p38 MAPK Signaling Pathway (Gallus gallus)

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1-8Stress: Osmotic shockg-radiation, AnisomycinFASL, InflammatoryCytokines, UV, etc.?Translation??DNA transcriptionGrowth Factors, UVTrophic Factors, etc.??Cytokines Production,Apoptosis, etc.TRAF2ChALK5MAP2K4MEF2DMAPKAPK5MAP2K6TRADDMYCApoptosisMAP3K9cRac1APLA2G4AELK1SHC1DAXXMAPK14HSPB1HMGN1MAPKAPK2MAPKAPK2ATF2MAPK14RIPK1DDIT3MKNK1TGFB2CDC42HRASGRB2STAT1RASGRF1MAXMAP3K5RPS6KA5MAP3K7MAP3K1CREB1Transcription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 91.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  2. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  3. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  4. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  6. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  7. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  8. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
111169view13:37, 21 July 2020EgonwMade another pathway clickable
95745view13:50, 19 January 2018MkutmonHomology conversion update
95123view15:07, 16 November 2017Mkutmonadded missing homology converter comment source
68866view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67571view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41005view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
38244view21:22, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38243view21:21, 27 August 2010Khanspers
35706view23:14, 12 February 2010KhanspersDescription and bibliography
33926view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33479view15:07, 30 November 2009MaintBotRemoved group label
31529view21:43, 13 August 2009MaintBotFixed text labels
30372view20:59, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProductENSGALG00000009287 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1386
ApoptosisPathwayWP254 (WikiPathways)
CDC42GeneProductENSGALG00000004796 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:998
CREB1GeneProductENSGALG00000041244 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1385
ChALK5GeneProductENSGALG00000033179 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7046
DAXXGeneProductNo homologues found for original id L:1616
DDIT3GeneProductNo homologues found for original id L:1649
ELK1GeneProductNo homologues found for original id L:2002
GRB2GeneProductENSGALG00000008016 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2885
HMGN1GeneProductENSGALG00000033985 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3150
HRASGeneProductENSGALG00000040551 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3265
HSPB1GeneProductENSGALG00000001926 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3315
MAP2K4GeneProductENSGALG00000032178 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
MAP2K6GeneProductENSGALG00000004370 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5608
MAP3K1GeneProductENSGALG00000014718 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
MAP3K5GeneProductENSGALG00000013892 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4217
MAP3K7GeneProductENSGALG00000015596 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6885
MAP3K9GeneProductENSGALG00000037326 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4293
MAPK14GeneProductENSGALG00000042833 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1432
MAPKAPK2GeneProductENSGALG00000000883 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9261
MAPKAPK5GeneProductENSGALG00000004743 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8550
MAXGeneProductENSGALG00000032249 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4149
MEF2DGeneProductENSGALG00000037787 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4209
MKNK1GeneProductENSGALG00000010440 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8569
MYCGeneProductENSGALG00000033631 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
PLA2G4AGeneProductENSGALG00000005065 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5321
RASGRF1GeneProductENSGALG00000008262 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5923
RIPK1GeneProductENSGALG00000012827 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8737
RPS6KA5GeneProductENSGALG00000030580 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9252
SHC1GeneProductENSGALG00000039775 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6464
STAT1GeneProductENSGALG00000007651 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6772
TGFB2GeneProductENSGALG00000009612 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7042
TRADDGeneProductENSGALG00000003195 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8717
TRAF2GeneProductENSGALG00000042838 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
cRac1AGeneProductENSGALG00000007130 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5879

Annotated Interactions

No annotated interactions
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