CDGSK3ASRCPIK3R1MAPK3SHC1BADFESIL3PPP2CARPS6KB2PRKACAMAPK1BCL2STAT3HRASGATA2LYNFCER2MAPK8JAK1PTPN6HCKSELPPTPN11TYK2BCL2L11PIK3R2CREB1MMP2CSF2RBRAF1NFKB1IL3RAYWHAZSTAT1IL3MAPKAPK2MATKMAPK7SOS1SHC1CRKRARALCKIL3MAPK9MAPK14CRKLTNFRSF1BSTAT5ABAXRAC1MRASIL3RAGNB2L1CDC42FOXO1PTK2SOCS2SYKGAB1GSK3BPRKCB1SLC2A1BCL2L1JAK2RXRABIRC5CHEK1SPI1PXNTECMAP2K1PIK3CASOCS3PILRBATF1Gene SymbolRAPGEF1HSPB1STAT6ATF2NFKB1BMXINPP5DMAPK3DNM1KRASVCLRAC2MMP9AKT1FYNCSF2RBSLC2A1STAT5BPRKCA


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP286(r21281) with a 78% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
86928view13:04, 15 July 2016MkutmonOntology Term : 'interleukin-3 signaling pathway' added !
69255view18:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
41562view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35792view06:55, 13 February 2010MaintBotAdded description
34292view22:02, 9 December 2009MaintBotAutomatic update of empty xrefs
31597view22:07, 13 August 2009MaintBotFixed text labels
30482view21:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
ATF1GeneProduct452429 (Entrez Gene)
ATF2GeneProduct
BADGeneProduct
BAXGeneProduct747093 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
BCL2L11GeneProduct459487 (Entrez Gene)
BCL2L1GeneProduct458156 (Entrez Gene)
BIRC5GeneProduct455276 (Entrez Gene)
BMXGeneProduct
CBLGeneProduct451690 (Entrez Gene)
CDC42GeneProduct456609 (Entrez Gene)
CHEK1GeneProduct739836 (Entrez Gene)
CISHGeneProduct470819 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
CSF2RBGeneProduct458802 (Entrez Gene)
DNM1GeneProduct464766 (Entrez Gene)
FCER2GeneProduct
FESGeneProduct453654 (Entrez Gene)
FOXO1GeneProduct467352 (Entrez Gene)
FYNGeneProduct462944 (Entrez Gene)
GAB1GeneProduct461516 (Entrez Gene)
GAB2GeneProduct748918 (Entrez Gene)
GATA1GeneProduct738894 (Entrez Gene)
GATA2GeneProduct460672 (Entrez Gene)
GNB2L1GeneProduct462344 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GSK3AGeneProduct456071 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct458163 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
HSPB1GeneProduct463488 (Entrez Gene)
ID1GeneProduct469912 (Entrez Gene)
IL3GeneProduct471626 (Entrez Gene)
IL3RAGeneProduct751052 (Entrez Gene)
INPP5DGeneProduct470683 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
KCNIP3GeneProduct459401 (Entrez Gene)
KRASGeneProduct473387 (Entrez Gene)
LCKGeneProduct
LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK7GeneProduct454499 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MATKGeneProduct
MMP2GeneProduct454094 (Entrez Gene)
MMP9GeneProduct458294 (Entrez Gene)
MRASGeneProduct
NFKB1GeneProduct461406 (Entrez Gene)
PAK1GeneProduct451439 (Entrez Gene)
PIK3CAGeneProduct460858 (Entrez Gene)
PIK3CDGeneProduct457922 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PILRBGeneProduct
PPP2CAGeneProduct471633 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCB1GeneProduct
PTK2GeneProduct464422 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
PTPN6GeneProduct748032 (Entrez Gene)
PXNGeneProduct452303 (Entrez Gene)
RAC1GeneProduct
RAC2GeneProduct742575 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RAP1AGeneProduct469408 (Entrez Gene)
RAPGEF1GeneProduct464812 (Entrez Gene)
RARAGeneProduct454647 (Entrez Gene)
RPS6KB2GeneProduct746903 (Entrez Gene)
RXRAGeneProduct464834 (Entrez Gene)
SELPGeneProduct736004 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SLC2A1GeneProduct
SOCS2GeneProduct452127 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SPI1GeneProduct
SRCGeneProduct458229 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
STAT6GeneProduct452005 (Entrez Gene)
SYKGeneProduct464586 (Entrez Gene)
TECGeneProduct461343 (Entrez Gene)
TNFRSF1BGeneProduct457968 (Entrez Gene)
TYK2GeneProduct455703 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)
VCLGeneProduct450531 (Entrez Gene)
YWHABGeneProduct
YWHAQGeneProduct470302 (Entrez Gene)
YWHAZGeneProduct472830 (Entrez Gene)

Annotated Interactions

No annotated interactions
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