B Cell Receptor Signaling Pathway (Pan troglodytes)

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Proteins in a complex interactionDCY->NUCY->NUDInhibitionDDCY->PMGlycosylationTranslocationDemethylationDCytoplasmCY->MTMitochondriaExtracellularCY->PMDMTUbiquitinationERCY->PMENCY->NUCY->PMCY->PMCY->PMCY->PMPalmitoylationDSumoylationMACY->PM(Protein-protein interaction)AcetylationReaction through unknown mechanisms/moleculesPlasma membraneCY->PMCY->PMAccesion Number: NetPath 12ReceptorCY->NUPM->CYNU->CYActivationMT->CYEndoplasmic reticulumEndosomeAutophosphorylationCY->NUCY->PMDeubiquitinationCY->PMDNUMethylationMolecular associationNU->CYECEnzyme ComplexDCY->NUDephosphorylationProteolytic cleavageDesumoylationCY->PMComplexCY->NUDRecruitmentDCY->PMGOControlMolecule in the pathwayPM->CYGolgi apparatusDCY->PMPhosphorylationCY->PMDLigandPMDCY->PMARP2/3DCY->PMDeacetylationCYNucleusCY->NUDFOXO1HCLS1CDK6HNRNPKPIK3AP1DUSP6ITPR2DAPP1CBLRPS6KA1LYNLCKCCNE1PPP3R1RASA1ATF2PLEKHA1SHC1BLKMAP2K1PDPK1PIP4K2CPDK2LOC454721BCAR1RAPGEF1BTKPTPN6BRAFCD5GSK3ATECCD19GTF2ICD79APIP5K1CDUSP4GAB1CHUKBAXBTKPLEKHA2PLCG2IGHMCD22PRKCB1PRKCQPIK3R2PLEKHA1MAPK4FYNIKBKBVAV2JUNPIP4K2BBCL2L11PIP4K2BCASP7VAV1NFATC2GAB1PTK2PIP5K1BARPC2CTNNB1PIP5K1BCARD11INPP5DWASNFATC2ACTR3PPP3CAARPC4CTNNB1PRKCB1ARPC1BAKT1SH3BP2CD81PRKD1IKBKGGene SymbolNFKBIACD79ALYNPIK3AP1DAPP1DOK1PRKCDRHOACRKPTPRCNFATC3SYKPIK3R1BLNKGRB2PRKCEBCL6CHUKNFATC1INPP5DNEDD9MAPK3PILRBPLCG1CCND2HCLS1RELACHST15GSK3BFCGR2BITPR1BAXBANK1GTF2ICDK4GRB2PRKCECBLBPIP5K1ALOC466968LAT2BCL2RPS6CYCSCMTM3CD79BMAPK1CDK2DOK3PTPN6CRKCARD11ARPC3HCKRASGRP3ATP2B4PPP3CBRASGRP3LIME1RAP2ASOS2CDK7ELK1LAT2PIP4K2BCASP9PLEKHA2RAF1ACTR2BCL10CR2MAPK14IKBKBCCND3CD72SYKSLA2MAPKAPK2ZAP70ITKSTAT3PTPN6PTPN18LYNMAP4K1CSKCYCSRAPGEF1LOC466968PTPN11RPS6KB1RELMAP3K7STAT1CRKLMAPK8NFATC3SOS1HCLS1PRKCDRB1PTK2BAKT1LCP2GAB2STAP1MAP2K2PIP4K2ALOC454721RELAPLCG2PIP5K1BARPC5SH2B2PIK3CGCCNA2SYKBLNKCREB1NCK1RPS6KA1RELSHC1


Description

The B cell receptor includes membrane and heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

Comments

GenMAPP notes 
NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP23(r20725) with a 80% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
89905view13:23, 6 October 2016MkutmonModified description
73859view00:58, 26 February 2014MaintBotupdated schema
67075view10:03, 26 June 2013Christine ChichesterOntology Term : 'B cell receptor signaling pathway' added !
41556view01:59, 2 March 2011MaintBotRemoved redundant pathway information and comments
35704view23:13, 12 February 2010AlexanderPico
34287view22:00, 9 December 2009MaintBotAutomatic update of empty xrefs
31593view22:06, 13 August 2009MaintBotFixed text labels
30477view21:34, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTR2GeneProduct746973 (Entrez Gene)
ACTR3GeneProduct459563 (Entrez Gene)
AKT1GeneProduct740898 (Entrez Gene)
ARPC1BGeneProduct463568 (Entrez Gene)
ARPC2GeneProduct459938 (Entrez Gene)
ARPC3GeneProduct738738 (Entrez Gene)
ARPC4GeneProduct
ARPC5GeneProduct457574 (Entrez Gene)
ATF2GeneProduct
ATP2B4GeneProduct457646 (Entrez Gene)
BANK1GeneProduct471260 (Entrez Gene)
BAXGeneProduct747093 (Entrez Gene)
BCAR1GeneProduct454246 (Entrez Gene)
BCL10GeneProduct456984 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
BCL2L11GeneProduct459487 (Entrez Gene)
BCL6GeneProduct460926 (Entrez Gene)
BLKGeneProduct
BLNKGeneProduct450641 (Entrez Gene)
BRAFGeneProduct463781 (Entrez Gene)
BTKGeneProduct465759 (Entrez Gene)
CARD11GeneProduct463235 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CBLBGeneProduct460566 (Entrez Gene)
CCNA2GeneProduct461467 (Entrez Gene)
CCND2GeneProduct747123 (Entrez Gene)
CCND3GeneProduct462689 (Entrez Gene)
CCNE1GeneProduct455914 (Entrez Gene)
CD19GeneProduct454020 (Entrez Gene)
CD22GeneProduct450167 (Entrez Gene)
CD5GeneProduct737721 (Entrez Gene)
CD72GeneProduct465075 (Entrez Gene)
CD79AGeneProduct740560 (Entrez Gene)
CD79BGeneProduct454773 (Entrez Gene)
CD81GeneProduct449635 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene)
CDK4GeneProduct452025 (Entrez Gene)
CDK6GeneProduct746968 (Entrez Gene)
CDK7GeneProduct462378 (Entrez Gene)
CHST15GeneProduct466249 (Entrez Gene)
CHUKGeneProduct450673 (Entrez Gene)
CMTM3GeneProduct
CR2GeneProduct457690 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
CSKGeneProduct453745 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
CYCSGeneProduct744779 (Entrez Gene)
DAPP1GeneProduct461398 (Entrez Gene)
DOK1GeneProduct741064 (Entrez Gene)
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DUSP4GeneProduct464497 (Entrez Gene)
DUSP6GeneProduct452115 (Entrez Gene)
ELK1GeneProduct
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GAB2GeneProduct748918 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GSK3AGeneProduct456071 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene)
GTF2IGeneProduct450163 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct458163 (Entrez Gene)
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HNRNPKGeneProduct464554 (Entrez Gene)
IGHMGeneProduct
IKBKBGeneProduct472749 (Entrez Gene)
IKBKGGeneProduct743415 (Entrez Gene)
INPP5DGeneProduct470683 (Entrez Gene)
ITKGeneProduct735556 (Entrez Gene)
ITPR1GeneProduct460134 (Entrez Gene)
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LAT2GeneProduct
LCKGeneProduct
LCP2GeneProduct471734 (Entrez Gene)
LIME1GeneProduct
LOC454721GeneProduct454721 (Entrez Gene)
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LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
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MAPK4GeneProduct
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NEDD9GeneProduct462433 (Entrez Gene)
NFATC1GeneProduct455485 (Entrez Gene)
NFATC2GeneProduct469972 (Entrez Gene)
NFATC3GeneProduct454184 (Entrez Gene)
NFKBIAGeneProduct467426 (Entrez Gene)
PDK2GeneProduct468402 (Entrez Gene)
PDPK1GeneProduct
PIK3AP1GeneProduct450646 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PILRBGeneProduct
PIP4K2AGeneProduct742458 (Entrez Gene)
PIP4K2BGeneProduct746830 (Entrez Gene)
PIP4K2CGeneProduct467044 (Entrez Gene)
PIP5K1AGeneProduct457288 (Entrez Gene)
PIP5K1BGeneProduct464513 (Entrez Gene)
PIP5K1CGeneProduct455590 (Entrez Gene)
PLCG1GeneProduct458253 (Entrez Gene)
PLCG2GeneProduct454268 (Entrez Gene)
PLEKHA1GeneProduct450790 (Entrez Gene)
PLEKHA2GeneProduct472742 (Entrez Gene)
PPP3CAGeneProduct461403 (Entrez Gene)
PPP3CBGeneProduct450898 (Entrez Gene)
PPP3R1GeneProduct
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCEGeneProduct
PRKCQGeneProduct450288 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene)
PTK2GeneProduct464422 (Entrez Gene)
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PTPN11GeneProduct748225 (Entrez Gene)
PTPN18GeneProduct
PTPN6GeneProduct748032 (Entrez Gene)
PTPRCGeneProduct457607 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RAP2AGeneProduct452629 (Entrez Gene)
RAPGEF1GeneProduct464812 (Entrez Gene)
RASA1GeneProduct461762 (Entrez Gene)
RASGRP3GeneProduct470348 (Entrez Gene)
RB1GeneProduct452715 (Entrez Gene)
RELGeneProduct470380 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
RHOAGeneProduct461014 (Entrez Gene)
RPS6GeneProduct469976 (Entrez Gene)
RPS6KA1GeneProduct
RPS6KB1GeneProduct468426 (Entrez Gene)
SH2B2GeneProduct741557 (Entrez Gene)
SH3BP2GeneProduct461080 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SLA2GeneProduct735438 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SOS2GeneProduct452897 (Entrez Gene)
STAP1GeneProduct471228 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
SYKGeneProduct464586 (Entrez Gene)
TECGeneProduct461343 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)
VAV2GeneProduct
WASGeneProduct
ZAP70GeneProduct459427 (Entrez Gene)

Annotated Interactions

No annotated interactions
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