Transforming Growth Factor (TGF) Beta Signaling Pathway (Gallus gallus)

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1, 2RepressorsCofactorsR-SmadsCo-smadsligands:Accessory receptors:TGFbCo-SmadsRsmadsCofactorSMAD9FOSBMP4TGFB1ZFYVE9SMAD6NOGJUNFOXH1CREBBPSMAD7RUNX2BAMBISMAD5EP300SKIHRASTGIF1SMAD2ENGTGFB1SERPINE1IFNGTNFSKILSMAD1TGFBR1LEF1FKBP1ATFE3INHBAZNF423SPP1TGFBR3TNFRUNX3MAPK3ZEB2FSTRCJMB04_17i9THBS1EGFSTAT3NFKB1WNT1TGFBR2JAK1TGFBR1BMP4SMAD4SMAD2TGFBR2ITGB6SMAD3SMAD1LTBP1CTNNB1LIFMAPK9


Description

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

Comments

GenMAPP remarks 
edited by: Nathan Salomonis
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 76% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC
  2. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
87741view09:45, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87740view09:45, 25 July 2016MirellaKalafatiModified title
68806view17:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
40939view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33868view17:49, 9 December 2009MaintBotAutomatic update of empty xrefs
33486view15:09, 30 November 2009MaintBotRemoved group label
30381view21:03, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAMBIGeneProduct428413 (Entrez Gene)
BMP4GeneProduct396165 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
EGFGeneProduct408035 (Entrez Gene)
ENGGeneProduct771557 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
FKBP1AGeneProduct374233 (Entrez Gene)
FOSGeneProduct396512 (Entrez Gene)
FOXH1GeneProduct
FSTGeneProduct396119 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
IFNGGeneProduct396054 (Entrez Gene)
INHBAGeneProduct396361 (Entrez Gene)
ITGB6GeneProduct424191 (Entrez Gene)
JAK1GeneProduct395681 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
LEF1GeneProduct395865 (Entrez Gene)
LIFGeneProduct427718 (Entrez Gene)
LTBP1GeneProduct421461 (Entrez Gene)
MAPK3GeneProduct
MAPK9GeneProduct395983 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NOGGeneProduct373912 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RUNX2GeneProduct373919 (Entrez Gene)
RUNX3GeneProduct769687 (Entrez Gene)
SERPINE1GeneProduct
SKIGeneProduct428181 (Entrez Gene)
SKILGeneProduct396087 (Entrez Gene)
SMAD1GeneProduct395680 (Entrez Gene)
SMAD2GeneProduct395247 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SMAD4GeneProduct
SMAD5GeneProduct395679 (Entrez Gene)
SMAD6GeneProduct374096 (Entrez Gene)
SMAD7GeneProduct429683 (Entrez Gene)
SMAD9GeneProduct395543 (Entrez Gene)
SPP1GeneProduct395210 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
TFE3GeneProduct
TGFB1GeneProduct
TGFBR1GeneProduct374094 (Entrez Gene)
TGFBR2GeneProduct396399 (Entrez Gene)
TGFBR3GeneProduct374251 (Entrez Gene)
TGIF1GeneProduct396339 (Entrez Gene)
THBS1GeneProduct373987 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct
WNT1GeneProduct
ZEB2GeneProduct424306 (Entrez Gene)
ZFYVE9GeneProduct424639 (Entrez Gene)
ZNF423GeneProduct415738 (Entrez Gene)

Annotated Interactions

No annotated interactions
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