TNF-alpha NF-kB Signaling Pathway (Gallus gallus)

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Molecule in the pathwayAccession Number: NetPath 9; cellmap:9MTCY ->NUInhibitionMolecular association(Protein-protein interaction)NUControlProteins in a complex interactionPMAutophosphorylationGlycosylationUbiquitinationECCY ->NUERExtracellularMethylationCytoplasmEnzyme complexRecruitmentCYReaction through unknown mechanisms/moleculesDemethylationReceptorGolgi apparatusEndosomeTranslocationPlasma membraneLigandMitochondrionCY ->NUEndoplasmic reticulumActivationPalmitoylationProteolytic cleavageCY ->NUAcetylationNucleusGOPhosphorylationDeubiquitinationDENDephosphorylationDesumoylationCY ->NUDeacetylationSumoylationTNFAIP3UBE2D2TNFRSF11AMAP3K14FAF1YWHAERELMAP3K7IP2RPS6KA5CREBBPSMARCB1UBE2IGeneCASP7RPL6MAP3K1NFKBIANFKBIETXLNAIKBKGCFLARIKBKGTNFRSF1BTNIP2RPS13RCJMB04_4j14CRADDTRADDNR2C2PEBP1TNIP1TNFRSF1BPSMC2TNFRSF1AMAP3K7IP1POLR2HEIF4A3NKIRAS2BIRC3PPP1R13LIQGAP2NALP4HDAC1TRAF2SMARCA4TNFRSF8SUMO1NFKBIAMCM5CDC37YWHABTNFRSF1ATIFAPTK2RCJMB04_34f17PMLFKBP5FLNACSNK2A2RPL8TRADDMAP3K8PSMC1RELARIPK1RIPK2RELBRCJMB04_14f8ALPLMAP3K2POLR2LCASP10SKP1AGene SymbolPPP2CAHIST3H3TBK1GeneRCJMB04_5e12TNFRELAMARK2CASP8TRPC4APRNF25MAP3K3CUL1PSMD12BCL7APSMC3TRAF2ACTL6ANFKBIAGTF2IUNC5CLKTN1RCJMB04_17i9TANKTNFLRPPRCNFKBIZRCJMB04_2a4CDC34NR2C2COMMD1PDCD2CSNK2A1BTRCTRAF3POLR1ATRAF6AKT2RIPK3SMARCC2RIPK1RNF216TNFNFKB1PRKACATRAF4TRAF1HSP90AA1RASAL2DPF2MTIF2CASP3WDR68MCCTNFKPNA3TBK1COPS3PEG3KCNQ1BIRC2RELAPSMD13HDAC2CASP8AP2MAP3K7IP3TRAF2ZFAND5NFKBIBUBCH5CRCJMB04_19h23BIRC2BAG4CYLDDBC1YWHAHRELBMAP3K3FADDUSP2YWHAQIKBKETNFIKBKBRPS11RCJMB04_17o18PIAS3TNFRSF1APOLR1EASE1FANCD2BCL3TNFFBLPSMD3DAPNFKB2BIRC3HSPB1AKT1SRCRCJMB04_19h23SMARCE1PAPOLAAZI2GLG1RELPKN1HDAC6PSMD6SMARCC1RCJMB04_11l21PSMB5PSMD7NFKB1TRAIPPRKCZTRAF5TNFRSF1BGenePFDN2POLR1DG3BP2TRAF4AKAP8GNB2L1HSPCBCAV1POLR1CCASP2PTPN11GSK3BNSMAFTRAF1RPL30CSNK2BMCM7USP11KPNA2NFKB1RPL4RCJMB04_36h7CAPN3GAB1NKIRAS1RELAGenePOLR1BPSMD1


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 69% conversion rate.

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History

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CompareRevisionActionTimeUserComment
87787view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87785view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68867view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41006view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
33927view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33485view15:08, 30 November 2009MaintBotRemoved group label
31535view21:45, 13 August 2009MaintBotFixed text labels
30380view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTL6AGeneProduct424975 (Entrez Gene)
AKAP8GeneProduct426167 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
AKT2GeneProduct373973 (Entrez Gene)
ALPLGeneProduct396317 (Entrez Gene)
ASE1GeneProduct
AZI2GeneProduct420660 (Entrez Gene)
BAG4GeneProduct426776 (Entrez Gene)
BCL3GeneProduct
BCL7AGeneProduct416856 (Entrez Gene)
BIRC2GeneProduct374012 (Entrez Gene)
BIRC3GeneProduct
BTRCGeneProduct423854 (Entrez Gene)
CAPN3GeneProduct423233 (Entrez Gene)
CASP10GeneProduct424081 (Entrez Gene)
CASP2GeneProduct395857 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP8GeneProduct395284 (Entrez Gene)
CASP8AP2GeneProduct421810 (Entrez Gene)
CAV1GeneProduct373996 (Entrez Gene)
CDC34GeneProduct425483 (Entrez Gene)
CDC37GeneProduct395430 (Entrez Gene)
CFLARGeneProduct424080 (Entrez Gene)
COMMD1GeneProduct769006 (Entrez Gene)
COPS3GeneProduct416504 (Entrez Gene)
CRADDGeneProduct417900 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
CSNK2A1GeneProduct432370 (Entrez Gene)
CSNK2A2GeneProduct415626 (Entrez Gene)
CSNK2BGeneProduct
CUL1GeneProduct420783 (Entrez Gene)
CYLDGeneProduct415725 (Entrez Gene)
DAPGeneProduct420923 (Entrez Gene)
DBC1GeneProduct395098 (Entrez Gene)
DPF2GeneProduct374236 (Entrez Gene)
EIF4A3GeneProduct416704 (Entrez Gene)
FADDGeneProduct776859 (Entrez Gene)
FAF1GeneProduct424629 (Entrez Gene)
FANCD2GeneProduct415935 (Entrez Gene)
FBLGeneProduct
FKBP5GeneProduct421186 (Entrez Gene)
FLNAGeneProduct
G3BP2GeneProduct422576 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GLG1GeneProduct396492 (Entrez Gene)
GNB2L1GeneProduct417044 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene)
GTF2IGeneProduct417486 (Entrez Gene)
GeneGenePro