Phospholipid Biosynthesis (Saccharomyces cerevisiae)

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1S-adenosyl-L-methionineCO2CMPphosphatidic acidS-adenosyl-homocysteineL-1-phosphatidyl-glycerolphosphatidyl-N-dimethylethanolamineL-1-phosphatidylglycerol-phosphateCMPCDP-diacylglycerolS-adenosyl-homocysteineS-adenosyl-homocysteinecardiolipinphosphatidyl-N-methylethanolamineCTPH2OS-adenosyl-L-methioninephosphatidylcholineS-adenosyl-L-methionineL-1-phosphatidylserineglycerol-3-phosphatephosphateCRD1L-serinePSD2L-1-phosphatidyl-ethanolaminePSD1glycerolCHO2OPI3CDS1PSG1OPI3pyrophosphateCHO1


Description

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Carman GM, Han GS; ''Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion.''; Biochim Biophys Acta, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
89492view13:41, 15 September 2016Mkutmonontology tag fix
89491view13:39, 15 September 2016Mkutmonremove space from ontology term id
69581view20:29, 8 July 2013MaintBotUpdated to 2013 gpml schema
67595view11:31, 26 June 2013DdiglesOntology Term : 'glycerophospholipid metabolic pathway' added !
53536view19:41, 8 November 2012EgonwMarked several DataNode's as Metabolite.
41806view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36631view22:34, 9 April 2010MaintBotDescription and bibliography added from SGD
20691view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Phospholipid Biosynthesis]] moved to [[Pathway:WP9]]: Moved to stable identifier
12818view08:04, 17 May 2008MaintBotautomated metabolite conversion
8885view14:11, 7 January 2008MaintBotAdded to category $category
8883view14:11, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CDS1GeneProductS000000233 (SGD)
CHO1GeneProductS000000828 (SGD)
CHO2GeneProductS000003389 (SGD)
CRD1GeneProductS000002301 (SGD)
L-1-phosphatidyl-ethanolamineMetabolite2644-64-6 (CAS)
L-serineMetabolite56-45-1 (CAS)
OPI3GeneProductS000003834 (SGD)
PSD1GeneProductS000005113 (SGD)
PSD2GeneProductS000003402 (SGD)
PSG1GeneProductS000000510 (SGD)
glycerolMetabolite56-81-5 (CAS)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions
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