Kit Receptor Signaling Pathway (Pan troglodytes)

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TranslocationMitochondrionEnzyme complexECEndoplasmic reticulumMTCytoplasmDemethylationERAcetylationNUInhibitionDPM(Protein-protein interaction)ExtracellularDeubiquitinationDephosphorylationProteins in a complex interactionENDeacetylationDGlycosylationEndosomeAccession Number: NetPath 6; cellmap:6Golgi apparatusAutophosphorlationReceptorMolecule in the pathwayDesumoylationMethylationNucleusPlasma MembraneActivationPhosphorylationLigandCY->PMMolecular associationRecruitmentControlp85 complexProteolytic cleavageUbiquitinationGene SymbolCYSumoylationPalmitoylationGOReaction through unknown mechanisms/moleculesSTAT3STAT1FYNMAPK1PLCG1SPRED2HCKABL1YES1PRKCB1PLCE1LYNJAK2SOS1DOK1CSF2RBSOCS5SHC1PIK3R2DOK1TNFRSF10ACRKCBLSTAT5ASTAT5BEP300RPS6KA1MPDZBADGRAPGRB2GRB10PTPN11GRB7RAF1STAP1EPORAKT1RASA1MATKSOCS1INPP5DVAV2PIK3R1KITLGPIK3CGMAP2K1TECPRKCAVAV1CLTCMITFSH3KBP1FGRFESKITSH2B2BTKSRCSPRED1KITLGCBLBCRKLCISHSOCS6SOCS4PTPRUKITPTPN6HRAS


Description

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Comments

GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP304(r21319) with a 84% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
69270view18:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67430view11:00, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
41578view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35757view00:04, 13 February 2010AlexanderPico
34306view22:07, 9 December 2009MaintBotAutomatic update of empty xrefs
31578view22:01, 13 August 2009MaintBotFixed text labels
30455view21:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct464802 (Entrez Gene)
AKT1GeneProduct740898 (Entrez Gene)
BADGeneProduct
BTKGeneProduct465759 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CBLBGeneProduct460566 (Entrez Gene)
CISHGeneProduct470819 (Entrez Gene)
CLTCGeneProduct455168 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
CSF2RBGeneProduct458802 (Entrez Gene)
DOK1GeneProduct741064 (Entrez Gene)
EP300GeneProduct458862 (Entrez Gene)
EPORGeneProduct455728 (Entrez Gene)
FESGeneProduct453654 (Entrez Gene)
FGRGeneProduct739516 (Entrez Gene)
FYNGeneProduct462944 (Entrez Gene)
GRAPGeneProduct454496 (Entrez Gene)
GRB10GeneProduct463410 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GRB7GeneProduct454637 (Entrez Gene)
HCKGeneProduct458163 (Entrez Gene)
HRASGeneProduct466302 (Entrez Gene)
INPP5DGeneProduct470683 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
KITGeneProduct461316 (Entrez Gene)
KITLGGeneProduct452114 (Entrez Gene)
LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MATKGeneProduct
MITFGeneProduct460500 (Entrez Gene)
MPDZGeneProduct473169 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PLCE1GeneProduct450620 (Entrez Gene)
PLCG1GeneProduct458253 (Entrez Gene)
PRKCAGeneProduct454832 (Entrez Gene)
PRKCB1GeneProduct
PTPN11GeneProduct748225 (Entrez Gene)
PTPN6GeneProduct748032 (Entrez Gene)
PTPRUGeneProduct456692 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RASA1GeneProduct461762 (Entrez Gene)
RPS6KA1GeneProduct
SH2B2GeneProduct741557 (Entrez Gene)
SH3KBP1GeneProduct465527 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SOCS1GeneProduct737070 (Entrez Gene)
SOCS4GeneProduct452919 (Entrez Gene)
SOCS5GeneProduct459209 (Entrez Gene)
SOCS6GeneProduct455521 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SPRED1GeneProduct467654 (Entrez Gene)
SPRED2GeneProduct459284 (Entrez Gene)
SRCGeneProduct458229 (Entrez Gene)
STAP1GeneProduct471228 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
TECGeneProduct461343 (Entrez Gene)
TNFRSF10AGeneProduct743159 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)
VAV2GeneProduct
YES1GeneProduct455322 (Entrez Gene)

Annotated Interactions

No annotated interactions
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