Wnt Signaling Pathway (Pan troglodytes)

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1Ubiquitin Conjugating Enzyme-CateninPhosphorylatedPRecruitment to UnknownCytoskeletonUbiquitin TaggedB - CateninBNucleus26S Proteasome DegredationApoptosisFrizzled LigandsTranscriptional ActivationWNT7BMAPK10PAFAH1B1LDLRFZD8CTNNB1WNT4WNT6MYCPRKCHCCND1FZD9PRKCZRAC1FOSL1PPP2R5CAXIN1RHOAWNT5BPRKCAPRKCB1WNT2BPPP2R5EFZD6DVL3WNT10APRKCEDVL1WNT16APCMAPK9FZD2SFRP4WNT10BTCF-1/LEFPRKCQCSNK1ECCND2WNT7AWNT3AFBXW2JUNFZD7DVL2PRKD1FZD5CCND3FZD1PRKCDPLAUWNT11FRAT1WNT16WNT2FZD3WNT5AFZD10PRKCGGSK3BWNT3WNT1PRKCI


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 72% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
71688view19:42, 17 October 2013MaintBotAutomated update of data sources
69291view18:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67754view11:59, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41601view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35127view13:38, 11 February 2010Thomasconnected line
35119view13:24, 11 February 2010Thomasadded literature
35109view13:16, 11 February 2010ThomasModified description
34330view22:15, 9 December 2009MaintBotAutomatic update of empty xrefs
33559view09:43, 1 December 2009MaintBotRemoved group label
31587view22:04, 13 August 2009MaintBotFixed text labels
30468view21:31, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct461999 (Entrez Gene)
AXIN1GeneProduct453789 (Entrez Gene)
CCND1GeneProduct747688 (Entrez Gene)
CCND2GeneProduct747123 (Entrez Gene)
CCND3GeneProduct462689 (Entrez Gene)
CSNK1EGeneProduct458829 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
DVL1GeneProduct457191 (Entrez Gene)
DVL2GeneProduct455236 (Entrez Gene)
DVL3GeneProduct460882 (Entrez Gene)
FBXW2GeneProduct464698 (Entrez Gene)
FOSL1GeneProduct745919 (Entrez Gene)
FRAT1GeneProduct466169 (Entrez Gene)
FZD10GeneProduct467160 (Entrez Gene)
FZD1GeneProduct463524 (Entrez Gene)
FZD2GeneProduct
FZD3GeneProduct472726 (Entrez Gene)
FZD5GeneProduct470627 (Entrez Gene)
FZD6GeneProduct464327 (Entrez Gene)
FZD7GeneProduct459881 (Entrez Gene)
FZD8GeneProduct466040 (Entrez Gene)
FZD9GeneProduct472405 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene) MOUSE:KG38 MOUSE
JUNGeneProduct456893 (Entrez Gene)
LDLRGeneProduct455722 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
PAFAH1B1GeneProduct454422 (Entrez Gene)
PLAUGeneProduct738078 (Entrez Gene)
PPP2R5CGeneProduct453170 (Entrez Gene)
PPP2R5EGeneProduct452962 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCB1GeneProduct
PRKCDGeneProduct
PRKCEGeneProduct
PRKCGGeneProduct456276 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCIGeneProduct450143 (Entrez Gene)
PRKCQGeneProduct450288 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene)
RAC1GeneProduct
RHOAGeneProduct461014 (Entrez Gene)
SFRP4GeneProduct463356 (Entrez Gene)
TCF-1/LEFGeneProduct
WNT10AGeneProduct459952 (Entrez Gene)
WNT10BGeneProduct451870 (Entrez Gene)
WNT11GeneProduct451431 (Entrez Gene)
WNT16GeneProduct737375 (Entrez Gene)
WNT1GeneProduct742674 (Entrez Gene)
WNT2GeneProduct463673 (Entrez Gene)
WNT2BGeneProduct457103 (Entrez Gene)
WNT3GeneProduct468297 (Entrez Gene)
WNT3AGeneProduct469698 (Entrez Gene)
WNT4GeneProduct469212 (Entrez Gene)
WNT5AGeneProduct
WNT5BGeneProduct467191 (Entrez Gene)
WNT6GeneProduct
WNT7AGeneProduct
WNT7BGeneProduct

Annotated Interactions

No annotated interactions
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