Wnt Signaling Pathway and Pluripotency (Pan troglodytes)

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641Wnt ReceptorsTcf/Lef-1Frizzled LigandsProtein Kinase C+pDifferentiationCytoskeletonPromotes DifferentiationTRRecruitment to UnknownUbiquitin Conjugating Enzymebeta-cateninTRNucleusTRPP2A+p+pUbiquitin Taggedbeta-cateninStabilized beta-cateninPluripotencyPhosphorylated beta-cateninTRTR: Transcriptional RegulationTRbeta-cateninTcf/Lef-1Promotes PluripotencyBIOTcf/Lef-1TRIQ125GrouchoFOSL1DVL1JUNPPP2R5CPPP2R2ACTBP1FZD9MYCAPCWNT7ARACGAP1AXIN2CCND1PPP2R3AWNT2FZD8TCF7L1WNT6PRKCIPRKCQPPP2R2BMMP7LOC454731FZD4PRKCHCTNNB1CREBBPFZD5CSNK1ELRP5WNT10AMAPK10FBXW2PrkccWNT11WNT10BPPP2R2CFZD10DVL2ZBTB33WNT16CCND2MAP3K7NANOGWNT2BApoptosisPLAUPPP2CAFRAT1LOC465393WNT5ACTNND1WNT3AFZD3LDLRNFYAPPP2CBTCF7PPP2R5EPAFAH1B1ESRRBNKD2RHOAPPP2R4POU5F1WNT1PPARDAXIN1PPP2R1BFZD7MAPK9PRKCZCCND3WNT5BPRKCBLOC459203LOC100616510P300LRP6PPP2R3BSOX2FZD6PPM1JPRKCDTP53TCF7L2WNT11NKD1WNT4PRKD126S Proteasome DegradationPPP2R1AWNT9BCTBP2DVL3NLKCD44FZD1FOXD3WNT3PRKCALEF1


This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.

A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


This pathway was inferred from Homo sapiens pathway WP399(r45007) with a 82% conversion rate.

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  1. Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''''; , PubMed Europe PMC
  2. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC
  3. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC
  4. Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMed Europe PMC
  5. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  6. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,


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72123view07:36, 25 October 2013Mkutmonadded datasource for "26S Proteasome Degradation" and "Apoptosis"
69279view18:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
48146view18:37, 9 May 2012MaintBotUpdating from human to fix xrefs
41588view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
34317view22:10, 9 December 2009MaintBotAutomatic update of empty xrefs
33557view09:42, 1 December 2009MaintBotRemoved group label
31583view22:02, 13 August 2009MaintBotFixed text labels
30462view21:29, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APCGeneProduct461999 (Entrez Gene)
AXIN1GeneProduct453789 (Entrez Gene)
AXIN2GeneProduct468301 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
CCND2GeneProduct747123 (Entrez Gene)
CCND3GeneProduct462689 (Entrez Gene)
CD44GeneProduct451122 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
CSNK1EGeneProduct458829 (Entrez Gene)
CTBP2GeneProduct450810 (Entrez Gene)
CTNNB1GeneProduct450183 (Entrez Gene)
CTNND1GeneProduct743685 (Entrez Gene)
DVL1GeneProduct457191 (Entrez Gene)
DVL2GeneProduct455236 (Entrez Gene)
DVL3GeneProduct460882 (Entrez Gene)
ESRRBGeneProduct453056 (Entrez Gene)
FBXW2GeneProduct464698 (Entrez Gene)
FOSL1GeneProduct745919 (Entrez Gene)
FRAT1GeneProduct466169 (Entrez Gene)
FZD1GeneProduct463524 (Entrez Gene)
FZD3GeneProduct472726 (Entrez Gene)
FZD4GeneProduct466732 (Entrez Gene)
FZD5GeneProduct470627 (Entrez Gene)
FZD6GeneProduct464327 (Entrez Gene)
FZD7GeneProduct459881 (Entrez Gene)
FZD8GeneProduct466040 (Entrez Gene)
FZD9GeneProduct472405 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LDLRGeneProduct455722 (Entrez Gene)
LEF1GeneProduct461425 (Entrez Gene)
LOC100616510GeneProduct100616510 (Entrez Gene)
LOC454731GeneProduct454731 (Entrez Gene)
LOC459203GeneProduct459203 (Entrez Gene)
LOC465393GeneProduct465393 (Entrez Gene)
LRP5GeneProduct451380 (Entrez Gene)
LRP6GeneProduct465295 (Entrez Gene)
MAP3K7GeneProduct462888 (Entrez Gene)
MAPK10GeneProduct461358 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MMP7GeneProduct451509 (Entrez Gene)
MYCGeneProduct464393 (Entrez Gene)
NANOGGeneProduct748301 (Entrez Gene)
NKD1GeneProduct465164 (Entrez Gene)
NKD2GeneProduct461692 (Entrez Gene)
NLKGeneProduct739132 (Entrez Gene)
PAFAH1B1GeneProduct454422 (Entrez Gene)
PLAUGeneProduct738078 (Entrez Gene)
POU5F1GeneProduct744263 (Entrez Gene)
PPARDGeneProduct463188 (Entrez Gene)
PPP2CAGeneProduct471633 (Entrez Gene)
PPP2CBGeneProduct464100 (Entrez Gene)
PPP2R1AGeneProduct468983 (Entrez Gene)
PPP2R1BGeneProduct466778 (Entrez Gene)
PPP2R2AGeneProduct464068 (Entrez Gene)
PPP2R2BGeneProduct462170 (Entrez Gene)
PPP2R2CGeneProduct461101 (Entrez Gene)
PPP2R3AGeneProduct460715 (Entrez Gene)
PPP2R4GeneProduct464784 (Entrez Gene)
PPP2R5EGeneProduct452962 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCBGeneProduct453993 (Entrez Gene)
PRKCDGeneProduct460442 (Entrez Gene)
PRKCHGeneProduct746068 (Entrez Gene)
PRKCIGeneProduct450143 (Entrez Gene)
PRKCQGeneProduct450288 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PRKD1GeneProduct452834 (Entrez Gene)
RACGAP1GeneProduct451887 (Entrez Gene)
RHOAGeneProduct461014 (Entrez Gene)
SOX2GeneProduct460869 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
WNT10AGeneProduct459952 (Entrez Gene)
WNT10BGeneProduct451870 (Entrez Gene)
WNT11GeneProduct451431 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
WNT16GeneProduct737375 (Entrez Gene)
WNT1GeneProduct742674 (Entrez Gene)
WNT2GeneProduct463673 (Entrez Gene)
WNT2BGeneProduct457103 (Entrez Gene)
WNT3GeneProduct468297 (Entrez Gene)
WNT4GeneProduct469212 (Entrez Gene)
WNT5BGeneProduct467191 (Entrez Gene)
WNT9BGeneProduct468296 (Entrez Gene)
ZBTB33GeneProduct465831 (Entrez Gene)

Annotated Interactions

No annotated interactions
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