Hedgehog Signaling Pathway (Gallus gallus)

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1, 2CY->PMPalmitoylationCytoplasmProteins in a complex interactionGlycosylationCY->NUENSumoylationPM->ENUbiquitinationDCY->NUDemethylationNucleusDesumoylation(Protein-protein interaction)Molecular AssociationInhibitionGOMTNUDeubiquitinationDeacetylationDDEndosomeGene SymbolAccession Number: NetPath 10; cellmap:10ECReceptorCY->NUMethylationExtracellularGolgi apparatusCY->NUERPhosphorylationActivationMitochondrionEnzyme complexCYTranslocationControlMolecule in the pathwayRecruitmentDephosphorylationPlasma membraneReaction through unknown mechanisms/moleculesPM->ENAutophosphorylationCY->NUAcetylationEndoplasmic reticulumProteolytic cleavageLigandPMIGF2DYRK1ACDC2CDC2SMOPTCH1IHHGLI2HHIPIHHGAS1SHHGLI3GLI3CREBBPDHHGLI1SUFUSHHPTCH1SHHSIN3ASKIPTCH2SAP18RAB23SMOPTCH2SUFUSHHGLI1DHHHHIPPTCH2RAB23PTCH1PTCH1CCNB1CCNB1DHHGLI2IHHSUFUHHIPSTK36


Description

The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Comments

GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP47(r20775) with a 80% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Lum L, Beachy PA; ''The Hedgehog response network: sensors, switches, and routers.''; Science, 2004 PubMed
  2. Mohler J; ''Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.''; Genetics, 1988 PubMed

History

View all...
CompareRevisionActionTimeUserComment
68841view17:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
67331view10:38, 26 June 2013Christine ChichesterOntology Term : 'Hedgehog signaling pathway' added !
40979view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35742view23:52, 12 February 2010AlexanderPico
33903view18:01, 9 December 2009MaintBotAutomatic update of empty xrefs
31519view21:39, 13 August 2009MaintBotFixed text labels
30359view20:55, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNB1GeneProduct
CDC2GeneProduct396252 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
DHHGeneProduct
DYRK1AGeneProduct395233 (Entrez Gene)
GAS1GeneProduct
GLI1GeneProduct396045 (Entrez Gene)
GLI2GeneProduct395956 (Entrez Gene)
GLI3GeneProduct420769 (Entrez Gene)
HHIPGeneProduct422460 (Entrez Gene)
IGF2GeneProduct395097 (Entrez Gene)
IHHGeneProduct395801 (Entrez Gene)
PTCH1GeneProduct395806 (Entrez Gene)
PTCH2GeneProduct374187 (Entrez Gene)
RAB23GeneProduct421879 (Entrez Gene)
SAP18GeneProduct374206 (Entrez Gene)
SHHGeneProduct395615 (Entrez Gene)
SIN3AGeneProduct415307 (Entrez Gene)
SKIGeneProduct428181 (Entrez Gene)
SMOGeneProduct395949 (Entrez Gene)
STK36GeneProduct424210 (Entrez Gene)
SUFUGeneProduct374118 (Entrez Gene)

Annotated Interactions

No annotated interactions
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