IL-3 Signaling Pathway (Gallus gallus)

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CY->PMMAReceptorNUDMAGOECDSumoylationEndoplasmic reticulumInhibitionDMADMolecular AssociationEnzyme complexDDeacetylationMitochondrionMethylationAutophosphorylationDemethylationERDDGlycosylationProteins in a complex interactionTranslocationDGolgi apparatusReaction through unknown mechanisms/molecules(Protein-protein interaction)ControlUbiquitinationPhosphorylationAcetylationDCY->PMPlasma membraneCY->PMNucleusRecruitmentPalmitoylationEndosomeCYDCytoplasmDDDDDMT->CYLigandMolecule in the pathwayDeubiquitinationDProteolytic cleavageAccession Number: NetPath 15DephosphorylationMAMAENPMExtracellularCY->NUCY->NUDActivationDesumoylationDDMTMAGSK3BTECTNFRSF1BFESCRKLSHC1PRKACAYWHABSHC1RPS6KB2YWHAQIL3RASLC2A1MAPK3GAB2PIK3CATYK2PXNRXRAMAPK1PRKCBPILRBRCJMB04_11l21IL3BCL2L11KRASGATA2MAPK8BCL2L1STAT5BPIK3CDGATA1PTPN11SELPRAC2VAV1JAK2RCJMB04_19o18ID1PTPN6MAPK3BAXPIK3R1PPP2CAMATKIL3VCLNFKB1CSF2RBAKT1LCKBIRC5CHEK1KCNIP3GRB2PAK1CBLSTAT3FYNGene SymbolFCER2HSPB1RAPGEF1BMXRCJMB04_17i9BCL2MAP2K1ATF1IL3CISHSPI1MAPK7CREB1SRCLYNINPP5DGSK3AGNB2L1SLC2A1BADJAK1RARARAP1AMAPK9MAPKAPK2PTK2HRASRAF1CSF2RBSOCS2CRKATF2MMP9GAB1FOXO1ASTAT5AMAPK14RCJMB04_5a10CDC42SOS1BADSOCS3MRASDNM1RAC1MMP2PIK3R2HCKIL3RANFKB1STAT6RCJMB04_5a10IL3


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP286(r21281) with a 69% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
86927view13:03, 15 July 2016MkutmonOntology Term : 'interleukin-3 signaling pathway' added !
68833view17:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
40969view22:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
35791view06:54, 13 February 2010MaintBotAdded description
33894view17:57, 9 December 2009MaintBotAutomatic update of empty xrefs
31528view21:43, 13 August 2009MaintBotFixed text labels
30369view20:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
ATF1GeneProduct426873 (Entrez Gene)
ATF2GeneProduct395727 (Entrez Gene)
BADGeneProduct
BAXGeneProduct
BCL2GeneProduct396282 (Entrez Gene)
BCL2L11GeneProduct
BCL2L1GeneProduct373954 (Entrez Gene)
BIRC5GeneProduct374078 (Entrez Gene)
BMXGeneProduct428003 (Entrez Gene)
CBLGeneProduct374038 (Entrez Gene)
CDC42GeneProduct395917 (Entrez Gene)
CHEK1GeneProduct
CISHGeneProduct395335 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
CSF2RBGeneProduct771315 (Entrez Gene)
DNM1GeneProduct417217 (Entrez Gene)
FCER2GeneProduct
FESGeneProduct429374 (Entrez Gene)
FOXO1AGeneProduct374231 (Entrez Gene)
FYNGeneProduct396294 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GAB2GeneProduct419027 (Entrez Gene)
GATA1GeneProduct
GATA2GeneProduct416018 (Entrez Gene)
GNB2L1GeneProduct417044 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
GSK3AGeneProduct
GSK3BGeneProduct418335 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct419280 (Entrez Gene)
HRASGeneProduct396229 (Entrez Gene)
HSPB1GeneProduct396227 (Entrez Gene)
ID1GeneProduct395282 (Entrez Gene)
IL3GeneProduct474356 (Entrez Gene)
IL3RAGeneProduct
INPP5DGeneProduct424745 (Entrez Gene)
JAK1GeneProduct395681 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
KCNIP3GeneProduct
KRASGeneProduct418207 (Entrez Gene)
LCKGeneProduct
LYNGeneProduct421127 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK7GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MATKGeneProduct769076 (Entrez Gene)
MMP2GeneProduct386583 (Entrez Gene)
MMP9GeneProduct395387 (Entrez Gene)
MRASGeneProduct395149 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PIK3CAGeneProduct424971 (Entrez Gene)
PIK3CDGeneProduct419444 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PILRBGeneProduct
PPP2CAGeneProduct416318 (Entrez Gene)
PRKACAGeneProduct
PRKCBGeneProduct416567 (Entrez Gene)
PTK2GeneProduct396416 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PTPN6GeneProduct427947 (Entrez Gene)
PXNGeneProduct395832 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAC2GeneProduct418044 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RAP1AGeneProduct419867 (Entrez Gene)
RAPGEF1GeneProduct417173 (Entrez Gene)
RARAGeneProduct395213 (Entrez Gene)
RCJMB04_11l21GeneProduct425619 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_19o18GeneProduct427272 (Entrez Gene)
RCJMB04_5a10GeneProduct417430 (Entrez Gene)
RPS6KB2GeneProduct
RXRAGeneProduct417143 (Entrez Gene)
SELPGeneProduct424364 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SLC2A1GeneProduct396130 (Entrez Gene)
SOCS2GeneProduct395219 (Entrez Gene)
SOCS3GeneProduct395299 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
SPI1GeneProduct395879 (Entrez Gene)
SRCGeneProduct396442 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct395556 (Entrez Gene)
STAT6GeneProduct
TECGeneProduct396407 (Entrez Gene)
TNFRSF1BGeneProduct395083 (Entrez Gene)
TYK2GeneProduct395741 (Entrez Gene)
VAV1GeneProduct
VCLGeneProduct396422 (Entrez Gene)
YWHABGeneProduct419190 (Entrez Gene)
YWHAQGeneProduct421932 (Entrez Gene)

Annotated Interactions

No annotated interactions
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