Hepatocyte growth factor receptor signaling (Gallus gallus)

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1CytoplasmChanges in Cytoskeletonand Cell mobilityRAC1pathwayRHOpathwayTrancriptionActinTranscriptionTranscriptionof Cox2AP-1ExtracellularAnoikisAKT PathwayCDC42pathwayPTENITGA1CRKLMetSTAT3ELK1CRKPAK1MAPK8MAP2K1PIK3CARASA1MAPK3MAPK1RAP1BPTK2PXNRAP1ARAF1HRASHGFDOCK1MAP4K1PXNGRB2PTK2BSRCMAP2K2SOS1PTK2BFOSPTK2GAB1PTPN11ITGB1RAPGEF1SRCJUNPPP


Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.


GenMAPP remarks 
Converted to human by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 78% conversion rate.

Quality Tags

Ontology Terms



  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia


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118803view07:47, 2 June 2021DeSlConverted "P" textlabels to states
118802view07:46, 2 June 2021DeSlConverted ReceptorSquare to MIM binding with lit. ref.
118801view07:44, 2 June 2021DeSlRemoved textLabel
118800view07:44, 2 June 2021DeSlOntology Term : 'hepatocyte' added !
118799view07:43, 2 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118798view07:43, 2 June 2021DeSlAdded description from WP313
118039view11:50, 23 May 2021EweitzModified title
109466view10:53, 18 March 2020L DupuisConverted interaction lines representing membrane to graphical lines
87669view08:55, 25 July 2016LindarieswijkOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
68877view17:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
41018view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
33939view18:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33484view15:08, 30 November 2009MaintBotRemoved group label
31534view21:45, 13 August 2009MaintBotFixed text labels
30379view21:02, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
DOCK1GeneProduct423960 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
FOSGeneProduct396512 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
HGFGeneProduct395941 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
ITGA1GeneProduct395951 (Entrez Gene)
ITGB1GeneProduct374058 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK8GeneProduct423778 (Entrez Gene)
MetGeneProduct396134 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PIK3CAGeneProduct424971 (Entrez Gene)
PTENGeneProduct423675 (Entrez Gene)
PTK2GeneProduct396416 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RAP1AGeneProduct419867 (Entrez Gene)
RAP1BGeneProduct417840 (Entrez Gene)
RAPGEF1GeneProduct417173 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SRCGeneProduct396442 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)

Annotated Interactions

No annotated interactions
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