EGFR1 Signaling Pathway (Pan troglodytes)

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1PMGOPMPMPMCYCYPMProteolytic cleavageCYCYEndoplasmic reticulumCYCYMAMolecule in the pathwayENAutodephosphorylationPMGolgi apparatusProteins in a complex interactionDMAMethylationCYPMCYDesumoylationMAGene SymbolCYDeubiquitinationNUNUTranslocationDephosphorylationCYPMCYEnzyme complexECMADDNUERPMNUCYMANUMANUCYPMCYMAPMMACYLigandCYCYCYPMCYMACYNUNUPMNUPlasma membraneMAGlycosylationNUPMNUNUNUReaction through unknown mechanisms/moleculesCytoplasmNUMTMACYInhibitionPMActivationMAMANUPMDeacetylationCYPalmitoylationMA(Protein-protein interaction)AutophosphorylationMAAccession Number : NetPath 4; cellmap:4PMNUCYCYCYMolecular associationPhosphorylationMAControlNucleusMACYCYRecruitmentExtracellularNUAcetylationCYPMENNUCYCYUbiquitinationPMMitochondrionNUPMEndosomeNUReceptorPMMACYMACYCYENDemethylationMASumoylationPMCYCYMAFOXO1SH3BGRLBCAR1MAP2K1LOC464259CEACAM1MAP2K2PLEC1RAB5ASP1ATF1PTPN5JAK1PIK3R1PTPN11STAT5AGJA1PTPRRDUSP1FOXO1PLCG2GRB10SOCS3AKT1MAP3K2CBLCMAP3K3STAT1MAPK8ARAFEPPK1SMAD3ERRFI1SNCAMAPK1EPS8RPS6KA3EGFRCEBPBSMAD2VAV3GAB1MAP2K5PLSCR1JUNUSP6NLAPPL2NDUFA13ARF4TGIF1ARF4CBLBRFXANKPRKCASPRY2SMAD3RPS6KA5EPS15L1FOSCAV1SHC1HTTSMAD2REPS1STXBP1CASP9MAP3K14STAT3CSKKRT7NCK1RALBP1PLCG1ABI1SH2D3CGAB2RALBELF3HIP1KRASPEBP1MAP2K3MAPK14PIK3CGPTK6STAT1EGFPLD2KRT17SH3GL2PKN2HRASLOC459737DUSP1STAT3CAV2DOK2PLD1SIN3AMAP3K4SH3GL3NRASYWHABPTPN6APPL2ARF4EPS15RPS6KA1CREB1EEF1A1SOS1CEBPAVAV2PRKAR1APIK3CDDNM1CRKAPPL1STAT3PIK3R3WASLGRB14SOCS1PIK3CBPLD1CDC42EPN1SH2D3CPRKD1ZNF259PRKCGPITPNAPIK3CAWNK1SH3KBP1GAB1SHOC2EEF1A1TNIP1RBBP7TNK2RPS6KA2PTK2BSTAT5BGIT1GRB2MAPK7ZNF259MAP3K2GRB7EGFREGFPRKCISH3GL2ITCHMTA2HIST3H3INPPL1REPS2KRT8KRT18RALGDSMYCMAP2K7ELK4PLCG2APPL1PTPN6RAC1MAP3K1RAF1EGFRPIK3C2BPAK1EPS15STAT2RIPK1PRKCB1VAV1ASAP1APPL1ELK1STAT5ACBLRASA1MAP2K1AP2A1PTPN12STAT1NCK2SPRY2STAT2PIK3R2ELF3SHC1RPS6KA3MCF2STXBP1PLCG1CTNND1EGFBCAR1EGFRSRCKLF11SOS2PRKCZSNRPD2RGS16MAPK3MAPK1PRKCACAMK2AJUNDRAF1PXNJAK2CRKL


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 78% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
69215view18:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67180view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41517view01:56, 2 March 2011MaintBotRemoved redundant pathway information and comments
35720view23:29, 12 February 2010AlexanderPico
35436view11:33, 12 February 2010MichielAdded ref
34257view21:49, 9 December 2009MaintBotAutomatic update of empty xrefs
30429view21:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct450363 (Entrez Gene)
AKT1GeneProduct740898 (Entrez Gene)
AP2A1GeneProduct468956 (Entrez Gene)
APPL1GeneProduct460469 (Entrez Gene)
APPL2GeneProduct452197 (Entrez Gene)
ARAFGeneProduct
ARF4GeneProduct