Proteasome Degradation (Gallus gallus)

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Oxidatively DamagedCytosolic ProteinsUnfolds and DegradesIntact ProteinsProteins to be DegradedProteasome 26 S(PA700) (ATP dependent)Presentation by MHC class 1Ubiquitin/ProteinProteasome 20SCatalytic Core (p45)Deubiquitinates proteinsBeta subunitsLid subunitsDegrades only PeptidesAlpha subunitsAMP Ubiquitin/E1 ComplexE3/Proteinp45 ATPase SubunitUbiquitin/E2 ComplexActivators of20S ComplexPSMC6PSMB2UBE2D3PSMB3UBE1PSMD8PSMD10PSMD13PSMA4PSMB8HLA-BNEDD4PSMD12PSMA7PSMB7PSMC5A1IMF0_CHICKPSMA2HLA-JPSMC5PSMA5PSMD4PSMB4PSMA6PSMB1RPN2ATPPSMD7HLA-GPSMD9PSMD11PSMB9PSMC3PSME3HLA-HPSMB6PSMB10RCJMB04_2h11HLA-FPSMD5PSMA1UBBUBE2BPSMC4NP_990156.1PSMD6PSMA3UbiquitinPSMB5UBCPSME2UBE2D2H2AFXHIST1H2ABHLA-EPSMC2PSMD3PSMD1HLA-CUBE2D1UBE1LPSMD2PSMC1PSME1RPN1HLA-AIFNG


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 56% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
87614view08:54, 25 July 2016LindarieswijkOntology Term : 'ubiquitin, ubiquitin-like/proteasome degradation pathway' added !
74215view10:31, 6 April 2014EgonwRemoved an unused and outdated Uniprot data source and added a missing metabolite ID.
68845view17:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
62673view18:31, 1 May 2013MaintBotUpdated Ensembl and UniProt data source
58778view22:16, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40983view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
33907view18:02, 9 December 2009MaintBotAutomatic update of empty xrefs
33511view15:17, 30 November 2009MaintBotRemoved group label
31552view21:52, 13 August 2009MaintBotFixed text labels
30410view21:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A1IMF0_CHICKGeneProductENSGALG00000014261 (Ensembl)
ATPMetaboliteCHEBI:15422 (ChEBI)
H2AFXGeneProduct
HIST1H2ABGeneProduct
HLA-AGeneProduct
HLA-BGeneProduct
HLA-CGeneProduct
HLA-EGeneProduct
HLA-FGeneProduct
HLA-GGeneProduct768350 (Entrez Gene)
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProduct396054 (Entrez Gene)
NEDD4GeneProduct415406 (Entrez Gene)
NP_990156.1GeneProductENSGALG00000016921 (Ensembl)
PSMA1GeneProduct395874 (Entrez Gene)
PSMA2GeneProduct420772 (Entrez Gene)
PSMA3GeneProduct423542 (Entrez Gene)
PSMA4GeneProduct415357 (Entrez Gene)
PSMA5GeneProduct426937 (Entrez Gene)
PSMA6GeneProduct423326 (Entrez Gene)
PSMA7GeneProduct395318 (Entrez Gene)
PSMB10GeneProduct
PSMB1GeneProduct421551 (Entrez Gene)
PSMB2GeneProduct419630 (Entrez Gene)
PSMB3GeneProduct419997 (Entrez Gene)
PSMB4GeneProduct429986 (Entrez Gene)
PSMB5GeneProduct
PSMB6GeneProductU13393
PSMB7GeneProduct378915 (Entrez Gene)
PSMB8GeneProduct
PSMB9GeneProduct
PSMC1GeneProduct395804 (Entrez Gene)
PSMC2GeneProduct417716 (Entrez Gene)
PSMC3GeneProduct423182 (Entrez Gene)
PSMC4GeneProductPRS6 HUMAN
PSMC5GeneProduct428274 (Entrez Gene) PRS6 HUMAN
PSMC6GeneProduct423586 (Entrez Gene)
PSMD10GeneProduct422351 (Entrez Gene)
PSMD11GeneProduct430878 (Entrez Gene)
PSMD12GeneProduct417425 (Entrez Gene)
PSMD13GeneProduct422989 (Entrez Gene)
PSMD1GeneProduct424926 (Entrez Gene)
PSMD2GeneProduct425294 (Entrez Gene)
PSMD3GeneProduct426133 (Entrez Gene)
PSMD4GeneProduct
PSMD5GeneProduct417125 (Entrez Gene)
PSMD6GeneProduct416079 (Entrez Gene)
PSMD7GeneProduct415869 (Entrez Gene)
PSMD8GeneProduct
PSMD9GeneProduct416853 (Entrez Gene)
PSME1GeneProduct
PSME2GeneProduct
PSME3GeneProduct420017 (Entrez Gene)
RCJMB04_2h11GeneProduct426361 (Entrez Gene)
RPN1GeneProduct416017 (Entrez Gene)
RPN2GeneProduct419177 (Entrez Gene)
UBBGeneProduct396190 (Entrez Gene)
UBCGeneProduct396425 (Entrez Gene)
UBE1GeneProduct
UBE1LGeneProduct395178 (Entrez Gene)
UBE2BGeneProduct
UBE2D1GeneProduct423641 (Entrez Gene)
UBE2D2GeneProduct416137 (Entrez Gene)
UBE2D3GeneProduct
UbiquitinProtein

Annotated Interactions

No annotated interactions
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