Estrogen metabolism (Gallus gallus)

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2, 4, 876776771676663677758766657767561671157DNA adductsDNA adductsDNA adductsDNA adductsEstrone sulfateSuperoxideEstradiol-3,4-quinone4-Hydroxyestradiol-3-glucuronideEstrone-3,4-semiquinone2-hydroxy-estradiol-2-glucuronide2-MethoxyestroneUGT1A8Estradiol-3-glucuronideUGT1A8UGT1A8SuperoxideUGT2B74-Methoxyestrone-3-glucuronideSULT1A1UGT1A1UGT1A1OxygenARSDNQO14-hydroxyestrone-3-glucuronideUGT1A1CYP1A14-hydroxyestradiol4-hydroxy-estradiol-sulfateUGT2B7NP_001001751.1SuperoxideCOMTSULT1A1UGT2B7COMTUGT1A8UGT1A8Superoxide2-hydroxyestradiol-3-glucuronideCYP1B1Estradiol-17-glucuronideUGT1A84-Methoxyestradiol-3-glucuronideCYP1A1Estrone-17-glucuronideEstradiolCOMTOxygenEstrone-2,3-semiquinoneOxygen2-HydroxyestradiolUGT1A8Estrone-2,3-quinone2-hydroxy-estradiol-sulfateARSENQO14-Methoxyestradiol4-Methoxyestrone2-MethoxyestradiolEstrone-3,4-quinone2-HydroxyestroneEstroneCYP1A2UGT1A1GSTA1_CHICK2-Methoxyestrone 3-glucuronideUGT1A3UGT1A8UGT1A9GSTM12-Hydroxyestrone-3-glucuronideEstradiol-2,3-quinoneUGT1A8UGT2B7Estrone-3-glucuronideUGT1A8COMTUGT1A1STSEstradiol-2,3-semiquinoneUGT1A92-Methoxyestradiol-3-glucuronideUGT1A14-hydroxyestrone16a-HydroxyestroneNP_001001751.1OxygenEstradiol sulfateEstradiol-3,4-semiquinone4-hydroxy-estradiol-4-glucuronideSULT1E1CYP1A2SULT1A1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP697(r30275) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Shatalova EG, Walther SE, Favorova OO, Rebbeck TR, Blanchard RL; ''Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.''; Breast Cancer Res, 2005 PubMed Europe PMC
  2. Lakhani NJ, Sarkar MA, Venitz J, Figg WD; ''2-Methoxyestradiol, a promising anticancer agent.''; Pharmacotherapy, 2003 PubMed Europe PMC
  3. Abel EL, Lyon RP, Bammler TK, Verlinde CL, Lau SS, Monks TJ, Eaton DL; ''Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases.''; Chem Biol Interact, 2004 PubMed Europe PMC
  4. Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL; ''Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.''; Carcinogenesis, 2003 PubMed Europe PMC
  5. Bianco NR, Perry G, Smith MA, Templeton DJ, Montano MM; ''Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.''; Mol Endocrinol, 2003 PubMed Europe PMC
  6. Guillemette C, Belanger A, Lepine J; ''Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.''; Breast Cancer Res, 2004 PubMed Europe PMC
  7. Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG; ''Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC
  8. Raftogianis R, Creveling C, Weinshilboum R, Weisz J; ''Estrogen metabolism by conjugation.''; J Natl Cancer Inst Monogr, 2000 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106125view12:02, 16 August 2019MaintBotHMDB identifier normalization
88026view13:32, 25 July 2016SusanOntology Term : 'steroid metabolic pathway' added !
74178view15:42, 2 April 2014EgonwUpdated the PubChem-compound data source.
72044view16:17, 24 October 2013Mkutmonfixed unconnected lines
68839view17:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
58776view22:16, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40976view22:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
33901view18:00, 9 December 2009MaintBotAutomatic update of empty xrefs
33489view15:09, 30 November 2009MaintBotRemoved group label
30385view21:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
16a-HydroxyestroneMetaboliteHMDB0000335 (HMDB)
2-HydroxyestradiolMetaboliteHMDB0000338 (HMDB)
2-Hydroxyestrone-3-glucuronideMetabolite
2-HydroxyestroneMetaboliteHMDB0000343 (HMDB)
2-Methoxyestradiol-3-glucuronideMetabolite
2-MethoxyestradiolMetaboliteHMDB0000405 (HMDB)
2-Methoxyestrone 3-glucuronideMetaboliteHMDB0004482 (HMDB)
2-MethoxyestroneMetaboliteHMDB0000010 (HMDB)
2-hydroxy-estradiol-2-glucuronideMetabolite
2-hydroxy-estradiol-sulfateMetabolite
2-hydroxyestradiol-3-glucuronideMetabolite
4-Hydroxyestradiol-3-glucuronideMetabolite
4-Methoxyestradiol-3-glucuronideMetabolite
4-MethoxyestradiolMetaboliteHMDB0000405 (HMDB)
4-MethoxyestroneMetabolite
4-Methoxyestrone-3-glucuronideMetabolite
4-hydroxy-estradiol-4-glucuronideMetabolite
4-hydroxy-estradiol-sulfateMetabolite
4-hydroxyestradiolMetabolite
4-hydroxyestroneMetabolite
4-hydroxyestrone-3-glucuronideMetabolite
ARSDGeneProduct418658 (Entrez Gene)
ARSEGeneProduct418659 (Entrez Gene)
COMTGeneProductENSGALG00000002024 (Ensembl)
CYP1A1GeneProduct396051 (Entrez Gene)
CYP1A2GeneProduct414856 (Entrez Gene)
CYP1B1GeneProductENSGALG00000010556 (Ensembl)
EstradiolMetabolite
Estradiol sulfateMetabolite
Estradiol-17-glucuronideMetabolite
Estradiol-2,3-quinoneMetabolite
Estradiol-2,3-semiquinoneMetabolite
Estradiol-3,4-quinoneMetabolite
Estradiol-3,4-semiquinoneMetabolite
Estradiol-3-glucuronideMetaboliteHMDB0006224 (HMDB)
Estrone sulfateMetaboliteHMDB0001425 (HMDB)
Estrone-17-glucuronideMetaboliteHMDB0004483 (HMDB)
Estrone-2,3-quinoneMetabolite148381 (PubChem-compound)
Estrone-2,3-semiquinoneMetabolite
Estrone-3,4-quinoneMetabolite114862 (PubChem-compound)
Estrone-3,4-semiquinoneMetabolite
Estrone-3-glucuronideMetaboliteHMDB0004483 (HMDB)
EstroneMetaboliteHMDB0000145 (HMDB)
GSTA1_CHICKGeneProductENSGALG00000016325 (Ensembl)
GSTM1GeneProduct
NP_001001751.1GeneProductENSGALG00000004449 (Ensembl)
NQO1GeneProductENSGALG00000023437 (Ensembl)
OxygenMetaboliteHMDB0001377 (HMDB)
STSGeneProduct418654 (Entrez Gene)
SULT1A1GeneProduct
SULT1E1GeneProductENSGALG00000011812 (Ensembl)
SuperoxideMetaboliteHMDB0002168 (HMDB)
UGT1A1GeneProduct424028 (Entrez Gene)
UGT1A3GeneProduct
UGT1A8GeneProductENSGALG00000021016 (Ensembl)
UGT1A9GeneProduct771048 (Entrez Gene)
UGT2B7GeneProduct

Annotated Interactions

No annotated interactions
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