Cell cycle (Gallus gallus)

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signalingpathwayMAPKUbiquitin1+p+u-pHistone Deacetylases+p+p+pTranscription Factor E2F-pDNADNA+pMeG2+p+p+uGrowth FactorDNA biosynthesisMCM (Mini-ChromosomeMaintenance) complexCondensinG1ee+pSS-phase proteins+u+pSecurin+pHDACDNA damage checkpointp16,15,18,19p21+pe+p+pApoptosisORC (OriginRecognition complex)proteolysis+uGrowth Factor withdrawalR-point(Start)p27,57+pemediated+pSeparin+p+u+pMPEG1RBL1ORC5LCCNA2CCNA2CDK4CHEK2APC/CCDK2CDKN1BPCNARB1E2FSKP2BUB1BHDAC3MCM6CCNA1CDC6CCNB2BUB3ARFATMMCM514-3-3SCFORCHDAC7AGSK3BSMAD3HDAC6MCM7PTTG1PTTG2ATRUBE2FMAD2L1SMAD4CCNE2CDK2E2F1E2F3CDC25BSMC1L1CCND3CDC2PRKDCDBF4ORC3LESPL1HDAC4CDK6SKP2MDM2MCM2CCNB3RCJMB04_5e12ORC4LTP53CCNB1CDC45LCDKN1ABUB1CCNE1MAD1L1CDC7CDC14ACDH1E2F2ORC2LPKMYT1WEE1HDAC1HDAC2TGFB1CCNHCDC25ARB1CDC2GeneProductCDC14CMCM3MAD2L2ABL1CDK2ORC6LHDAC5CCND2RBL1E2F6TFDP1E2F4GADD45ASCFMCM4CCNA1CDKN2ARCJMB04_30p22MENPTTG3MCMTBC1D8RB1CDC20APC/CHDAC8CDC25CORC1LEP300CHEK1PLK1


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
109474view11:09, 18 March 2020L DupuisConverted interaction lines to graphical lines where applicable
86991view14:37, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
72064view17:30, 24 October 2013MaintBotremoved data source from nodes without identifier
68856view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
62677view18:31, 1 May 2013MaintBotUpdated Ensembl and UniProt data source
40994view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35366view09:15, 12 February 2010MartijnVanIerselModified description
33916view18:05, 9 December 2009MaintBotAutomatic update of empty xrefs
33514view15:18, 30 November 2009MaintBotRemoved group label
31554view21:53, 13 August 2009MaintBotFixed text labels
30413view21:14, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
14-3-3GeneProduct
ABL1GeneProduct417181 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/CGeneProduct
ARFGeneProduct
ATMGeneProduct395401 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProduct424777 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProduct421226 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct378922 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct423949 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct418901 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct396172 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProductCCNB1; cyclin B1
CCNB2GeneProduct415400 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProductCCNB3; cyclin B
CCND2GeneProduct374047 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct419928 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct426117 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct420231 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct427328 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct424466 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14CGeneProduct427473 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct424563 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2GeneProduct396252 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25AGeneProduct420375 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25BGeneProductCDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25CGeneProductCDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC45LGeneProduct416776 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProductCDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct424507 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct415860 (Entrez Gene)
CDK2GeneProductCDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProductCDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct420558 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct
CDKN1BGeneProduct769872 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct395077 (Entrez Gene)
CHEK1GeneProductCHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct768913 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4GeneProduct420536 (Entrez Gene) ASK; activator of S phase kinas
E2FGeneProduct
E2F1GeneProduct396142 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProductE2F2; E2F transcription factor 2
E2F3GeneProduct420824 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct769430 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F6GeneProductE2F6; E2F transcription factor 6
EP300GeneProduct418000 (Entrez Gene) EP300; E1A binding protein p300
ESPL1GeneProduct425536 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct693255 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProductGeneProduct
HDAC1GeneProduct373961 (Entrez Gene) HDAC1; histone deacetylase 1
HDAC2GeneProduct395635 (Entrez Gene) HDAC2; histone deacetylase 2
HDAC3GeneProduct395506 (Entrez Gene) HDAC3; histone deacetylase 3
HDAC4GeneProduct374207 (Entrez Gene) HDAC4; histone deacetylase 4
HDAC5GeneProductHDAC5; histone deacetylase 5
HDAC6GeneProductHDAC6; histone deacetylase 6
HDAC7AGeneProduct426885 (Entrez Gene) HDAC7A; histone deacetylase 7
HDAC8GeneProduct422182 (Entrez Gene) HDAC8; histone deacetylase
MAD1L1GeneProduct427658 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct422675 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct419493 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MCM2GeneProduct416027 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct422043 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct426764 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct418058 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct424295 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProductMCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct395609 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct
MPEG1GeneProduct
ORCGeneProduct
ORC1LGeneProduct424640 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct424077 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct421822 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct424307 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct417714 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct415749 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct373984 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProductPKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct416575 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct395376 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct416158 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProduct386582 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct419126 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
RCJMB04_30p22GeneProduct420206 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
RCJMB04_5e12GeneProduct427820 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
SCFGeneProduct
SKP2GeneProduct427437 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct395132 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProductMADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1L1GeneProductSMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct428012 (Entrez Gene)
TFDP1GeneProduct418739 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct
TP53GeneProduct396200 (Entrez Gene)
UBE2FGeneProduct424015 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct423045 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]

Annotated Interactions

No annotated interactions
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