Monoamine GPCRs (Gallus gallus)

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SerotoninReceptorsAdrenergicReceptorsGs PathwayDopamineReceptorsGq/G11 PathwayGi/Go PathwayGs PathwayHistamineReceptorsMuscarinicAcetylcholine ReceptorsAcetylcholine HTR2CHTR6CHRM2CHRM3HistamineDRD4HTR2BNorepinephrineCHRM4ADRA1DHTR5BHTR1BADRB1ADRB2DRD1HTR1AADRA1AHTR4DRD5CHRM1HTR7EpinephrineADRA1BDopamineHTR1DHTR2AMuscarineCHRM5DRD2DRD3ADRA2BHRH2HTR1FHTR5ASerotoninHRH1ADRA2AADRA2CADRB3HTR1E


Description

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia


Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 75% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
106131view12:03, 16 August 2019MaintBotHMDB identifier normalization
96088view19:07, 15 February 2018KhanspersModified description
74339view14:10, 13 April 2014EgonwAdded a few missing metabolite identifiers.
74177view15:41, 2 April 2014EgonwUpdated the PubChem-substance data source.
68822view17:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
40958view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
33885view17:54, 9 December 2009MaintBotAutomatic update of empty xrefs
33509view15:16, 30 November 2009MaintBotRemoved group label
31550view21:52, 13 August 2009MaintBotFixed text labels
30408view21:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADRA1AGeneProduct428203 (Entrez Gene)
ADRA1BGeneProduct373890 (Entrez Gene)
ADRA1DGeneProduct422933 (Entrez Gene)
ADRA2AGeneProduct428980 (Entrez Gene)
ADRA2BGeneProduct427631 (Entrez Gene)
ADRA2CGeneProduct428799 (Entrez Gene)
ADRB1GeneProduct430991 (Entrez Gene)
ADRB2GeneProduct427623 (Entrez Gene)
ADRB3GeneProduct
Acetylcholine MetaboliteHMDB0000895 (HMDB)
CHRM1GeneProduct
CHRM2GeneProduct418126 (Entrez Gene)
CHRM3GeneProduct396364 (Entrez Gene)
CHRM4GeneProduct423195 (Entrez Gene)
CHRM5GeneProduct428881 (Entrez Gene)
DRD1GeneProduct427633 (Entrez Gene)
DRD2GeneProduct428252 (Entrez Gene)
DRD3GeneProduct770757 (Entrez Gene)
DRD4GeneProduct423016 (Entrez Gene)
DRD5GeneProduct428795 (Entrez Gene)
DopamineMetaboliteCHEBI:18243 (ChEBI)
EpinephrineMetaboliteHMDB0000068 (HMDB)
HRH1GeneProduct
HRH2GeneProduct427635 (Entrez Gene)
HTR1AGeneProduct431581 (Entrez Gene)
HTR1BGeneProduct421858 (Entrez Gene)
HTR1DGeneProduct769107 (Entrez Gene)
HTR1EGeneProduct771973 (Entrez Gene)
HTR1FGeneProduct427963 (Entrez Gene)
HTR2AGeneProduct428070 (Entrez Gene)
HTR2BGeneProduct395581 (Entrez Gene)
HTR2CGeneProduct428707 (Entrez Gene)
HTR4GeneProduct416150 (Entrez Gene)
HTR5AGeneProduct428409 (Entrez Gene)
HTR5BGeneProduct
HTR6GeneProduct430019 (Entrez Gene)
HTR7GeneProduct423794 (Entrez Gene)
HistamineMetaboliteCHEBI:18295 (ChEBI)
MuscarineMetabolite9676 (PubChem-substance)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetaboliteCHEBI:28790 (ChEBI)

Annotated Interactions

No annotated interactions
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