ACE Inhibitor Pathway (Gallus gallus)

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1Cell MembraneACEAldosteroneAGTR2KNG1BDKRB2ACE InhibitorAngiotensin IAGTR1ACEAngiotensin IIBradykininNOS3AGTREN


The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (


This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 77% conversion rate.

Quality Tags

Ontology Terms



  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC


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106121view12:02, 16 August 2019MaintBotHMDB identifier normalization
72067view17:33, 24 October 2013MaintBotUpdated data sources
68802view17:14, 8 July 2013MaintBotUpdated to 2013 gpml schema
67022view09:55, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57060view16:51, 20 January 2013EgonwUsed "PubChem-compound"
40935view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35046view09:35, 11 February 2010Thomasremoved genmapp notes (invalid link)
35038view09:28, 11 February 2010ThomasModified description
33478view15:06, 30 November 2009MaintBotRemoved group label
30370view20:58, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ACE InhibitorMetabolite
ACEGeneProduct419953 (Entrez Gene)
AGTGeneProduct421543 (Entrez Gene)
AGTR1GeneProduct396065 (Entrez Gene)
AGTR2GeneProduct428708 (Entrez Gene)
AldosteroneMetaboliteC01780 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
BDKRB2GeneProduct428906 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
KNG1GeneProduct424957 (Entrez Gene)

Annotated Interactions

No annotated interactions
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