Apoptosis (Pan troglodytes)

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1Interferon regulatory factorspp53 RelatedFas LigandbDegradationpApoptosiseDNA FragmentationbIGF1R signaling pathwayeActivator of Cell DeathbMitochondrionInhibitor of Cell DeathCaspBADTP73MCL1LOC464876TRAF1LOC100614689NFKBIBNFKBIADIABLOTNFRSF1BNFKB1FASLGTNFRSF10BBCL2L11CASP9PRF1IGF2FASBIRC3TNFRSF1AJUNBBC3TRADDDFFBBIRC5LOC100611631CASP8IRF3CASP10CYCSPIK3R1CHUKMAPK10CASP2TP63NFKBIEBIDIKBKBTNFSF10IGF1RELAIRF7BADCFLARNFKBIABAK1FADDMAP3K1CYCTBCL2L1BNIP3LAKT1IGF1RCASP11CASP1IRF1TRAF3IRF2MAP2K4CDKN2ACASP6TP53RIPK1NFKB1IKBKGXIAPBAXGZMBIRF4CRADDTRADDNFKBIBHELLSTNFRSF1ATNFRSF21MDM2NFKBIETNFCASP4IRF5MYCBCL2PMAIP1APAF1TNFRSF25RIPK1BIRC2CASP7DFFARELAIRF6CASP3LOC742172LTA2


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r41184) with a 86% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC
  2. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
87013view14:45, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
69320view18:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
48144view18:35, 9 May 2012MaintBotUpdating from human to fix xrefs
41630view02:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
34357view22:24, 9 December 2009MaintBotAutomatic update of empty xrefs
33561view09:43, 1 December 2009MaintBotRemoved group label
30470view21:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct
APAF1GeneProduct452153 (Entrez Gene)
BADGeneProduct
BAK1GeneProduct462616 (Entrez Gene)
BAXGeneProduct747093 (Entrez Gene)
BBC3GeneProduct
BCL2GeneProduct738409 (Entrez Gene)
BCL2L11GeneProduct
BCL2L1GeneProduct458156 (Entrez Gene)
BIDGeneProduct458635 (Entrez Gene)
BIRC2GeneProduct451508 (Entrez Gene)
BIRC3GeneProduct451507 (Entrez Gene)
BIRC5GeneProduct455276 (Entrez Gene)
BNIP3LGeneProduct464069 (Entrez Gene)
CASP10GeneProduct
CASP11GeneProduct
CASP1GeneProduct451519 (Entrez Gene)
CASP2GeneProduct463804 (Entrez Gene)
CASP3GeneProduct461669 (Entrez Gene)
CASP4GeneProduct451518 (Entrez Gene)
CASP6GeneProduct736606 (Entrez Gene)
CASP7GeneProduct450745 (Entrez Gene)
CASP8GeneProduct746477 (Entrez Gene)
CASP9GeneProduct456457 (Entrez Gene)
CDKN2AGeneProduct465021 (Entrez Gene)
CFLARGeneProduct459872 (Entrez Gene)
CHUKGeneProduct450673 (Entrez Gene)
CRADDGeneProduct452128 (Entrez Gene)
CYCSGeneProduct
CYCTGeneProduct
DFFAGeneProduct457928 (Entrez Gene)
DFFBGeneProduct744932 (Entrez Gene)
DIABLOGeneProduct745126 (Entrez Gene)
FADDGeneProduct451389 (Entrez Gene)
FASGeneProduct738331 (Entrez Gene)
FASLGGeneProduct469584 (Entrez Gene)
GZMBGeneProduct452825 (Entrez Gene)
HELLSGeneProduct450624 (Entrez Gene)
IGF1GeneProduct741055 (Entrez Gene)
IGF1RGeneProduct453676 (Entrez Gene)
IGF2GeneProduct742381 (Entrez Gene)
IKBKBGeneProduct472749 (Entrez Gene)
IKBKGGeneProduct
IRF1GeneProduct745042 (Entrez Gene)
IRF2GeneProduct461629 (Entrez Gene)
IRF3GeneProduct
IRF4GeneProduct462386 (Entrez Gene)
IRF5GeneProduct472512 (Entrez Gene)
IRF6GeneProduct457701 (Entrez Gene)
IRF7GeneProduct
JUNGeneProduct456893 (Entrez Gene)
LOC100611631GeneProduct100611631 (Entrez Gene)
LOC100614689GeneProduct100614689 (Entrez Gene)
LOC464876GeneProduct464876 (Entrez Gene)
LOC742172GeneProduct742172 (Entrez Gene)
LTAGeneProduct494185 (Entrez Gene)
MAP2K4GeneProduct455065 (Entrez Gene)
MAP3K1GeneProduct471543 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MCL1GeneProduct457274 (Entrez Gene)
MDM2GeneProduct742141 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NFKBIAGeneProduct467426 (Entrez Gene)
NFKBIBGeneProduct456014 (Entrez Gene)
NFKBIEGeneProduct462730 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PMAIP1GeneProduct737247 (Entrez Gene)
PRF1GeneProduct450512 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
RIPK1GeneProduct462397 (Entrez Gene)
TNFGeneProduct494186 (Entrez Gene)
TNFRSF10BGeneProduct742898 (Entrez Gene)
TNFRSF1AGeneProduct466934 (Entrez Gene)
TNFRSF1BGeneProduct457968 (Entrez Gene)
TNFRSF21GeneProduct462749 (Entrez Gene)
TNFRSF25GeneProduct749145 (Entrez Gene)
TNFSF10GeneProduct460852 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
TP63GeneProduct460930 (Entrez Gene)
TP73GeneProduct
TRADDGeneProduct454154 (Entrez Gene)
TRAF1GeneProduct743748 (Entrez Gene)
TRAF3GeneProduct453178 (Entrez Gene)
XIAPGeneProduct473765 (Entrez Gene)

Annotated Interactions

No annotated interactions
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