MAPK Signaling Pathway (Pan troglodytes)

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Scaffold2-10111LegendCalcium channelsCalcium channelsHeteromeric G-proteinActivating mutationProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTRAF6MEF2CPSRFRPS6KA3PMAP2K3PELK4PRAP1APCRKIL1APDGFBAKT3ECSITMAP3K13RASGRP4MAP3K7PMAPK9PGRB2MKNK1PDUSP1STMN1PELK1PPPEGFRPPP3CBPPP3CCMAP4K1NFATC1PARRB2MAPTPRASGRP1RAP1BPCD14IKBKGBDNFDAXXMAPK10PTNLG1FMOSSTK4MAPK14PIKBKBPPARRB1LRRK2CASP3FLNAPRKACAMAPKAPK2PTNFRSF1AMAP3K14HSPB1PZAKGNA12TGFB1MAP3K1PMAP3K2PMAXPDUSP10RASGRF2MAP4K4PDGFRBTAB1MAP3K4GADD45AWnt signaling pathwayMAP2K5CDC25BPIL1R1RAC2PRKCDPPP5CMAP2K1PPRAC1PTPN7IL1R2TAB2TGFBR1MAPK1PPPTPRRPTPN5PLA2G4DPBRAFNTRK1ATF2PMAP2K4PLPSc-fosPRKCGMYCSOS2TGFB2ELK1PMAPK7PDUSP4CACNG3ApoptosisHSPA8MAPK12PMAPK8IP1IP3PPM1ACa2+IL1BELK4PTRAF2MAPK13PTAOK1MAP2K6PDUSP8AKT2MAPKAPK5PRASA2DUSP7PPP3R2FGFR1TGFB3PPP3CAEGFDDIT3PMAP3K6MAP3K8NGFCRKLTAOK2cAMPMAPK3PPMAPK8PNR4A1PCell cyclePRKCAATF4PNTF4PDGFAATF4PNTRK2FASLGPDGFRBPPM1BFGFR2CDC42FGFR3LAMTOR3FGFR4JUNPPSOS1JUNDPRRASHRASPPRPS6KA5PMAP3K12TP53PRRAS2PNFKB1GNG12PLA2G4CPNF1RASGRP2AKT1p53 signaling pathwayRASGRP3RASGRP4RASA1RASGRF1HSPA6Ca2+NTF3RAPGEF2Phosphatidylinositolsignaling systemPRKACBHSPA1APRKACGSTK3DUSP3MAP4K3CHUKPTGFBR2NFKB2MAP4K2RELAMAP2K7PRELBPPP3R1DUSP9NLKPDUSP2DAGDUSP16FASMKNK2PPLA2G4APNFATC3PMAP3K5PMAP3K11PTAOK3DUSP6MAP2K2PPPPP5D1MAPK11PRPS6KA4PMAPKAPK3PRAC3MAPK8IP2MAPK8IP3FLNBFLNCHSPA1BHSPA1LHSPA2MRASPNRASPKRASPRAF1PPLA2G4FPLA2G4BPPPLA2G4EPCACNG2CACNG5CACNG4CACNA2D3CACNG8CACNG7CACNG6CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1SCACNA2D1CACNB1CACNB2CACNB3CACNB4CACNG1CACNA1ICACNA1HCACNA1GCACNA2D2CACNA2D4FGF4FGF1FGF2FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGF10FGF11FGF12FGF13FGF14FGF20FGF21FGF22FGF23FGF18FGF17FGF16FGF19Fibroblast growth factorsFibroblast growthfactorsPAK2PAK1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC
  2. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  3. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  4. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  5. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  6. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  7. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  8. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  9. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  10. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  11. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106924view13:39, 17 September 2019MaintBotHMDB identifier normalization
105690view21:01, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96307view18:38, 7 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95782view14:34, 19 January 2018MkutmonHomology conversion update
72136view09:35, 25 October 2013Mkutmonadded datasource to pathway datanodes
69238view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67447view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
48170view20:32, 9 May 2012MaintBotUpdating from human to fix xrefs
41542view01:58, 2 March 2011MaintBotRemoved redundant pathway information and comments
35666view22:31, 12 February 2010KhanspersDescription and Bibliography
34274view21:55, 9 December 2009MaintBotAutomatic update of empty xrefs
33545view09:39, 1 December 2009MaintBotRemoved group label
31574view22:00, 13 August 2009MaintBotFixed text labels
30449view21:25, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSPTRG00000006775 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:207
AKT2GeneProductENSPTRG00000010992 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:208
AKT3GeneProductENSPTRG00000002174 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10000
ARRB1GeneProductENSPTRG00000004079 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:408
ARRB2GeneProductENSPTRG00000008601 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:409
ATF2GeneProductENSPTRG00000012660 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1386
ATF4GeneProductENSPTRG00000014398 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:468
ApoptosisPathwayWP254 (WikiPathways)
BDNFGeneProductENSPTRG00000040882 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:627
BRAFGeneProductENSPTRG00000051563 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:673
CACNA1AGeneProductENSPTRG00000010561 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000141837
CACNA1BGeneProductENSPTRG00000021608 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000148408
CACNA1CGeneProductENSPTRG00000004526 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000151067
CACNA1DGeneProductENSPTRG00000015026 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000157388
CACNA1EGeneProductENSPTRG00000001749 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000198216
CACNA1FGeneProductENSPTRG00000021888 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102001
CACNA1GGeneProductENSPTRG00000009405 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000006283
CACNA1HGeneProductENSPTRG00000007580 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196557
CACNA1IGeneProductENSPTRG00000014400 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000100346
CACNA1SGeneProductENSPTRG00000001827 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000081248
CACNA2D1GeneProductENSPTRG00000019350 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000153956
CACNA2D2GeneProductENSPTRG00000014964 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000007402
CACNA2D3GeneProductENSPTRG00000015031 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000157445
CACNA2D4GeneProductENSPTRG00000004521 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000151062
CACNB1GeneProductENSPTRG00000009085 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000067191
CACNB2GeneProductENSPTRG00000002339 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000165995
CACNB3GeneProductENSPTRG00000004886 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000167535
CACNB4GeneProductENSPTRG00000047916 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000182389
CACNG1GeneProductENSPTRG00000009561 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000108878
CACNG2GeneProductENSPTRG00000014315 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000166862
CACNG3GeneProductENSPTRG00000007896 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = H:CACNG3
CACNG4GeneProductENSPTRG00000050081 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075461
CACNG5GeneProductENSPTRG00000009559 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075429
CACNG6GeneProductENSPTRG00000043812 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000130433
CACNG7GeneProductENSPTRG00000011436 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105605
CACNG8GeneProductENSPTRG00000009560 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000142408
CASP3GeneProductENSPTRG00000016640 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:836
CD14GeneProductENSPTRG00000028584 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:929
CDC25BGeneProductENSPTRG00000013206 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:994
CDC42GeneProductENSPTRG00000051031 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:998
CHUKGeneProductENSPTRG00000033948 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000213341
CRKGeneProductENSPTRG00000045379 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1398
CRKLGeneProductENSPTRG00000047066 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1399
Ca2+MetaboliteHMDB0000464 (HMDB)
Cell cyclePathwayWP179 (WikiPathways)
DAGMetaboliteCHEBI:18035 (ChEBI)
DAXXGeneProductENSPTRG00000018045 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1616
DDIT3GeneProductENSPTRG00000022781 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1649
DUSP10GeneProductENSPTRG00000002005 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11221
DUSP16GeneProductENSPTRG00000004704 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000111266
DUSP1GeneProductENSPTRG00000017534 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1843
DUSP2GeneProductENSPTRG00000052076 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158050
DUSP3GeneProductENSPTRG00000038773 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000108861
DUSP4GeneProductENSPTRG00000020129 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1846
DUSP6GeneProductENSPTRG00000005282 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1848
DUSP7GeneProductENSPTRG00000014988 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1849
DUSP8GeneProductENSPTRG00000003154 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000184545
DUSP9GeneProductENSPTRG00000045215 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000130829
ECSITGeneProductENSPTRG00000010508 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51295
EGFGeneProductENSPTRG00000016367 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1950
EGFRGeneProductENSPTRG00000019196 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1956
ELK1GeneProductENSPTRG00000021850 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2002
ELK4GeneProductENSPTRG00000001902 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158711
FASGeneProductENSPTRG00000002730 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:355
FASLGGeneProductENSPTRG00000001690 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:356
FGF10GeneProductENSPTRG00000051664 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000070193
FGF11GeneProductENSPTRG00000050130 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000161958
FGF12GeneProductENSPTRG00000046123 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000114279
FGF13GeneProductENSPTRG00000022328 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000129682
FGF14GeneProductENSPTRG00000006008 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102466
FGF16GeneProductENSPTRG00000022533 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196468
FGF17GeneProductENSPTRG00000020046 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000158815
FGF18GeneProductENSPTRG00000017524 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000156427
FGF19GeneProductENSPTRG00000003998 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000162344
FGF1GeneProductENSPTRG00000017361 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000113578
FGF20GeneProductENSPTRG00000052715 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000078579
FGF21GeneProductENSPTRG00000011257 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105550
FGF22GeneProductENSPTRG00000043857 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000070388
FGF23GeneProductENSPTRG00000004551 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000118972
FGF2GeneProductENSPTRG00000051807 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138685
FGF3GeneProductENSPTRG00000004001 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000186895
FGF4GeneProductENSPTRG00000004000 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000075388
FGF5GeneProductENSPTRG00000016209 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138675
FGF6GeneProductENSPTRG00000046747 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000111241
FGF7GeneProductENSPTRG00000007057 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000140285
FGF8GeneProductENSPTRG00000002874 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000107831
FGF9GeneProductENSPTRG00000005698 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000102678
FGFR1GeneProductENSPTRG00000020176 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2260
FGFR2GeneProductENSPTRG00000003003 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000066468
FGFR3GeneProductENSPTRG00000015836 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000068078
FGFR4GeneProductENSPTRG00000017574 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000160867
FLNAGeneProductENSPTRG00000047682 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2316
FLNBGeneProductENSPTRG00000015054 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000136068
FLNCGeneProductENSPTRG00000019671 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000128591
GADD45AGeneProductENSPTRG00000000842 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1647
GNA12GeneProductENSPTRG00000018870 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2768
GNG12GeneProductENSPTRG00000048598 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000172380
GRB2GeneProductENSPTRG00000009642 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2885
HRASGeneProductENSPTRG00000034469 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000174775
HSPA1AGeneProductENSPTRG00000029753 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3303
HSPA1BGeneProductENSPTRG00000029753 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000204388
HSPA1LGeneProductENSPTRG00000029754 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000204390
HSPA2GeneProductENSPTRG00000006439 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000126803
HSPA6GeneProductENSPTRG00000040614 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000173110
HSPA8GeneProductENSPTRG00000004404 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3312
HSPB1GeneProductENSPTRG00000019319 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3315
IKBKBGeneProductENSPTRG00000020202 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3551
IKBKGGeneProductENSPTRG00000045486 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8517
IL1AGeneProductENSPTRG00000012371 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3552
IL1BGeneProductENSPTRG00000012372 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3553
IL1R1GeneProductENSPTRG00000012299 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3554
IL1R2GeneProductENSPTRG00000012297 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7850
IP3MetaboliteCHEBI:16595 (ChEBI)
JUNGeneProductNo homologues found for original id L:3725
JUNDGeneProductENSPTRG00000042879 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3727
KRASGeneProductENSPTRG00000004775 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3845
LAMTOR3GeneProductENSPTRG00000016310 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8649
LPSMetaboliteCHEBI:16412 (ChEBI)
LRRK2GeneProductENSPTRG00000004828 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000188906
MAP2K1GeneProductENSPTRG00000007193 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5604
MAP2K2GeneProductENSPTRG00000010294 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5605
MAP2K3GeneProductENSPTRG00000052693 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5606
MAP2K4GeneProductENSPTRG00000008783 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6416
MAP2K5GeneProductENSPTRG00000007207 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5607
MAP2K6GeneProductENSPTRG00000009588 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5608
MAP2K7GeneProductENSPTRG00000010409 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5609
MAP3K11GeneProductENSPTRG00000003886 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4296
MAP3K12GeneProductENSPTRG00000005019 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7786
MAP3K13GeneProductENSPTRG00000015700 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9175
MAP3K14GeneProductENSPTRG00000034405 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000006062
MAP3K1GeneProductENSPTRG00000016891 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4214
MAP3K2GeneProductENSPTRG00000012427 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10746
MAP3K4GeneProductENSPTRG00000046415 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4216
MAP3K5GeneProductENSPTRG00000024326 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4217
MAP3K6GeneProductENSPTRG00000000404 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9064
MAP3K7GeneProductENSPTRG00000018427 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6885
MAP3K8GeneProductENSPTRG00000002400 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1326
MAP4K1GeneProductENSPTRG00000010933 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:11184
MAP4K2GeneProductENSPTRG00000003847 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000168067
MAP4K3GeneProductENSPTRG00000011858 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8491
MAP4K4GeneProductENSPTRG00000012294 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9448
MAPK10GeneProductENSPTRG00000016244 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5602
MAPK11GeneProductENSPTRG00000050982 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000185386
MAPK12GeneProductENSPTRG00000014535 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6300
MAPK13GeneProductENSPTRG00000018098 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5603
MAPK14GeneProductENSPTRG00000018097 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1432
MAPK1GeneProductENSPTRG00000014120 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5594
MAPK3GeneProductENSPTRG00000007988 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5595
MAPK7GeneProductENSPTRG00000008867 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5598
MAPK8GeneProductENSPTRG00000002478 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5599
MAPK8IP1GeneProductENSPTRG00000003538 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000121653
MAPK8IP2GeneProductENSPTRG00000014549 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000008735
MAPK8IP3GeneProductENSPTRG00000007603 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000138834
MAPK9GeneProductENSPTRG00000017633 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5601
MAPKAPK2GeneProductENSPTRG00000001915 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9261
MAPKAPK3GeneProductENSPTRG00000014968 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000114738
MAPKAPK5GeneProductENSPTRG00000005465 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8550
MAPTGeneProductENSPTRG00000046868 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4137
MAXGeneProductENSPTRG00000006449 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4149
MEF2CGeneProductENSPTRG00000024214 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4208
MKNK1GeneProductENSPTRG00000046874 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:8569
MKNK2GeneProductENSPTRG00000010220 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000099875
MOSGeneProductENSPTRG00000020265 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4342
MRASGeneProductENSPTRG00000015445 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:22808
MYCGeneProductENSPTRG00000020581 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4609
NF1GeneProductENSPTRG00000008970 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000196712
NFATC1GeneProductENSPTRG00000010129 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4772
NFATC3GeneProductENSPTRG00000008260 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000072736
NFKB1GeneProductENSPTRG00000016320 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4790
NFKB2GeneProductENSPTRG00000002888 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000077150
NGFGeneProductENSPTRG00000050090 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000134259
NLKGeneProductENSPTRG00000008904 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51701
NR4A1GeneProductENSPTRG00000004966 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3164
NRASGeneProductENSPTRG00000001140 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4893
NTF3GeneProductENSPTRG00000004564 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000185652
NTF4GeneProductENSPTRG00000011274 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000225950
NTRK1GeneProductENSPTRG00000001478 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4914
NTRK2GeneProductENSPTRG00000021064 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000148053
PAK1GeneProductENSPTRG00000004101 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5058
PAK2GeneProductENSPTRG00000015787 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5062
PDGFAGeneProductENSPTRG00000043435 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000197461
PDGFBGeneProductENSPTRG00000014392 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5155
PDGFRBGeneProductENSPTRG00000044533 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000113721
PLA2G4AGeneProductENSPTRG00000001787 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000116711
PLA2G4BGeneProductENSPTRG00000042167 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000243708
PLA2G4CGeneProductENSPTRG00000011223 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000105499
PLA2G4DGeneProductENSPTRG00000006969 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000159337
PLA2G4EGeneProductENSPTRG00000006967 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000188089
PLA2G4FGeneProductENSPTRG00000006970 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000168907
PPM1AGeneProductENSPTRG00000006407 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5494
PPM1BGeneProductENSPTRG00000011881 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5495
PPP3CAGeneProductENSPTRG00000016315 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5530
PPP3CBGeneProductENSPTRG00000002631 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5532
PPP3CCGeneProductENSPTRG00000020059 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5533
PPP3R1GeneProductNo homologues found for original id L:5534
PPP3R2GeneProductNo homologues found for original id L:5535
PPP5CGeneProductENSPTRG00000011181 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5536
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKACAGeneProductENSPTRG00000010585 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5566
PRKACBGeneProductENSPTRG00000000899 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000142875
PRKACGGeneProductENSPTRG00000021003 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000165059
PRKCAGeneProductENSPTRG00000009557 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000154229
PRKCDGeneProductENSPTRG00000015023 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5580
PRKCGGeneProductENSPTRG00000011435 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5582
PTPN5GeneProductENSPTRG00000003430 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:84867
PTPN7GeneProductENSPTRG00000001848 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5778
PTPRRGeneProductENSPTRG00000005221 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5801
Phosphatidylinositol signaling systemPathway
RAC1GeneProductENSPTRG00000052694 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5879
RAC2GeneProductENSPTRG00000047213 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5880
RAC3GeneProductENSPTRG00000014331 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000169750
RAF1GeneProductENSPTRG00000014635 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5894
RAP1AGeneProductENSPTRG00000001102 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5906
RAP1BGeneProductNo homologues found for original id L:5908
RAPGEF2GeneProductENSPTRG00000016558 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000109756
RASA1GeneProductENSPTRG00000017062 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5921
RASA2GeneProductENSPTRG00000015472 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5922
RASGRF1GeneProductENSPTRG00000007353 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000058335
RASGRF2GeneProductENSPTRG00000017044 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5924
RASGRP1GeneProductENSPTRG00000006905 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10125
RASGRP2GeneProductENSPTRG00000003844 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000068831
RASGRP3GeneProductENSPTRG00000011824 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000152689
RASGRP4GeneProductENSPTRG00000048885 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000171777
RELAGeneProductENSPTRG00000003889 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000173039
RELBGeneProductENSPTRG00000011133 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000104856
RPS6KA3GeneProductENSPTRG00000052293 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6197
RPS6KA4GeneProductENSPTRG00000050834 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000162302
RPS6KA5GeneProductENSPTRG00000006631 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9252
RRAS2GeneProductENSPTRG00000003383 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000133818
RRASGeneProductENSPTRG00000011307 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000126458
SOS1GeneProductENSPTRG00000011857 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000115904
SOS2GeneProductENSPTRG00000006328 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6655
SRFGeneProductENSPTRG00000018189 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6722
STK3GeneProductENSPTRG00000020462 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:6788
STK4GeneProductENSPTRG00000013533 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000101109
STMN1GeneProductENSPTRG00000000369 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3925
TAB1GeneProductENSPTRG00000014395 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10454
TAB2GeneProductENSPTRG00000018690 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:23118
TAOK1GeneProductENSPTRG00000008948 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:57551
TAOK2GeneProductENSPTRG00000007977 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:9344
TAOK3GeneProductENSPTRG00000005513 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000135090
TGFB1GeneProductENSPTRG00000011021 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7040
TGFB2GeneProductENSPTRG00000001992 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7042
TGFB3GeneProductENSPTRG00000006562 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7043
TGFBR1GeneProductENSPTRG00000021182 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7046
TGFBR2GeneProductENSPTRG00000014711 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7048
TNFRSF1AGeneProductENSPTRG00000004570 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = En:ENSG00000067182
TNLG1FGeneProductENSPTRG00000017965 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7124
TP53GeneProductENSPTRG00000008703 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7157
TRAF2GeneProductENSPTRG00000021578 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7186
TRAF6GeneProductENSPTRG00000003510 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7189
Wnt signaling pathwayPathwayWP428 (WikiPathways)
ZAKGeneProductENSPTRG00000012644 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:51776
c-fosGeneProductENSPTRG00000047703 (Ensembl) Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2353
cAMPMetaboliteHMDB0000058 (HMDB)
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions
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