Id Signaling Pathway (Gallus gallus)

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(Protein-protein interaction)DeubiquitinationReaction through unknown mechanisms/moleculesPalmitoylationAcetylationDID Gene RegulationPMTECMitochondriaPInhibitionDPhosphorylationEnzyme complexDemethylationCytoplasmAccession Number: NetPath 5; cellmap:5Endoplasmic reticulumGOLigandDPlasma membraneDeacetylationNucleusCY -> NUDDesumoylationDSumoylationENExtracellularRecruitmentDephosphorylationMethylationUbiquitinationERControlProteolytic cleavageReceptorActivationProteins in a complex interactionMolecular associationMolecule in the PathwayCYPMAutophosphorylationGolgi apparatusTranslocationPGlycosylationEndosomeNUPAX2PI3KSMAD4PAX5RELATGIF1SMAD5ACVRL1CTNNB1CCNE1IFI16ELK1IGF1ID4RBL1ID3ID2BMP2ATF3CDK2TCRPAX8MYF5IRS1KDRID1IGF1RELK4ID2TCF12VEGFANFKB1PSMD4FLT1SREBF1SMAD4ERKLCKATF3MAPKTCF7L2MYF6MSCHES1RASMYOD1SMAD1CD40LGSMAD3SMAD5Gene SymbolMYOGSMAD3CCNA2BMP6NGFBSMAD1TCF3RB1RBL2ELK3EGFBMPR2TERT


Description

Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_5

Comments

GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 71% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
68857view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
67361view10:42, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
40995view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35749view23:58, 12 February 2010AlexanderPico
33917view18:05, 9 December 2009MaintBotAutomatic update of empty xrefs
31537view21:46, 13 August 2009MaintBotFixed text labels
30384view21:03, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVRL1GeneProduct
ATF3GeneProduct421369 (Entrez Gene)
BMP2GeneProduct378779 (Entrez Gene)
BMP6GeneProduct420868 (Entrez Gene)
BMPR2GeneProduct374147 (Entrez Gene)
CCNA2GeneProduct396172 (Entrez Gene)
CCNE1GeneProduct426117 (Entrez Gene)
CD40LGGeneProduct395485 (Entrez Gene)
CDK2GeneProduct
CTNNB1GeneProduct395964 (Entrez Gene)
EGFGeneProduct408035 (Entrez Gene)
ELK1GeneProduct
ELK3GeneProduct417919 (Entrez Gene)
ELK4GeneProduct419832 (Entrez Gene)
ERKGeneProduct
FLT1GeneProduct374100 (Entrez Gene)
Gene SymbolGeneProduct
HES1GeneProduct395128 (Entrez Gene)
ID1GeneProduct395282 (Entrez Gene)
ID2GeneProduct395852 (Entrez Gene)
ID3GeneProduct395281 (Entrez Gene)
ID4GeneProduct374150 (Entrez Gene)
IFI16GeneProduct
IGF1GeneProduct418090 (Entrez Gene)
IGF1RGeneProduct395889 (Entrez Gene)
IRS1GeneProduct429126 (Entrez Gene)
KDRGeneProduct395323 (Entrez Gene)
LCKGeneProduct
MAPKGeneProduct
MSCGeneProduct420179 (Entrez Gene)
MYF5GeneProduct395633 (Entrez Gene)
MYF6GeneProduct417873 (Entrez Gene)
MYOD1GeneProduct374048 (Entrez Gene)
MYOGGeneProduct374004 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NGFBGeneProduct396466 (Entrez Gene)
PAX2GeneProduct395574 (Entrez Gene)
PAX5GeneProduct387330 (Entrez Gene)
PAX8GeneProduct
PI3KGeneProduct
PSMD4GeneProduct
RASGeneProduct
RB1GeneProduct386582 (Entrez Gene)
RBL1GeneProduct419126 (Entrez Gene)
RBL2GeneProduct415721 (Entrez Gene)
RELAGeneProduct
SMAD1GeneProduct395680 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SMAD4GeneProduct
SMAD5GeneProduct395679 (Entrez Gene)
SREBF1GeneProduct373915 (Entrez Gene)
TCF12GeneProduct396334 (Entrez Gene)
TCF3GeneProduct395146 (Entrez Gene)
TCF7L2GeneProduct395508 (Entrez Gene)
TCRGeneProduct
TERTGeneProduct420972 (Entrez Gene)
TGIF1GeneProduct396339 (Entrez Gene)
VEGFAGeneProduct395909 (Entrez Gene)

Annotated Interactions

No annotated interactions
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