IL-2 Signaling Pathway (Pan troglodytes)

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DMTAutophosphorylationAccession Number: NetPath 14DNUDDCY -> NUDNucleusDeubiquitinationERMolecule in the pathwayControlInhibitionDemethylationDCY -> NUReactions through unknown mechanisms/moleculesCytoplasmSumoylationNucleusEnzyme complexGolgi apparatusCY -> NUDDGOProteolytic cleavagePalmitolyationDeacetylation(Protein-protein interaction)UbiquitinationLigandExtracellularCY -> NUECPlasma membraneProteins in a complex interactionPhosphorylationCY -> NURecruitmentCY -> PMDMTDNUGlycosylationCY -> NUEndoplasmic reticulumTranslocationGene SymbolMitochondrionPhosphorylationDesumoylationDephosphorylationMolecular associationAcetylationCY -> NUCYReceptorPMEndosomeActivationENPM -> CYMethylationDDCY -> NUIL2STAT5AMAPK9BCL2CRKLJAK2SHBEIF3S9IL2CD53STAT5BNSEP1IL2MAPKAPK2PTPN6LYNAKT1NR3C1LCKFYNIRS1MAPK8TERTPIK3CAMKNK1SOS1STAT5BPIK3CDIL2RARAF1PRKCZSTAM2AKT1KRASETS1MAPK1RELAIL2RBIFNA1IL2PIK3CBSTAT1JAK3PTK2BNMIICAM1GAB2CISHMAP2K1NSEP1CRKFOXO3ARELATERTCRKPTPN11PLCB1STAT5ANFKB1SHC1JAK1FRAP1SYKMAPK3PIK3CGSOCS3MAPK3HSP90AA1VAV1IRS2GRB2MAPK14CREB1EIF4EGNB2L1SOCS1ETS2STAMMAP2K2CHUKRAF1ITM2BCBLNFKB1RPS6KB1IL2RGAKT1IL2PIK3R1PIK3R2STAT3MAPK1


IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.


This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 84% conversion rate.

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111045view12:25, 3 July 2020L DupuisConverted interactions to graphical lines in legend
89842view12:14, 6 October 2016Mkutmonremove GenMAPP notes
89841view12:14, 6 October 2016MkutmonModified description
73860view00:59, 26 February 2014MaintBotupdated schema
67372view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
41581view02:00, 2 March 2011MaintBotRemoved redundant pathway information and comments
35783view06:20, 13 February 2010MaintBotAdded description
34309view22:08, 9 December 2009MaintBotAutomatic update of empty xrefs
31561view21:55, 13 August 2009MaintBotFixed text labels
30424view21:17, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct740898 (Entrez Gene)
BCL2GeneProduct738409 (Entrez Gene)
CBLGeneProduct451690 (Entrez Gene)
CD53GeneProduct745007 (Entrez Gene)
CHUKGeneProduct450673 (Entrez Gene)
CISHGeneProduct470819 (Entrez Gene)
CREB1GeneProduct459901 (Entrez Gene)
CRKGeneProduct747142 (Entrez Gene)
CRKLGeneProduct470146 (Entrez Gene)
EIF4EGeneProduct468435 (Entrez Gene)
ETS2GeneProduct473996 (Entrez Gene)
FYNGeneProduct462944 (Entrez Gene)
GAB2GeneProduct748918 (Entrez Gene)
GNB2L1GeneProduct462344 (Entrez Gene)
GRB2GeneProduct737245 (Entrez Gene)
HSP90AA1GeneProduct743883 (Entrez Gene)
ICAM1GeneProduct450196 (Entrez Gene)
IL2GeneProduct461472 (Entrez Gene)
IL2RAGeneProduct450884 (Entrez Gene)
IL2RBGeneProduct470203 (Entrez Gene)
IL2RGGeneProduct465692 (Entrez Gene)
IRS1GeneProduct459985 (Entrez Gene)
IRS2GeneProduct452657 (Entrez Gene)
ITM2BGeneProduct452714 (Entrez Gene)
JAK1GeneProduct743373 (Entrez Gene)
JAK2GeneProduct464979 (Entrez Gene)
JAK3GeneProduct455848 (Entrez Gene)
KRASGeneProduct473387 (Entrez Gene)
LYNGeneProduct472771 (Entrez Gene)
MAP2K1GeneProduct450188 (Entrez Gene)
MAP2K2GeneProduct456390 (Entrez Gene)
MAPK14GeneProduct450161 (Entrez Gene)
MAPK1GeneProduct458680 (Entrez Gene)
MAPK3GeneProduct454037 (Entrez Gene)
MAPK8GeneProduct450445 (Entrez Gene)
MAPK9GeneProduct462336 (Entrez Gene)
MAPKAPK2GeneProduct744091 (Entrez Gene)
MKNK1GeneProduct469189 (Entrez Gene)
NFKB1GeneProduct461406 (Entrez Gene)
NMIGeneProduct470714 (Entrez Gene)
NR3C1GeneProduct471681 (Entrez Gene)
PIK3CAGeneProduct460858 (Entrez Gene)
PIK3CBGeneProduct471079 (Entrez Gene)
PIK3CDGeneProduct457922 (Entrez Gene)
PIK3CGGeneProduct463649 (Entrez Gene)
PIK3R1GeneProduct461836 (Entrez Gene)
PIK3R2GeneProduct455855 (Entrez Gene)
PLCB1GeneProduct469875 (Entrez Gene)
PRKCZGeneProduct743533 (Entrez Gene)
PTK2BGeneProduct464073 (Entrez Gene)
PTPN11GeneProduct748225 (Entrez Gene)
PTPN6GeneProduct748032 (Entrez Gene)
RAF1GeneProduct460182 (Entrez Gene)
RELAGeneProduct466665 (Entrez Gene)
RPS6KB1GeneProduct468426 (Entrez Gene)
SHBGeneProduct465107 (Entrez Gene)
SHC1GeneProduct457351 (Entrez Gene)
SOCS1GeneProduct737070 (Entrez Gene)
SOCS3GeneProduct454921 (Entrez Gene)
SOS1GeneProduct459171 (Entrez Gene)
STAM2GeneProduct459661 (Entrez Gene)
STAMGeneProduct466269 (Entrez Gene)
STAT1GeneProduct459834 (Entrez Gene)
STAT3GeneProduct454682 (Entrez Gene)
STAT5AGeneProduct454681 (Entrez Gene)
STAT5BGeneProduct454679 (Entrez Gene)
SYKGeneProduct464586 (Entrez Gene)
TERTGeneProduct471443 (Entrez Gene)
VAV1GeneProduct455647 (Entrez Gene)

Annotated Interactions

No annotated interactions
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