Estrogen signaling (Pan troglodytes)

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Gene expression(anti apoptotic)ERETATA Box bindingproteinTranslocationanti apoptosisHDACsMitochondrionTFIIB+pInhibitionTFIIFTFIIHTFIIDGene expression+pMAPKsTIFs+pRNA polymerase IIHistone Deacetylases (HDACs)ActivationRNA Pol IITranscription Initiation Factors (TIFs)NucleusTFIIETFIIAIKKsEstradiolIKBKBLOC466968POLR2CEstradiolCyclic AMPGNASSIN3AMAPK14POLR2GGNB1ERCC2CREB1CDK7ERCCNHBRCA1MP2K1_PANTREstradiolEstradiolGNGT1HDAC6ERTBPELKNCOR1ERGTF2BMNAT1SRCGTF2A2LOC738624CREB1POLR2KMAPK9NFKB1JUNILKERGTF2E1GRB2EstradiolTAF7ERTAF5SP1EstradiolEstradiolPOLR2ETAF6ERCCND1SHCCREBBPPOLR2BAKT1BCL2SOS1GTF2A2POLR2JHDAC4EP300EstradiolEstradiolERCHUKPIK3CATAF12POLR2AMAPK1ERLOC464259PRKACAERCC3TAF9GTF2E2POLR2FLOC462950IKK-gammaNFKB1BRAFLOC454721BCL2LOC465712FOSPOLR2HGPERTAF13TBPHRASGTF2H3GTF2H1ERPOLR2IGTF2H2GTF2F2GTF2H4


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 77% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  2. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  3. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
109477view11:17, 18 March 2020L DupuisFixed interactions
90716view20:20, 13 December 2016KhanspersModified title
88039view13:37, 25 July 2016SusanOntology Term : 'estrogen signaling pathway' added !
71871view08:57, 19 October 2013EgonwFixed the PubChem-compound data source.
69305view18:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
58913view04:49, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41615view02:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
34343view22:19, 9 December 2009MaintBotAutomatic update of empty xrefs
33533view09:35, 1 December 2009MaintBotRemoved group label
31569view21:58, 13 August 2009MaintBotFixed text labels
30437view21:22, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
BRAFGeneProduct463781 (Entrez Gene)
BRCA1GeneProduct449497 (Entrez Gene)
CCND1GeneProduct747688 (Entrez Gene)
CCNHGeneProduct739351 (Entrez Gene)
CDK7GeneProduct462378 (Entrez Gene)
CHUKGeneProductENSPTRG00000033948 (Ensembl)
CREB1GeneProduct459901 (Entrez Gene)
CREBBPGeneProduct467891 (Entrez Gene)
Cyclic AMPMetabolite6076 (PubChem-compound)
ELKGeneProduct
EP300GeneProduct458862 (Entrez Gene)
ERGeneProduct
ERCC2GeneProduct456124 (Entrez Gene)
ERCC3GeneProduct470526 (Entrez Gene)
EstradiolMetabolite5757 (PubChem-compound)
FOSGeneProduct453047 (Entrez Gene)
GNASGeneProduct469986 (Entrez Gene)
GNB1GeneProduct469458 (Entrez Gene)
GNGT1GeneProduct747170 (Entrez Gene)
GPERGeneProduct463215 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
GTF2A2GeneProduct453483 (Entrez Gene)
GTF2BGeneProduct743356 (Entrez Gene)
GTF2E1GeneProduct460615 (Entrez Gene)
GTF2E2GeneProduct464098 (Entrez Gene)
GTF2F2GeneProduct741868 (Entrez Gene)
GTF2H1GeneProduct748842 (Entrez Gene)
GTF2H2GeneProduct461830 (Entrez Gene)
GTF2H3GeneProduct452352 (Entrez Gene)
GTF2H4GeneProduct462549 (Entrez Gene)
HDAC4GeneProductHDAC4; histone deacetylase 4
HDAC6GeneProductHDAC6; histone deacetylase 6
HRASGeneProductENSPTRG00000034469 (Ensembl)
IKBKBGeneProductENSPTRG00000020202 (Ensembl)
IKK-gammaGeneProduct
ILKGeneProduct748941 (Entrez Gene)
JUNGeneProduct456893 (Entrez Gene)
LOC454721GeneProduct454721 (Entrez Gene) HDAC5; histone deacetylase 5
LOC462950GeneProduct462950 (Entrez Gene) HDAC2; histone deacetylase 2
LOC464259GeneProduct464259 (Entrez Gene) HDAC1; histone deacetylase 1
LOC465712GeneProduct465712 (Entrez Gene) HDAC8; histone deacetylase
LOC466968GeneProduct466968 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC738624GeneProduct738624 (Entrez Gene) HDAC3; histone deacetylase 3
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProductENSPTRG00000014120 (Ensembl)
MAPK9GeneProduct462336 (Entrez Gene)
MNAT1GeneProduct452954 (Entrez Gene)
MP2K1_PANTRGeneProductENSPTRG00000007193 (Ensembl)
NCOR1GeneProduct741384 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
PIK3CAGeneProduct460858 (Entrez Gene)
POLR2AGeneProduct454463 (Entrez Gene)
POLR2BGeneProduct461305 (Entrez Gene)
POLR2CGeneProduct454119 (Entrez Gene)
POLR2EGeneProduct456359 (Entrez Gene)
POLR2FGeneProduct458824 (Entrez Gene)
POLR2GGeneProduct740537 (Entrez Gene)
POLR2HGeneProduct471027 (Entrez Gene)
POLR2IGeneProduct746261 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct741257 (Entrez Gene)
PRKACAGeneProduct455776 (Entrez Gene)
SHCGeneProduct
SIN3AGeneProduct453759 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
SP1GeneProduct451939 (Entrez Gene)
SRCGeneProduct458229 (Entrez Gene)
TAF12GeneProduct456686 (Entrez Gene)
TAF13GeneProduct738503 (Entrez Gene)
TAF5GeneProduct735428 (Entrez Gene)
TAF6GeneProduct463588 (Entrez Gene)
TAF7GeneProduct471669 (Entrez Gene)
TAF9GeneProduct461833 (Entrez Gene)
TBPGeneProduct738472 (Entrez Gene)

Annotated Interactions

No annotated interactions
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