mRNA Processing (Pan troglodytes)

From WikiPathways

Jump to: navigation, search
1CF Isplicesome associated helicasesU2 snRNPsPolr2a5'exon 1AFormation of the Spliceosomal B complex3'35Poly(A)pb IICA(2)Formation of the active Spliceosomal C complexARngtt (capping enzyme)(1)P-3'SF3b14bSR-repressor proteins3'exon 1AGU6YYYYU1 snRNPexon 2U2CFI3'Poly(A) polymerase alphaPutative Alternative SplicingRegulatorsInternal methylation of mRNAmRNA polyadenylation5'Additional FactorsU4 snRNPmRNA cappingGUSR-proteinsCleavage of mRNA at the 3'-endYYYYFormation of the Spliceosomal C complex(3)Formation of pre-mRNPsiPoRnmt (methyltransferase)(2a)mRNA 3'-end processingProcessing of Intron-Containing Pre-mRNAAAAAAAAU5SR protein phosphatasesexon 2Cap BindingsnRNP Sm core complexU6 snRNPNote: New participating members shown at each stepexon 2SR-phosphatasesSR-proteins3'YYYYU2 snRNPYYYY5'65U5 snRNPA5'AGexon 2AmRNA splice site selectionAGFormation of the Spliceosomal B complexU53'3'YYYYAdditional SR proteinsAFormation of the Spliceosomal E complexSR protein kinasesRNAi pathwaymRNA CappingRNA helicase AFormation of the Spliceosomal E complexexon 1Formation of the Spliceosomal A complexCPSFCF IIRNA helicaseA3'SR-binding sitesPoly(A)-binding protein IIexon 2AGMethylation of mRNAPoly(A) pol5' G capSR-proteinsU4/U6AAUAAAdegradedsnRNP Sm core complex5'Cleavage at the 3'-Splice-Site and Exon LigationPrimary RNA transcriptCstF5'U2AFKinases Phosphorylating RS domains?Accessory ProteinsU1exon 1(2b)SR-kinases5'UG5'Regulation ofAlternative Splicingright click on blue text for detailed informationCstFhnRNPsLariat Formation and 5'-Splice Site CleavageFormation of pre-mRNPssnRNP Sm core complex5'Additional FactorsYYYY(2c)Piheterogeneous nuclear ribonucleoproteinsintronCPSFAGexon 1Misc.exon 2U4:U5:U6 tri-snRNP complexpre-mRNAU4Serine/Argenine Rich Proteins(SR)3'hnRNP regulatorsSR-binding sitesU2AFSpt5splicing factor SF3B5'AGCF IIUG3'Formation of the Spliceosomal A complexPU2 snRNP3'splicing factor SF3A5'exon 1Internal methylation of mRNAAdditional FactorsU1 snRNPmRNA splicing (major pathway)SSFA1CDC40ATPSRRM1CDC40PRPF18DHX16Rnu6RNPS1CELF4TMED10CPSF1SRSF5SNRNP70XRN2RBM5SNRNP40SF3A1DHX8SRSF10SSFA1HNRPH2SNRPNSNRPBPRPF40APHF5AGMPU1 snRNARBMXNONOSNRPD3HNRPA3P1SF3B1CPSF3CSTF2CSTF2TPRMT1SREK1CLK1HNRNPDDHX9SRPK2PRPF4HNRNPKHNRNPH2HNRNPLSRSF10CELF2SUGP1SUGP2NXF1CPSF2PCBP2LSM2SNRPD1PTBP1SFPQDNAJC8SF3A3POLR2APRPF4SNRPASNRPGU5 snRNALSM2FUSCLP1HNRNPUSPOPHNRNPMPTBP2PRPF8SRSF7PSKH1RNGTTPAPOLAU2AF2FAM177A1CSTF1U2DICER1SMC1ADHX38SRSF6CPSF4CELF1SNRPA1HNRNPCU2AF1HNRNPA1RBM17PRMT2NCBP2TRA2BPRPF6RBM39DHX15SRPK1HNRNPA2B1NUDT21RNMTSF3B3HNRNPRLSM7SNRPB2SRSF4U4 snRNASNRPNEFTUD2PRPF4BSRSF2CLASRPSNRPESF3A2CD2BP2SF3B2PPM1GTXNL4ASNRPD2SRSF1PABPN1CLK2NCBP1DDX1SSFA1DDX20PRPF3SFSWAPCLK4SF3B5NSEP1CLK3METTL3SNRPFHNRNPABSF3B4PRPF8SUPT5HSRSF9CSTF3SFRS3


Description

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).

The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Pathway adapted from http://www.reactome.org.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP411 (r95128) with a 92.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Carmody SR, Wente SR; ''mRNA nuclear export at a glance.''; J Cell Sci, 2009 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95768view14:20, 19 January 2018MkutmonHomology conversion update
71696view19:42, 17 October 2013MaintBotAutomated update of data sources
69321view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
67502view11:10, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
48173view20:36, 9 May 2012MaintBotUpdating from human to fix xrefs
41631view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
35271view20:26, 11 February 2010KhanspersAdded xrefs for GMP and ATP
35268view20:22, 11 February 2010KhanspersModified description
34358view22:25, 9 December 2009MaintBotAutomatic update of empty xrefs
33565view09:45, 1 December 2009MaintBotRemoved group label
31591view22:05, 13 August 2009MaintBotFixed text labels
30475view21:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
CD2BP2GeneProductENSPTRG00000007995 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10421
CDC40GeneProductENSPTRG00000018495 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51362
CELF1GeneProductENSPTRG00000052299 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10658
CELF2GeneProductENSPTRG00000002284 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10659
CELF4GeneProductENSPTRG00000009982 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:56853
CLASRPGeneProductENSPTRG00000022583 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11129
CLK1GeneProductENSPTRG00000012792 (Ensembl)
  • PMID: 15010457: Inhibitor John C. Bell, PhD

    Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

    We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1195
CLK2GeneProductENSPTRG00000001419 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1196
CLK3GeneProductENSPTRG00000007278 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1198
CLK4GeneProductENSPTRG00000017605 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:57396
CLP1GeneProductENSPTRG00000047318 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10978
CPSF1GeneProductENSPTRG00000051253 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:29894
CPSF2GeneProductENSPTRG00000006651 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:53981
CPSF3GeneProductENSPTRG00000011638 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51692
CPSF4GeneProductENSPTRG00000019453 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10898
CSTF1GeneProductENSPTRG00000013647 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1477
CSTF2GeneProductENSPTRG00000022090 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1478
CSTF2TGeneProductENSPTRG00000043097 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23283
CSTF3GeneProductENSPTRG00000003485 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1479
DDX1GeneProductENSPTRG00000011670 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1653
DDX20GeneProductENSPTRG00000001105 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11218
DHX15GeneProductENSPTRG00000015955 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1665
DHX16GeneProductENSPTRG00000017935 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8449
DHX38GeneProductENSPTRG00000008338 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9785
DHX8GeneProductENSPTRG00000009246 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1659
DHX9GeneProductENSPTRG00000001759 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1660
DICER1GeneProductENSPTRG00000023484 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23405
DNAJC8GeneProductENSPTRG00000000426 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:22826
EFTUD2GeneProductENSPTRG00000009287 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9343
FAM177A1GeneProductENSPTRG00000006259 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6729
FUSGeneProductENSPTRG00000008038 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2521
GMPMetabolite85-32-5 (CAS)
HNRNPA1GeneProductENSPTRG00000049417 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3178
HNRNPA2B1GeneProductENSPTRG00000019002 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3181
HNRNPABGeneProductENSPTRG00000017601 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3182
HNRNPCGeneProductENSPTRG00000006118 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3183
HNRNPDGeneProductENSPTRG00000016215 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3184
HNRNPH2GeneProductENSPTRG00000051626 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3187
HNRNPKGeneProductENSPTRG00000048500 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3190
HNRNPLGeneProductENSPTRG00000010941 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3191
HNRNPMGeneProductENSPTRG00000010424 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4670
HNRNPRGeneProductENSPTRG00000000324 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10236
HNRNPUGeneProductENSPTRG00000002182 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3192
HNRPA3P1GeneProduct
HNRPH2GeneProductENSPTRG00000046132 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3188
LSM2GeneProductENSPTRG00000017986 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:57819
LSM7GeneProductENSPTRG00000010233 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51690
METTL3GeneProductENSPTRG00000006127 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:56339
NCBP1GeneProductENSPTRG00000021167 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4686
NCBP2GeneProductENSPTRG00000048726 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:22916
NONOGeneProductENSPTRG00000022010 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4841
NSEP1GeneProductENSPTRG00000047244 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4904
NUDT21GeneProductENSPTRG00000008131 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11051
NXF1GeneProductENSPTRG00000003791 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10482
PABPN1GeneProductENSPTRG00000052729 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8106
PAPOLAGeneProductENSPTRG00000006704 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10914
PCBP2GeneProductNo homologues found for original id L:5094
PHF5AGeneProductENSPTRG00000014427 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84844
POLR2AGeneProductNo homologues found for original id L:5430
PPM1GGeneProductENSPTRG00000011768 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5496
PRMT1GeneProductENSPTRG00000040282 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3276
PRMT2GeneProductENSPTRG00000014027 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3275
PRPF18GeneProductENSPTRG00000002306 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8559
PRPF3GeneProductENSPTRG00000001254 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9129
PRPF40AGeneProductENSPTRG00000012543 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:55660
PRPF4BGeneProductENSPTRG00000017683 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8899
PRPF4GeneProductENSPTRG00000021274 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9128
PRPF6GeneProductENSPTRG00000013765 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:24148
PRPF8GeneProductENSPTRG00000039576 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10594
PSKH1GeneProductENSPTRG00000008252 (Ensembl)
  • PMID: 12466556
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5681
PTBP1GeneProductNo homologues found for original id L:5725
PTBP2GeneProductENSPTRG00000000987 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:58155
RBM17GeneProductENSPTRG00000002265 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84991
RBM39GeneProductENSPTRG00000049720 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9584
RBM5GeneProductENSPTRG00000014946 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10181
RBMXGeneProductNo homologues found for original id L:27316
RNGTTGeneProductENSPTRG00000018413 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8732
RNMTGeneProductENSPTRG00000009890 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8731
RNPS1GeneProduct
  • PMID: 14729963
  • No homologues found for original id L:10921
Rnu6RnaGenBank sequence: M10329
SF3A1GeneProductENSPTRG00000014240 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10291
SF3A2GeneProductENSPTRG00000010227 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8175
SF3A3GeneProductENSPTRG00000000559 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10946
SF3B1GeneProductENSPTRG00000012771 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23451
SF3B2GeneProductENSPTRG00000003912 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10992
SF3B3GeneProductENSPTRG00000008308 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23450
SF3B4GeneProductENSPTRG00000001243 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10262
SF3B5GeneProductENSPTRG00000018676 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:83443
SFPQGeneProductENSPTRG00000000518 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6421
SFRS3GeneProductENSPTRG00000041876 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6428
SFSWAPGeneProductENSPTRG00000005640 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6433
SMC1AGeneProductENSPTRG00000021927 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8243
SNRNP40GeneProductENSPTRG00000000455 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9410
SNRNP70GeneProductENSPTRG00000011277 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6625
SNRPA1GeneProductENSPTRG00000007513 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6627
SNRPAGeneProductENSPTRG00000011007 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6626
SNRPBGeneProductNo homologues found for original id L:6628
SNRPB2GeneProductENSPTRG00000013271 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6629
SNRPD1GeneProductENSPTRG00000050159 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6632
SNRPD2GeneProductENSPTRG00000011162 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6633
SNRPD3GeneProductENSPTRG00000014176 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6634
SNRPEGeneProductENSPTRG00000044898 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6635
SNRPFGeneProductENSPTRG00000047717 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6636
SNRPGGeneProductENSPTRG00000012029 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6637
SNRPNGeneProductENSPTRG00000006826 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6638
SPOPGeneProductENSPTRG00000009380 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8405
SREK1GeneProductENSPTRG00000016936 (Ensembl)
  • PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:140890
SRPK1GeneProductENSPTRG00000018094 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6732
SRPK2GeneProductENSPTRG00000019564 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6733
SRRM1GeneProductENSPTRG00000000349 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10250
SRSF10GeneProductENSPTRG00000044753 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10772
SRSF1GeneProductENSPTRG00000049077 (Ensembl)
  • Antagonist splicing factor
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6426
SRSF2GeneProductENSPTRG00000009692 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6427
SRSF4GeneProductENSPTRG00000000445 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6429
SRSF5GeneProductENSPTRG00000006488 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6430
SRSF6GeneProductENSPTRG00000044686 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6431
SRSF7GeneProductENSPTRG00000011851 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6432
SRSF9GeneProductENSPTRG00000005535 (Ensembl)
  • PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8683
SSFA1GeneProductENSPTRG00000052851 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4809
SUGP1GeneProductENSPTRG00000010737 (Ensembl)
  • inferred from: SURP 2, G patch protein, UniProt:O60378
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:57794
SUGP2GeneProductENSPTRG00000010727 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10147
SUPT5HGeneProductENSPTRG00000010971 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6829
TMED10GeneProductENSPTRG00000052822 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10972
TRA2BGeneProductENSPTRG00000015707 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6434
TXNL4AGeneProductENSPTRG00000052385 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10907
U1 snRNARnaGenBank sequence: J00645
U2AF1GeneProductENSPTRG00000045377 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7307
U2AF2GeneProductENSPTRG00000011523 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11338
U2GeneProductENSPTRG00000044342 (Ensembl)
  • GenBank sequence: K00027
  • Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6066
U4 snRNARnaGenBank sequence: M10328, M18004
U5 snRNARnaGenBank sequence: AB021173
XRN2GeneProductENSPTRG00000013308 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:22803

Annotated Interactions

No annotated interactions
Personal tools