Hedgehog Signaling Pathway (Pan troglodytes)

From WikiPathways

Jump to: navigation, search
1, 2CY->NUGODMitochondrionNucleusReaction through unknown mechanisms/moleculesPhosphorylationPM->ENProteolytic cleavageCYCytoplasmAcetylationPlasma membraneDephosphorylationAccession Number: NetPath 10; cellmap:10CY->NUMTGene SymbolEndoplasmic reticulumGolgi apparatusPMSumoylationDMolecule in the pathwayProteins in a complex interactionTranslocationLigandActivationRecruitmentGlycosylationPM->ENCY->NUAutophosphorylationDeubiquitinationECEndosomeExtracellularDeacetylationReceptorERInhibitionDUbiquitinationMolecular AssociationDesumoylationMethylationEnzyme complexCY->NUENCY->NUNUControlDemethylationCY->PM(Protein-protein interaction)PalmitoylationRAB23GLI1GLI2PTCHPTCH2GAS1HHIPIHHSHHSAP18SMOCCNB1PTCHPTCH2SIN3ACCNB1SUFUDYRK1AIGF2DHHSHHSKIPTCH2SHHGLI3GLI3RAB23IHHSUFUCDC2DHHSMOPTCHPTCHHHIPGLI1STK36SUFUDHHHHIPCDC2IHHGLI2SHHCREBBP


The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10


GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 68% conversion rate.

Quality Tags

Ontology Terms



  1. Mohler J; ''Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.''; Genetics, 1988 PubMed Europe PMC Scholia
  2. Lum L, Beachy PA; ''The Hedgehog response network: sensors, switches, and routers.''; Science, 2004 PubMed Europe PMC Scholia


View all...
69277view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67332view10:38, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
41586view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35743view23:52, 12 February 2010AlexanderPico
34315view22:10, 9 December 2009MaintBotAutomatic update of empty xrefs
31590view22:05, 13 August 2009MaintBotFixed text labels
30474view21:33, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
CCNB1GeneProduct461835 (Entrez Gene)
CDC2GeneProduct450481 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
DYRK1AGeneProduct458545 (Entrez Gene)
GAS1GeneProduct736324 (Entrez Gene)
GLI1GeneProduct452014 (Entrez Gene)
GLI2GeneProduct459582 (Entrez Gene)
GLI3GeneProduct463369 (Entrez Gene)
HHIPGeneProduct461521 (Entrez Gene)
IGF2GeneProduct742381 (Entrez Gene)
IHHGeneProduct470652 (Entrez Gene)
PTCH2GeneProduct469185 (Entrez Gene)
RAB23GeneProduct472043 (Entrez Gene)
SAP18GeneProduct452467 (Entrez Gene)
SHHGeneProduct743371 (Entrez Gene)
SIN3AGeneProduct453759 (Entrez Gene)
SMOGeneProduct463718 (Entrez Gene)
STK36GeneProduct459948 (Entrez Gene)
SUFUGeneProduct450699 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools