Regulation of Actin Cytoskeleton (Gallus gallus)

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GFLamellipodiaActomyosinassembly contraction+pPI3KGPCRGrowth Factor (GF)Filipodiastress fiberChemotactic factorFocal adhesionassemblyRASFocal adhesion pathwayGPCRActin polymerizationstress fiber-p?Chemotatic factorActin polymerizationFocal adhesion pathwayActin polymerizationGene ExpressionRTKRTKPI3KMAPK SignalingpathwayRASFocal complexassemblyStabilizationof actinAdherens junction pathwayGRLF1FGF15MAPK4FGF17PIP4K2AFGFR2LPSRAC1P4RHOAPAK2BAIAP2ARPC5TMSB4XFGF11FGF2EGFRGNA12RAC2LIMK1ARHGEF4FGF12MAP2K1FGFR1SSH1DIAP1PAK1MOSDOCK1FGF20EGFFGF7PAK7NCKAP1FGF4EZRPDGFRBSSH3LOC426359SOS1LOC442775GNA13CD14RCJMB04_4h19ARHGEF6RAF1PDGFBPAK4BDKRB2MYH10FGF3CYFIP2F2RFGF23PIP2CFL1PAK6CDC42SSH2RCJMB04_20j15ENAHCFL2RCJMB04_4h19NRASMAPK1c3orf10CHRM5PTK2C11orf13CSKRCJMB04_4h19APCFGF21ABI2PDGFRARDXMSNCHRM4FGFR4RRASRCJMB04_22k13RCJMB04_1h13MAPK3VIL1BAIAP2RCJMB04_1h13PIP5KL1INS2Apc2CRKARHGEF6BCAR1DIAP3FGFR3PIK3C2GAcetylcholinePIP4K2BMYL3BDKRB1FGD1FGF1PIP5K1ACHRM1KRASVCLPIP4K2AFGF6MRASROCK2ARHGEF7WASF1SOS2FGF16PXNPIK3C3GNG12PIK3R5FGF10F2RCJMB04_23c5SLC9A1PAK3ITGA1PIP3PIK3R4FGF8MAP2K2BRAFPIK3R3Pik3c2bCHRM2IQGAP1PFN1FGF13RRAS2RAC3FGF22PIK3CGPIP2FGF9MYLKFGF18GSNBradykininRAC1FGF5MYL1PDGFAVCLPIK3CBWASPIK3CAGIT1ROCK1RCJMB04_5i17FGF14CHRM3PIP5K2CFN1RCJMB04_1h13INS1PIP5K1CPIK3R1ARPC5PIK3R2PIK3CDPFN1ARHGEF1VAV1PIK3C2A


Description

No description

Comments

GenMAPP notes 
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
GenMAPP remarks 
Adapted from KEGG (right-click to see notes)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP51(r20783) with a 76% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
109469view10:59, 18 March 2020L DupuisConverted interaction lines to graphical lines where applicable
72069view17:52, 24 October 2013MaintBotUpdated data sources
68796view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67625view11:35, 26 June 2013DdiglesOntology Term : 'cell adhesion signaling pathway' added !
47796view16:38, 6 April 2012Khanspersupdated xrefs
40928view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
33859view17:45, 9 December 2009MaintBotAutomatic update of empty xrefs
33495view15:12, 30 November 2009MaintBotRemoved group label
31542view21:49, 13 August 2009MaintBotFixed text labels
30393view21:07, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABI2GeneProduct424108 (Entrez Gene)
APCGeneProduct415607 (Entrez Gene)
ARHGEF1GeneProduct
ARHGEF4GeneProduct424761 (Entrez Gene)
ARHGEF6GeneProduct422247 (Entrez Gene)
ARHGEF7GeneProduct418761 (Entrez Gene)
ARPC5GeneProduct429075 (Entrez Gene)
AcetylcholineMetabolite
Apc2GeneProduct
BAIAP2GeneProduct422077 (Entrez Gene)
BCAR1GeneProduct415691 (Entrez Gene)
BDKRB1GeneProduct772372 (Entrez Gene)
BDKRB2GeneProduct428906 (Entrez Gene)
BRAFGeneProduct396239 (Entrez Gene)
BradykininMetabolite
C11orf13GeneProduct
CD14GeneProduct100194427 (Entrez Gene)
CDC42GeneProduct395917 (Entrez Gene)
CFL1GeneProduct100309654 (Entrez Gene)
CFL2GeneProduct423320 (Entrez Gene)
CHRM1GeneProduct
CHRM2GeneProduct418126 (Entrez Gene)
CHRM3GeneProduct396364 (Entrez Gene)
CHRM4GeneProduct423195 (Entrez Gene)
CHRM5GeneProduct428881 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CSKGeneProduct396396 (Entrez Gene)
CYFIP2GeneProduct416246 (Entrez Gene)
DIAP1GeneProduct
DIAP3GeneProduct
DOCK1GeneProduct423960 (Entrez Gene)
EGFGeneProduct408035 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
ENAHGeneProduct374180 (Entrez Gene)
EZRGeneProduct395701 (Entrez Gene)
F2GeneProduct395306 (Entrez Gene)
F2RGeneProduct427212 (Entrez Gene)
FGD1GeneProduct
FGF10GeneProduct395432 (Entrez Gene)
FGF11GeneProduct
FGF12GeneProduct395704 (Entrez Gene)
FGF13GeneProduct414831 (Entrez Gene)
FGF1GeneProduct396094 (Entrez Gene)
FGF14GeneProduct395554 (Entrez Gene)
FGF15GeneProduct
FGF16GeneProduct422330 (Entrez Gene)
FGF17GeneProduct
FGF18GeneProduct395453 (Entrez Gene)
FGF20GeneProduct428779 (Entrez Gene)
FGF21GeneProduct
FGF22GeneProduct
FGF23GeneProduct428104 (Entrez Gene)
FGF2GeneProduct396413 (Entrez Gene)
FGF3GeneProduct396267 (Entrez Gene)
FGF4GeneProduct428857 (Entrez Gene)
FGF5GeneProduct770457 (Entrez Gene)
FGF6GeneProduct768907 (Entrez Gene)
FGF7GeneProduct415439 (Entrez Gene)
FGF8GeneProduct396313 (Entrez Gene)
FGF9GeneProduct378917 (Entrez Gene)
FGFR1GeneProduct396516 (Entrez Gene)
FGFR2GeneProduct396259 (Entrez Gene)
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FGFR4GeneProduct
FN1GeneProduct396133 (Entrez Gene)
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GNA12GeneProduct769924 (Entrez Gene)
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GRLF1GeneProduct425730 (Entrez Gene)
GSNGeneProduct395774 (Entrez Gene)
INS1GeneProduct
INS2GeneProduct
IQGAP1GeneProduct415591 (Entrez Gene)
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LOC426359GeneProduct426359 (Entrez Gene)
LOC442775GeneProduct
LPSMetaboliteC00338 (KEGG Compound)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK3GeneProduct
MAPK4GeneProduct
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MRASGeneProduct395149 (Entrez Gene)
MSNGeneProduct
MYH10GeneProduct396465 (Entrez Gene)
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MYL3GeneProduct396067 (Entrez Gene)
MYLKGeneProduct396445 (Entrez Gene)
NCKAP1GeneProduct424000 (Entrez Gene)
NRASGeneProduct419885 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PAK2GeneProduct424860 (Entrez Gene)
PAK3GeneProduct422342 (Entrez Gene)
PAK4GeneProduct770462 (Entrez Gene)
PAK6GeneProduct428837 (Entrez Gene)
PAK7GeneProduct416734 (Entrez Gene)
PDGFAGeneProduct374196 (Entrez Gene)
PDGFBGeneProduct374128 (Entrez Gene)
PDGFRAGeneProduct395509 (Entrez Gene)
PDGFRBGeneProduct770488 (Entrez Gene)
PFN1GeneProduct
PIK3C2AGeneProduct423070 (Entrez Gene)
PIK3C2GGeneProduct418181 (Entrez Gene)
PIK3C3GeneProduct
PIK3CAGeneProduct424971 (Entrez Gene)
PIK3CBGeneProduct424826 (Entrez Gene)
PIK3CDGeneProduct419444 (Entrez Gene)
PIK3CGGeneProduct417706 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PIK3R3GeneProduct429096 (Entrez Gene)
PIK3R4GeneProduct428449 (Entrez Gene)
PIK3R5GeneProduct417319 (Entrez Gene)
PIP2MetaboliteC04637 (KEGG Compound)
PIP3MetaboliteC05981 (KEGG Compound)
PIP4K2AGeneProduct420504 (Entrez Gene)
PIP4K2BGeneProduct419999 (Entrez Gene)
PIP5K1AGeneProduct429983 (Entrez Gene)
PIP5K1CGeneProduct420072 (Entrez Gene)
PIP5K2CGeneProduct
PIP5KL1GeneProduct
PTK2GeneProduct396416 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
Pik3c2bGeneProduct419822 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAC1P4GeneProduct
RAC2GeneProduct418044 (Entrez Gene)
RAC3GeneProduct395870 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RCJMB04_1h13GeneProduct415296 (Entrez Gene)
RCJMB04_20j15GeneProduct427243 (Entrez Gene)
RCJMB04_22k13GeneProduct396020 (Entrez Gene)
RCJMB04_23c5GeneProduct373918 (Entrez Gene)
RCJMB04_4h19GeneProduct396526 (Entrez Gene)
RCJMB04_5i17GeneProduct415419 (Entrez Gene)
RDXGeneProduct395511 (Entrez Gene)
RHOAGeneProduct395442 (Entrez Gene)
ROCK1GeneProduct373970 (Entrez Gene)
ROCK2GeneProduct374182 (Entrez Gene)
RRASGeneProduct
RRAS2GeneProduct423062 (Entrez Gene)
SLC9A1GeneProduct419580 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
SOS2GeneProduct423572 (Entrez Gene)
SSH1GeneProduct427699 (Entrez Gene)
SSH2GeneProduct417586 (Entrez Gene)
SSH3GeneProduct
TMSB4XGeneProduct408047 (Entrez Gene)
VAV1GeneProduct
VCLGeneProduct396422 (Entrez Gene)
VIL1GeneProduct396423 (Entrez Gene)
WASGeneProduct
WASF1GeneProduct421761 (Entrez Gene)
c3orf10GeneProduct

Annotated Interactions

No annotated interactions
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