Type II interferon signaling (IFNG) (Pan troglodytes)

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1T[P] [P]BPTPExtracellularSpaceCytoplasmBBORBPPlasmaMembraneORORAP[P]ORP[P]-P&&BT[P]OROONucleusIRF8HIST2H4CXCL10IL1BSTAT1IRF9STAT2IRF9STAT1ICAM1JAK1STAT1 [P]IRF2JAK1JAK2LOC473183G1P3SPI1IFNGR1EIF2AK2IRF9STAT1IFNGR1IRF9IRF9SOCS3STAT1IFNGR2TAP1NOS2STAT1OAS1IFNGSTAT1STAT2LOC473198IFNGR2IRF4IFNGSTAT1IFIT2IFNGR2CXCL9PSMB9JAK2GBP1PATR-BIFNGR1JAK1IRF1STAT1IFNGSOCS1STAT1STAT2STAT1CIITASTAT1STAT1IRF9IFNGR2LOC465566STAT2IFNGR1IRF9ISG15JAK2PRKCDIRF8IFNGSTAT1JAK2PTPN11STAT1JAK1STAT1REG1AIFNGSTAT1


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 72% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
87833view11:45, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
69281view18:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
41590view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
34320view22:12, 9 December 2009MaintBotAutomatic update of empty xrefs
33560view09:43, 1 December 2009MaintBotRemoved group label
31588view22:04, 13 August 2009MaintBotFixed text labels
30469view21:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CIITAGeneProduct453914 (Entrez Gene)
CXCL10GeneProduct461242 (Entrez Gene)
CXCL9GeneProduct471200 (Entrez Gene)
EIF2AK2GeneProduct459155 (Entrez Gene)
G1P3GeneProduct450178 (Entrez Gene)
GBP1GeneProduct738075 (Entrez Gene)
HIST2H4GeneProduct449585 (Entrez Gene)
ICAM1GeneProduct450196 (Entrez Gene)
IFIT2GeneProduct450585 (Entrez Gene)
IFNGGeneProduct449517 (Entrez Gene)
IFNGR1GeneProduct747276 (Entrez Gene)
IFNGR2GeneProduct470077 (Entrez Gene)
IL1BGeneProduct450200 (Entrez Gene)
IRF1GeneProduct745042 (Entrez Gene)
IRF2GeneProduct461629 (Entrez Gene)
IRF4GeneProduct462386 (Entrez Gene)
IRF8GeneProduct454294 (Entrez Gene)
IRF9GeneProduct744767 (Entrez Gene)
ISG15GeneProduct465390 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
LOC465566GeneProduct465566 (Entrez Gene)
LOC473183GeneProduct473183 (Entrez Gene)
LOC473198GeneProduct473198 (Entrez Gene)
NOS2GeneProduct455026 (Entrez Gene)
OAS1GeneProduct739129 (Entrez Gene)
PATR-BGeneProduct450202 (Entrez Gene)
PRKCDGeneProduct
PSMB9GeneProduct746436 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
REG1AGeneProduct459348 (Entrez Gene)
SOCS1GeneProduct737070 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SPI1GeneProduct
STAT1 [P]GeneProduct
STAT1GeneProduct459834 (Entrez Gene)
STAT2GeneProduct451996 (Entrez Gene)
TAP1GeneProduct471978 (Entrez Gene)

Annotated Interactions

No annotated interactions
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