Nuclear Receptors (Gallus gallus)

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1NR3 SUPERFAMILYVitamin D3 ReceptorActivated ReceptorNuclear receptor TLXHepatocyte Nuclear FactorCoup Transcription FactorNR4 SUPERFAMILYNR1 SUPERFAMILYProgesterone ReceptorNR2 SUPERFAMILYNuclear Receptor RORNR0 SUPERFAMILYThyroid ReceptorOrphan NuclearPeroxisome ProliferatorEstrogen ReceptorOrphan ReceptorAndrogen ReceptorRetinoic Acid Receptor RXRSteroidogenic ReceptorNR5 SUPERFAMILYOxysterols ReceptorRetinoic Acid ReceptorOrphan Nuclear ReceptorSteroid Hormone ReceptorReceptorGlucocorticoid ReceptorOrphan ReceptorESRRAESR2PPARGNR2C2NR5A2NR2F1RORAVDRPPARDROR1NR0B1NR1I2RXRBTHRBTHRBESRRBNR3C1RARGNR2F2RORCNR4A1PPARANR2E1NR4A2NR1D2PPARGPGRRARANR5A1ESR1RXRAARTHRARXRGHNF4ANR1H2NR1H3NR2F6RARGNR1I3RARB


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a ligand a molecule which affects the receptor's behavior is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed in more detail below, nuclear receptors may be classified either according to mechanism or homology. Source: Wikipedia (wikipedia:Nuclear_receptor)


This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 65% conversion rate.

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Ontology Terms



  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


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78403view10:25, 7 January 2015MaintBotadded missing graphIds
73651view09:52, 12 February 2014MkutmonModified description
69971view21:13, 11 July 2013MaintBotupdating to 2013 schema
69970view21:13, 11 July 2013MaintBot
67534view11:22, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
41020view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35770view00:11, 13 February 2010AlexanderPico
33941view18:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33501view15:13, 30 November 2009MaintBotRemoved group label
30400view21:09, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ARGeneProduct422165 (Entrez Gene)
ESR1GeneProduct396099 (Entrez Gene)
ESR2GeneProduct395575 (Entrez Gene)
ESRRBGeneProduct771938 (Entrez Gene)
HNF4AGeneProduct419198 (Entrez Gene)
NR0B1GeneProduct395285 (Entrez Gene)
NR1D2GeneProduct396125 (Entrez Gene)
NR1H3GeneProduct395221 (Entrez Gene)
NR1I3GeneProduct395439 (Entrez Gene)
NR2C2GeneProduct395253 (Entrez Gene)
NR2E1GeneProduct396082 (Entrez Gene)
NR2F2GeneProduct386585 (Entrez Gene)
NR2F6GeneProduct474359 (Entrez Gene)
NR3C1GeneProduct416343 (Entrez Gene)
NR4A2GeneProduct424320 (Entrez Gene)
NR5A1GeneProduct395960 (Entrez Gene)
NR5A2GeneProduct395961 (Entrez Gene)
PGRGeneProduct396198 (Entrez Gene)
PPARAGeneProduct374120 (Entrez Gene)
PPARDGeneProduct395479 (Entrez Gene)
PPARGGeneProduct373928 (Entrez Gene)
RARAGeneProduct395213 (Entrez Gene)
RARBGeneProduct396266 (Entrez Gene)
ROR1GeneProduct395179 (Entrez Gene)
RORAGeneProduct415377 (Entrez Gene)
RXRAGeneProduct417143 (Entrez Gene)
RXRGGeneProduct396231 (Entrez Gene)
THRAGeneProduct396251 (Entrez Gene)
THRBGeneProduct396431 (Entrez Gene)
VDRGeneProduct395988 (Entrez Gene)

Annotated Interactions

No annotated interactions
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