Phase I biotransformations, non P450 (Gallus gallus)

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1OHOHHydrolysisOHOHPON2_CHICKQ5ZLQ2_CHICKCES1carboxylic acid esterscarboxylic acid estersPhosphoric acid estersCES7PON2_CHICKthio estersESDamidesPON2_CHICKCES2Phosphoric acid estersthio estersamides


This pathway lists several phase 1 biotransformations and their related enzymes. NOTE: This pathway is incomplete, reduction and oxidation enzymes are missing


This pathway was inferred from Homo sapiens pathway WP136(r29886) with a 62% conversion rate.

Quality Tags

Ontology Terms



  1. Klaassen, C.D., Watkins III, J.B.; ''Casarett & Doull's Essentials of Toxicology''; , 2003


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119628view08:17, 23 July 2021FinterlyRemoved nested Group.
119627view08:16, 23 July 2021FinterlyReverted to version '14:14, 21 July 2021' by Finterly
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119603view14:30, 21 July 2021Finterlyremoved amp;
119602view14:21, 21 July 2021Finterlyfixed '&'
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119600view14:14, 21 July 2021FinterlyReverted to version '14:18, 17 September 2019' by Finterly
119599view14:14, 21 July 2021FinterlyAdded ISBN for book citation
107109view14:18, 17 September 2019MaintBotChEBI identifier normalization
88308view15:28, 1 August 2016FehrhartOntology Term : 'cytochrome P450-independent phase I biotransformation pathway' added !
73510view23:18, 29 January 2014KhanspersModified title
68844view17:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
58777view22:16, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40982view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
33906view18:02, 9 December 2009MaintBotAutomatic update of empty xrefs
33469view15:04, 30 November 2009MaintBotRemoved group label
30360view20:55, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CES1GeneProduct415786 (Entrez Gene)
ESDGeneProductENSGALG00000016991 (Ensembl)
PON2_CHICKGeneProductENSGALG00000009689 (Ensembl)
Phosphoric acid estersMetabolite
Q5ZLQ2_CHICKGeneProductENSGALG00000006378 (Ensembl)
amidesMetaboliteCHEBI:32988 (ChEBI)
carboxylic acid estersMetabolite
thio estersMetabolite

Annotated Interactions

No annotated interactions
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